Du Lei

Du Lei

  • Subject: Molecular biology
  • Tel/Fax: +86-10-64807322  /  +86-10-64807322
  • Email: dul@ioz.ac.cn
  • Address: The State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences,Beichen West Road 1#-5, Chaoyang District, Beijing, China
  • More: Group of Molecular and Cellular Neuroscience      

Resume

2014-present Associate Professor, The State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences.

2007-2014 Assistant Professor, The State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences.

2002- 2007 Ph.D. Cellular Biology, Institute of Zoology, Chinese Academy of Sciences.

1998- 2002 Bachelor degree of Life Science. Wuhan University, Hubei, China.

Research Interests

cancer stem cell

Research Grants

National Key Research and Development Project (2016-2021). Sub-project Leader

National Natural Science Foundation of China (2014-2017): Molecular mechanism of cellular prion protein induced cancer metastasis. Project Leader

National Natural Science Foundation of China (2010-2013): Mechanism of PTO induced cancer stem cell death. Project Leader;

Selected Publications

  1. Du L, Rao G, Wang H, Li B, Tian W, Cui JT, He L, Laffin B, Tian X, Hao C, Liu H, Sun X, Zhu Y, Tang DG, Mehrpour M, Lu Y*, Chen Q*. CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic     capacity in colorectal cancer, Cancer Research, 73(8): 2682-2694, 2013.
  2. Rao GH#, Liu HM#, Li BW, Hao JJ, Yang YL, Wang MR, Wang XH, Wang J, Jin HJ, Du L*, Chen Q *. Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic     drugs. Acta Pharmacologica Sinica ,34(6): 793–804, 2013.(Co-corresponding author)
  3. Rao G, Wang H, Li B, Huang L, Xue D, Wang X, Jin H, Wang J, Zhu Y, Lu Y, Du L*, Chen Q*. Reciprocal interactions between tumor-associated macrophages and CD44-Positive cancer cells via Osteopontin/CD44 promote tumorigenicity     in colorectal cancer. Clin Cancer Res. 19(4):785-97, 2013. (Co-corresponding author)
  4. Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y*, Chen Q*. CD44 is of functional importance for colorectal cancer stem cell. Clinical Cancer research, 14(21), 6751-6760, 2008.
  5. Liu D, Du L, Chen D, Ye Z, Duan H, Tu T, Feng J, Yang Y, Chen Q, Yan X*. Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signalling. Oncotarge, 7(26):40704-40718,     2016.