SUN Qinmiao

SUN Qinmiao

  • Subject： Cell Biology
  • Tel/Fax: +86-10-64807391  / 
  • Email： qinmiaosun@ioz.ac.cn
  • Address： Institute of Zoology, Chinese Academy of Sciences (CAS). Institute for Stem Cell and Regenerative Medicine, CAS, Yard A 3, Datun Road, Chaoyang District, Beijing 100101, P. R. China
  • More： Group of Immunity and Signal Transduction      

Resume

Infectious diseases are major health threats throughout the world. The main function of our immune system is to fight viral and bacteria invasions. Innate immunity is the first line for defense against microbial infections. In my lab, we are interested in understanding the molecular mechanisms of antiviral innate immunity by using different model systems such as mouse and fly. Meanwhile, we are also interested in the regulatory mechanisms underlying the fate determination of stem cells.

Research Interests

Antiviral innate immunity; Stem cell biology.

Selected Publications

  1. Zhang, G., Miao, Y., Song, Y., Wang, L., Li, Y., Zhu, Y., Zhang, W., Sun, Q.*, and Chen, D.* (2024) HIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA in Drosophila embryos. Proc Natl Acad Sci U S A 121, e2410261121
  2. Li, Y., Zhao, D., Chen, D., and Sun, Q.* (2024) Targeting protein condensation in cGAS-STING signaling pathway. Bioessays 46, e2400091
  3. Lin, Y., Yang, J., Yang, Q., Zeng, S., Zhang, J., Zhu, Y., Tong, Y., Li, L., Tan, W., Chen, D.*, and Sun, Q.* (2023) PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling. Nat Commun 14, 7567
  4. Tao, X., Song, J., Song, Y., Zhang, Y., Yang, J., Zhang, P., Zhang, D., Chen, D.*, and Sun, Q.* (2022) Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase. Cell Rep 40, 111310
  5. Gao, Y., Zhu, Y., Sun, Q.*, and Chen, D.* (2023) Argonaute-dependent ribosome-associated protein quality control. Trends Cell Biol 33, 260-272
  6. Sun, J., Yang, Q., Liu, E., Chen, D.*, and Sun, Q.* (2022) KIZ/GM114 Balances the NF-kB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adaptors. Front Cell Dev Biol 10, 877039
  7. Gu, H., Yang, J., Zhang, J., Song, Y., Zhang, Y., Xu, P., Zhu, Y., Wang, L., Zhang, P., Li, L., Chen, D.*, and Sun, Q.* (2022) PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation. Nat Commun 13, 1564
  8. Gao, Y., Zhu, Y., Wang, H., Cheng, Y., Zhao, D., Sun, Q.*, and Chen, D.* (2022) Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination. Mol Cell 82, 1313-1328 e1318（封面文章）
  9. Zhang, G., Xu, Y., Wang, X., Zhu, Y., Wang, L., Zhang, W., Wang, Y., Gao, Y., Wu, X., Cheng, Y., Sun, Q.*, and Chen, D.* (2022) Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay. Nat Commun 13, 859
  10. Tao, X., Chu, B., Xin, D., Li, L., and Sun, Q.* (2020) USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I. PLoS Pathog 16, e1008293
  11. He, S., Zhang, G., Wang, J., Gao, Y., Sun, R., Cao, Z., Chen, Z., Zheng, X., Yuan, J., Luo, Y., Wang, X., Zhang, W., Zhang, P., Zhao, Y., He, C., Tao, Y.*, Sun, Q.*, and Chen, D.* (2019) 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda. Nat Commun 10, 2219
  12. Ji, S., Luo, Y., Cai, Q., Cao, Z., Zhao, Y., Mei, J., Li, C., Xia, P., Xie, Z., Xia, Z., Zhang, J., Sun, Q.*, and Chen, D.* (2019) LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan. Mol Cell 74, 363-377 e365
  13. Ji, S., Li, C., Hu, L., Liu, K., Mei, J., Luo, Y., Tao, Y., Xia, Z., Sun, Q.*, and Chen, D.* (2017) Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A. Proc Natl Acad Sci U S A 114, 6316-6321
  14. Lin, W., Zhang, J., Lin, H., Li, Z., Sun, X., Xin, D., Yang, M., Sun, L., Li, L., Wang, H., Chen, D., and Sun, Q.* (2016) Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nat Commun 7, 11848
  15. Sun, X., Sun, L., Zhao, Y., Li, Y., Lin, W., Chen, D., and Sun, Q.* (2016) MAVS maintains mitochondrial homeostasis via autophagy. Cell Discov 2, 16024
  16. Li, Z., Liu, G., Sun, L., Teng, Y., Guo, X., Jia, J., Sha, J., Yang, X., Chen, D., and Sun, Q.* (2015) PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation. PLoS Pathog 11, e1004783
  17. Ji, S., Sun, M., Zheng, X., Li, L., Sun, L., Chen, D.*, and Sun, Q.* (2014) Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila. Nat Commun 5, 3458
  18. Zhao, Y., Sun, X., Nie, X., Sun, L., Tang, T. S., Chen, D., and Sun, Q.* (2012) COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production. PLoS Pathog 8, e1003086
  19. Sun, Q., Sun, L., Liu, H. H., Chen, X., Seth, R. B., Forman, J., and Chen, Z. J.* (2006) The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24, 633-642
  20. Sun, Q., Matta, H., and Chaudhary, P. M.* (2003) The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation. Blood 101, 1956-1961