Location: Home > Scientists
  Associate Professor
Name:
 HAN Zhiming
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807090  / 
E-mail:
 hanzm@ioz.ac.cn
Address:
 The State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences,1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
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Research Interests:

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Han Z, Liang CG, Cheng Y, Duan X, Zhong Z, Potireddy S, Moncada C, Merali S, Latham KE. 2010. Oocyte Spindle Proteomics Analysis Leading to Rescue of Chromosome Congression Defects in Cloned Embryos. J Proteome Res. 9(11):6025-6032.
  2. Han Z, Cheng Y, Liang CG, Latham KE. 2010. Nuclear transfer in mouse oocytes and embryos. Methods Enzymol. 476:171-184.
  3. Han Z, Mtango NR, Zhong Z, Vassena R, Latham KE. 2010. Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos. Am J Physiol Cell Physiol. 298(5):C1235-1244.
  4. Han Z, Mtango NR, Patel BG, Sapienza C, Latham KE. 2008. Hybrid Vigor and Transgenerational Epigenetic Effects on Early Mouse Embryo Phenotype. Biology of Reproduction. 79(4):638-648.
  5. Han Z, Vassena R, Chi MM, Potireddy S, Sutovsky M, Moley KH, Sutovsky P, Latham KE. 2008. Role of glucose in cloned mouse embryo development. Am J Physiol Endocrinol Metab. 295(4):E798-809.
  6. Liang CG, Han Z, Cheng Y, Zhong Z, Latham KE. 2009. Effects of ooplasm transfer on paternal genome function in mice. Hum Reprod. 24(11):2718-2728
  7. Wang J, Zhang M, Zhang Y, Kou Z, Han Z, Chen DY, Sun QY, Gao S. 2009. The Histone Demethylase JMJD2C Is Stage-Specifically Expressed in Preimplantation Mouse Embryos and Is Required for Embryonic Development. Biol Reprod. 82(1):105-111.
  8. Shi LH, Ai JS, Ouyang YC, Huang JC, Lei ZL, Wang Q, Yin S, Han ZM, Sun QY, Chen DY. 2008. Trichostatin A and nuclear reprogramming of cloned rabbit embryos. Journal of animal science 86(5):1106-1113.
  9. Shi LH, Miao YL, Ouyang YC, Huang JC, Lei ZL, Yang JW, Han ZM, Song XF, Sun QY, Chen DY. 2008. Trichostatin A (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos. Developmental Dynamics. 237(3):640-648.
  10. Han Z, Vandevoort CA, Latham KE. 2007. Therapeutic cloning: status and prospects. Current opinion in molecular therapeutics. 9(4):392-397.
  11. Vassena R, Han Z, Gao S, Latham KE. 2007. Deficiency in recapitulation of stage-specific embryonic gene transcription in two-cell stage cloned mouse embryos. Molecular Reproduction and Development. 74(12):1548-1556.
  12. Kuzmin A, Han Z, Golding MC, Mann MR, Latham KE, Varmuza S. 2008. The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues. Gene Express Patterns. 8(2):107-116.
  13. Hao L, Vassena R, Wu G, Han Z, Cheng Y, Latham KE, Sapienza C. 2009. The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome. Biol Reprod. 80(5):944-953.
  14. Cheng Y, Wang K, Kellam LD, Lee YS, Liang CG, Han Z, Mtango NR, Latham KE.  2009. Effects of Ooplasm Manipulation on DNA Methylation and Growth of Progeny in mice. Biology of Reproduction. 80(3):464-472.
  15. Vassena R, Han Z, Gao S, Baldwin DA, Schultz RM, Latham KE. 2007. Tough beginnings: alterations in the transcriptome of cloned embryos during the first two cell cycles. Developmental Biology. 304(1):75-89.
  16. Latham KE, Gao S, Han Z. 2007. Somatic cell nuclei in cloning: strangers traveling in a foreign land. Advances in experimental medicine and biology. 591:14-29.
  17. Miyara F, Han Z, Gao S, Vassena R, Latham KE. 2006. Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones. Developmental Biology. 289(1):206-217.
  18. Han Z, Chung YG, Gao S, Latham KE. 2005. Maternal factor controlling blastomere fragmentation in early mouse embryos. Biology of Reproduction. 72(3):612-618.
  19. Gao S, Wu G, Han Z, de la Casa E, Sapienza C, Latham KE. 2005. Recapitulation of the Ovum mutant (Om) phenotype and loss of Om locus polarity in cloned mouse embryos. Biology of Reproduction. 72(2):487-491.
  20. Nolan L, Gao S, Han Z, Chung YG, Bartolomei M, Latham KE. 2005. Aberrant X chromosome regulation in cloned mice. Developmental Biology. 279(2):525-540.
  21. Wu G, Hao L, Han Z, Gao S, Latham KE, Pardo-Manuel de Villena F, Sapienza C. 2005. Maternal transmission ratio distortion at the mouse Om locus results from meiotic drive at the second meiotic division. Genetics. 170: 327-334.
  22. Becker M, Becker A, Miyara F, Han Z, Kihara M, Brown DT, Hager GL, Latham K, Adashi EY, Misteli T. 2005. Differential in vivo binding dynamics of somatic and oocyte-specific linker histones in oocytes and during ES cell nuclear transfer. Molecular Biology of the Cell. 16(8): 3887-3895.
  23. Gao S, Han Z, Kihara M, Adashi E, Latham KE. 2005. Effects of protease inhibitor MG132 on nuclear reprogramming in cloned mouse embryos. Trends in Biotechnology. 23(2):66-68.
  24. Gao S, Czirr E, Chung YG, Han Z, Latham KE. 2004. Genetic variation in oocyte phenotype revealed through parthenogenesis and cloning: correlation with differences in pronuclear epigenetic modification. Biology of Reproduction. 70(4):1162-1170.
  25. Han ZM, Chen DY, Li JS, Sun QY, Wan QH, Kou ZH, Rao G, Lei L, Liu ZH, Fang SG. 2004. Mitochondrial DNA heteroplasmy in calves cloned by using adult somatic cell. Molecular Reproduction and Development. 67(2):207-214.
  26. Han ZM, Chen DY, Li JS, Sun QY, Wang PY, Du J, Zhang HM. 2003. Flow cytometric cell-cycle analysis of cultured fibroblasts from the giant panda, Ailuropoda melanoleuca L. Cell Biology International. 27(4):349-353.
  27. Yang CX, Han ZM, Wen DC, Sun QY, Zhang KY, Zhang LS, Wu YQ, Kou ZH, Chen DY. 2003. In vitro development and mitochondrial fate of macaca-rabbit cloned embryos. Molecular Reproduction and Development. 65(4):396-401.
  28. Zhu ZY, Chen DY, Li JS, Lian L, Lei L, Han ZM, Sun QY. 2003. Rotation of meiotic spindle is controlled by microfilaments in mouse oocytes. Biology of Reproduction. 68(3):943-946.
  29. Zhu ZY, Wen DC, Han ZM, Lei L, Liu ZH, Kou ZH, Xu Y, Wang MK, Chen DY. 2003. The dynamics and functions of cytoskeleton during meiotic resumption induced by parthenogenetic activation in mouse oocytes. Progress in Biochemistry andBiophysics. 30(5):819-823.
  30. Chen DY, Li JS, Han ZM, Lei L, Liu ZH, Kou ZH, Ma SY, Du QK, Sun QY. 2003. Somatic cell bovine cloning: Effect of donor cell and recipients. Chinese Science Bulletin. 48(6):549-554.