Education:

2002.1-2005.1             Ph.D. Molecular Biology, The Hong Kong Polytechnic University, Hong Kong, P. R. China

1993.9-1996.8             M.Phil. Biochemistry, The Hong Kong University of Science and Technology, Hong Kong, P. R. China

1984.9-1988.7            B.S. Biochemistry, Peking University, Beijing, P. R. China

Employment:

2011.1-Now        Associate Professor, Institute of Zoology, Chinese Academy of Sciences

2009.2-2011.1            Visiting Scientist, UT MD Anderson Cancer Center

2001.2-2001.8            Visiting Scholar, The Hong Kong University of Science and Technology

1996.9-2009.1            Assistant Professor, Institute of Zoology, Chinese Academy of Sciences

1988.7-1993.8            Research assistant, Institute of Zoology, Chinese Academy of Sciences

Investigate the regulatory mechanism of microRNA methylation on disease-related genes.

1. Cheng, Y.#, Wang, Z. M.#, Tan, W. #, Wang, X.#, Li, Y., Bai, B., Li, Y., Zhang, S. F., Yan, H. L., Chen, Z. L., Liu, C. M., Mi, T. W., Xia, S., Zhou, Z., Liu, A., Tang, G. B., Liu, C., Dai, Z. J., Wang, Y. Y., Wang, H., Wang, X., Kang, Y., Lin, L., Chen, Z., Xie, N., Sun, Q., Xie, W., Peng, J., Chen, D., Teng, Z. Q., and Jin, P. (2018) Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nat Neurosci 21, 1689-1703 (#, cofirst auther)
2. Jin, W., Wang, L., Zhu, F., Tan, W., Lin, W., Chen, D., Sun, Q., and Xia, Z. (2016) Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming. Sci Rep 6, 20818
3. Tan, W., Gu, J., Huang, M., Wu, X., and Hildebrandt, M. A. (2015) Epigenetic analysis of microRNA genes in tumors from surgically resected lung cancer patients and association with survival. Mol carcinog 54 Suppl 1, E45-51
4. Zhu, G., Li, Y., Zhu, F., Wang, T., Jin, W., Mu, W., Lin, W., Tan, W., Li, W., Street, R. C., Peng, S., Zhang, J., Feng, Y., Warren, S. T., Sun, Q., Jin, P., and Chen, D. (2014) Coordination of engineered factors with TET1/2 promotes early-stage epigenetic modification during somatic cell reprogramming. Stem cell reports 2, 253-261
5. Hildebrandt, M. A., Tan, W., Tamboli, P., Huang, M., Ye, Y., Lin, J., Lee, J. S., Wood, C. G., and Wu, X. (2012) Kinome expression profiling identifies IKBKE as a predictor of overall survival in clear cell renal cell carcinoma patients. Carcinogenesis 33, 799-803 
6. Tan, W., Hildebrandt, M. A., Pu, X., Huang, M., Lin, J., Matin, S. F., Tamboli, P., Wood, C. G., and Wu, X. (2011) Role of inflammatory related gene expression in clear cell renal cell carcinoma development and clinical outcomes. J Urol 186, 2071-2077
7. Hildebrandt, M. A., Gu, J., Lin, J., Ye, Y., Tan, W., Tamboli, P., Wood, C. G., and Wu, X. (2010) Hsa-miR-9 methylation status is associated with cancer development and metastatic recurrence in patients with clear cell renal cell carcinoma. Oncogene 29, 5724-5728
8. Tan, W., Wang, J. X., Lin, Z. Q., Li, Y. R., Lin, Y., and Li, P. F. (2008) Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin. Circulation 118, 2268-2276
9. Tan, W., Wang, K., Lv, D.Y., and Li, P.F. (2008) Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. J Biol Chem 283, 29730-29739
10. Tan, W., Gou, D. M., Tai, E., Zhao, Y. Z., and Chow, L. M. (2006) Functional reconstitution of purified chloroquine resistance membrane transporter expressed in yeast. Arch Biochem Biophys 452, 119-128