LI Jingyi

LI Jingyi

  • Subject： Functional genomics of aging
  • Tel/Fax: +86-10-64807583  / 
  • Email： lijingyi@ioz.ac.cn
  • Address： State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, 3A Datun Road, Chaoyang District, Beijing 100101, China
  • More： Group of Aging and Regeneration      

Resume

Biography

2008 - 2012 B.S., Hebei Agricultural University

2012 - 2017 Ph.D., Peking University

2017 - 2019 Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

2019 – Now Associate Professor, Institute of Zoology, Chinese Academy of Sciences

Research Interests

Utilizing an integrative multi-omics strategy, we aim to elucidate the intricate mechanisms of aging and the etiology of age-related diseases at multiple biological levels, thereby identifying novel therapeutic targets for the enhancement of geriatric interventions.

Selected Publications

(#: co-first author)

  1. Li J#, Lu X#, Tong T#, Zhou X#, Zhang B#, Sun X#, Zhao B#, Xu G#, Yang J, Fan Y, Hu J, Yan H, Ji Z, Li M, Che S, Yang Y, Ding Y, Wang Q, Sun S, Ma S, Wang S, Izpisua Belmonte JC, Qu J, Zhang W, Liu GH. Single-nucleus interrogation of primate small intestinal aging reveals NCoR1 decline as a conserved feature that is reversed by metformin. Nature Aging. 2026. 6(6):1298-1318.
  2. Li J#, Zheng Y#, Yan P#, Song M#, Wang S#, Sun L, Liu Z, Ma S, Chan P, Zhou Q, Belmonte JC, Zhang W, Liu GH, Tang F, Qu J. A single-cell transcriptomic atlas of primate pancreatic islet aging. National Science Review. 2021. 8(2):nwaa127.
  3. Wang S#, Zheng Y#, Li J#, Yu Y#, Zhang W#, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC, Jing Qu, Tang F, Liu GH. Single-cell transcriptomic atlas of primate ovarian aging. Cell. 2020. 180(3): 585-600. (Cover story)
  4. Li J#, Zhou X#, Liu X#, Ren J#, Wang J, Wang W, Zheng Y, Shi X, Sun T, Li Z, Kang A, Tang F, Wen L, Fu W. Detection of colorectal cancer in circulating cell-free DNA by methylated CpG tandem amplification and sequencing. Clinical Chemistry. 2019. 65(7):916-926.
  5. Yang J#, Li J#, Suzuki K#, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Belmonte JC, Qu J, Tang F, Liu GH. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Research. 2017. 27(9):1178-1181.
  6. Zhang W#, Li J#, Suzuki K#, Qu J#, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015. 348(6239):1160-1163.

Reviews：

  1. Biomarkers of aging. Science China Life Science. 2023. 66(5):893-1066. (Cover story)
  2. The landscape of aging. Science China Life Science. 2022. 65(12): 2354–2454.