JIN Wanzhu

JIN Wanzhu

  • Subject： Wild Animal Nutrition and Reproduction
  • Tel/Fax: +86-10-64806302  / 
  • Email： jinw@ioz.ac.cn
  • Address： Key Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, 1Beichen West Road, Chaoyang District, Beijing 100101, P.R. China
  • More： Regulation of Energy Metabolism Group      

Resume

Prof. Wanzhu Jin, Group leader of Energy regulatory mechanism group; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.

1999-2003, Ph.D. United Graduate School of Veterinary Sciences, Gifu University, Japan
1990-1994, BSc. Department of Veterinary Medicine, Yanbian University,Jilin

Professional Experience:
2010-, Professor at Institute of Zoology, Chinese Academy of Sciences
2006-2010, Postdoc,Harvard Medical School
2003-2006, Postdoc Riken Institute, Japan

Research Interests

Our major interest focus on three interconnected areas: 1) the differentiation, activation, and transdifferentiation of brown adipose tissue (BAT), exploring its developmental origins, regulatory mechanisms, and thermogenic modulation in energy metabolism, alongside translational strategies to improve obesity and metabolic disorders; 2) the discovery and translational validation of key therapeutic targets for metabolic diseases, particularly those involved in abnormal glucose and lipid metabolism, building on prior insights into BAT and energy homeostasis; 3) the development of radionuclide-based targeted imaging and therapeutic strategies for cancer, leveraging tumor-specific surface markers (e.g., PSMA, FAP, GPC3) to design radiotracers, perform in vivo functional imaging, and evaluate targeted interventions for early diagnosis, treatment monitoring, and precision therapy, while bridging metabolic diseases with oncological applications to facilitate clinical translation of novel drugs and personalized medicine.

Selected Publications

(1) Jiang R#, Huang Y#, Ye R, Zhang Y, Dong M, Zhang H, Cheng Z, Zhang Z, Zhang J, Zhang Q*, Sun G*, Jin W*. Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis. Front Immunol.2025, 16:1543288

(2) Zhao Yiming#, Zhang hanlin#, Zhao Zhizhuang#, Liu Fangfang#, Dong Meng#, Chen Li#, Shen Mingzhi#, Luan Zhe#, Zhang Hanwen, Wu Junling, Li Congyong, Chen Jun, Li Chao, Liu Zhiwei, Chen Yi, Zheng Aihua, Li Huiling*, Wang Shufang*, Jin Wanzhu*, Sun Gang*. Efficacy and safety of Oral LL-37 against the Omicron BA.5.1.3 variant of SARS-COV-2: A randomized trial. J Med Virol, 2023 Aug;95(8):e29035.

(3) Hanlin Zhang#, Meng Dong#, Huihui Xu#, Hongyue Li, Aihua Zheng, Gang Sun*, Wanzhu Jin*. Recombinant Lactococcus lactis Expressing Human LL‑37 Prevents Deaths from Viral Infections in Piglets and Chicken. Probiotics Antimicrob Proteins. 2024 Dec.16(6):2150-2160.

(3) Hanlin Zhang#, Meng Dong#, Shouli Yuan#, Wanzhu Jin*. Oral glucagon-like peptide 1 analogue ameliorates glucose intolerance in db/db mice. Biotechnol Lett. 2022 Oct; 44(10):1149-1162.

(4) Zhou H#, Zhang H#, Ye R#, Yan C#, Lin J, Huang Y, Jiang X, Yuan S, Chen L, Jiang R, Zheng K, Cheng Z, Zhang Z, Dong M*, Jin W*. Pantothenate protects against obesity via brown adipose tissue activation. Am J Physiol Endocrinol Metab. 2022 May. 323(1):E69-E79.

(5) Ye Rongcai#, Yan Chunlong#, Zhou Huiqiao#, Zhang Chuanhai#, Huang Yuanyuan, Dong Meng, Zhang Hanlin, Lin Jun, Jiang Xiaoxiao, Yuan Shouli, Chen Li, Jiang Rui, Cheng Ziyu, Zheng Kexin, Zhang Qiaoli, Quan Linhu, Jin Wanzhu*. Brown adipose tissue activation by ginsenoside compound K treatment ameliorates polycystic ovary syndrome. Br J Pharmacol. 2022, Sep. 179(18):4563-4574.

(6) Yuan Shouli#, Dong Meng, Zhang Hanlin, Jiang Xiaoxiao, Yan Chunlong, Ye Rongcai, Zhou Huiqiao, Chen Li, Lian Huiru, Jin Wanzhu*, Ginsenoside PPD inhibit the activation of HSCs by directly targeting TGFβR1, Int J Biol Macromol, 2022, 194:556-562.

(7) Chun-Long Yan#, Jun Lin#, Yuan-Yuan Huang#, Qing-Shan Gao#, Zheng-Yu Piao#, Shou-Li Yuan, Li Chen, Xue Ren, Rong-Cai Ye, Meng Dong, Han-Lin Zhang, Hui-Qiao Zhou, Xiao-Xiao Jiang, Wan-Zhu Jin, Xu-Ming Zhou, Chang-Guo Yan. Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle. Zoological Research, 2022, 43(2): 275-284.

(8) Lin Jun#, Jiang Xiaoxiao#, Dong Meng, Liu Xiaomeng, Shen Qiwei, Huang Yuanyuan, Zhang Hanlin, Ye Rongcai, Zhou Huiqiao, Yan Chunlong, Yuan Shouli, Wu Xiangnan, Chen Li, Wang Yanfang, He Min, Tao Yi, Zhang Zhaoyun*, Jin Wanzhu*, Hepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue, Advanced Science, 2021, 8(21):e2101991.

(9) Ye Rongcai#, Yan Chunlong#, Zhou Huiqiao#, Huang Yuanyuan, Dong Meng, Zhang Hanlin, Jiang Xiaoxiao, Yuan Shouli, Chen Li, Jiang Rui, Cheng Ziyu, Zheng Kexin, Zhang Qiaoli*, Jin Wanzhu*, Brown Adipose Tissue Activation by Cold Treatment Ameliorates Polycystic Ovary Syndrome in Rat, Front Endocrinol, 2021 Oct 14;12:744628.

(10) Yuan Shouli#, Dong Meng#, Zhang Hanlin#, Xu Hongde#, Wang Qi#, Yan Chunlong, Ye Rongcai, Jiang Xiaoxiao, Zhou Huiqiao, Chen Li, Cheng Jun*, Xie Wen*, Jin Wanzhu*, Oral delivery of a Lactococcus lactis expressing extracellular TGFβR2 alleviates hepatic fibrosis. Appl Microbiol Biotechnol, 2021, 105(14-15):6007-6018.

(11) Huang YY#, Zhang HL, Dong M, Zhang L, Lin J, Ye RC, Zhou HQ, Liu XM*, Jin W*. miR17-92 cluster drives white adipose tissue browning. J Mol Endocrinol. 2020, 65(3):97-107.

(12) Linhu Quan#, Chuanhai Zhang#, Meng Dong#, Jun Jiang#, Hongde Xu#, chunlong Yan#, Xiaomeng liu, Huiqiao Zhou, Hanlin Zhang, Li Chen,Fei liang Zhong, Zhaobo luo, Sin Man lam, Guanghou Shui, Donghao li*, Wanzhu Jin*. Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut. 2020; 69(7):1239-1247.