LIU Guanghui

LIU Guanghui

  • Subject： Regenerative Medicine
  • Tel/Fax: +86-10-64807852  / 
  • Email： ghliu@ioz.ac.cn
  • Address： 3A Datun Road, Chaoyang District, Beijing 100101, China
  • More： Group of Aging and Regeneration      

Resume

Biography

1997 - 2002 B.S., Peking University Health Science Center

2002 - 2007 Ph.D., Institute of Biophysics, Chinese Academy of Sciences

2007 - 2009 Research associate, Dept. of Cell and Molecular Biology, The Scripps Research Institute

2009 - 2012 Research associate, Gene expression laboratory, The Salk Institute for Biological Studies

2012 - 2019 Professor, Institute of Biophysics, Chinese Academy of Sciences

2019 - Professor, Institute of Zoology, Chinese Academy of Sciences

Research Interests

1. Decoding the genetic and epigenetic mechanisms of human aging

Combining primate models, stem cells, gene-editing techniques, genome-wide screening, single-cell sequencing, multi-omics analyses and artificial intelligence, we aim to study the genetic and epigenetic basis of human aging and aging-related diseases and explore new strategies for delaying aging (e.g. brain aging and cardiovascular aging) and for the prevention and treatment of aging-related diseases (e.g. neurodegenerative diseases and atherosclerosis) so as to achieve the goal of healthy aging.

2. Stem cell-based disease mechanism research and precision medicine on human diseases

Using patient-derived induced pluripotent stem cells (iPSC) and diseased embryonic stem cells (ESC) created in vitro, combined with directed differentiation and transplantation technologies, we aim to study molecular mechanisms and new targets of human diseases at the genome level, develop stem cell-based drug screening and evaluation systems, evaluate lead compounds that target specific targets of human diseases, and advance clinical translation of stem cell and aging-related technologies.

3. Development and application of new gene-editing methods and gene therapy technologies

On the basis of HDAdV, telHDAdV, TTALE and CRISPR/Cas9 techniques, we aim to develop new methods to safely and efficiently edit the human genome and establish new de-senescence and pro-regenerative strategies via the applications of stem cells and new strategies for gene therapy, thus providing scientific basis for gene repair in rare diseases, genetic enhancement of human stem cells, and intervention of aging-related diseases.

Awards and Honors

2025, Top 10 Science Advances in China

2025, Top 10 Scientific Advances in Life Sciences of China

2025, Most Cited Chinese Researchers (ELSEVIER)

2024, Chief scientist of Basic Science Center Program of NSFC

2024, Prize for Scientific and Technological Innovation of the Ho Leung Ho Lee Foundation

2024, Top 10 Scientific Advances in Life Sciences of China

2024, Outstanding Contribution Scientist in Stem Cell Research

2024, Most Cited Chinese Researchers (ELSEVIER)

Editorial board

Editor-in-Chief, Life Medicine (Impact factor 6.0)

Deputy Editor-in-Chief, Protein & Cell (Impact factor 12.8)

Advisory board, Cell Stem Cell (Impact factor 20.4)

Editorial board, PLOS Biology (Impact factor 7.2)

Editorial board, Aging Cell (Impact factor7.1)

Editorial board, Cell Reports (Impact factor 6.9)

Scientific committee/board

Founder & Council Member of Academy for Health & Lifespan Research (AHLR)

Vice Chairman of China Anti-Aging Promotion Association

President of Chinese Society for Aging Cell Research (CSACR)

Selected Publications

  1. Li J, Jiang B, Zhang W, Hao J, Liu Z, Ji Q, Zheng Y, Lu X, Zheng Z, Ma S, Fan Y, Gao DD, Hou XW, Li J, Tang J, Jing Y, Geng L, Wu R, Zhang B, Sun S, Cai Y, Yan K, Xiong M, Ma X, Dong C, Xu G, Ji Z, Yan H, Zheng Q, Huang H, Zhang L, Li J, Jiang M, Xu LJ, Chen Y, Qu G, Lei W, Wang H, Ping J, Zhou J, Yi M, Jiang M, Jing Y, Ye WD, Zhang X, Chu X, He Y, Zhao Q, Wu Q, He M, Ma L, Liu P, Zhao L, Zhai QC, Qin J, Lu J, Yang X, Zhang S, Xiong Y, Ren H, Yang W, Huang Z, Zhang J, Zhang M, Chen P, Jian D, Zhang Y, Yan T, Ye JL, Huang P, Qi Z, Liu Y, Shuai J, Chen CS, Li P, Li D, Xu X, Song X, Li J, Ping J, Hu J, Sun X, Ai J, Wang Z, Zhang Y, Yang P, Ning T, Yu Y, He Z, Zhang H, Zhang T, Yang Y, Wang Q, Lin F, Jin X, Chen X, Ren J, Song M, Wang S, Yang J, Li J, Song W, He F, Yang YG, Pei G, Qu J, Zhang W, Pu J, Zhang F, Zhao G, Zhang W, Liu GH. Multimodal Clocks of Human Aging. Cell. 2026. doi: 10.1016/j.cell.2026.04.025.
  2. Liu L, Zheng Z, You W, Yang P, Wen Y, Qiao Y, Ma S, Zhang H, Zhang S, Xu G, Ma C, Tian A, Jiang M, Zhang T, Geng L, Li J, Sun X, Wang F, Xiong M, Yang Y, Lu X, Jiang X, Dong X, Zhang Z, Huang Y, Zhang B, Qiao Q, Sun S, Fan Y, Cai Y, Yan K, Zhang Y, Jing Y, Jing Y, Wang Q, Lei J, Tan A, Han Z, Reddy P, Haghani A, Rodriguez Esteban C, Zhang F, Liu Z, Liu N, Wang S, Horvath S, Yang J, Izpisua Belmonte JC, Zhang W, Qu J, Liu GH. Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates. Cell Metabolism. 2026. 38(4):673-693.
  3. Sun X, Che S, Wang H, Fan Y, Ding Y, Tan A, Yang K, Hu J, Zhang Y, Ma M, Hu J, Sun S, Li J, Ma S, Wang S, Izpisua Belmonte JC, Qu J, Zhang W, Liu GH. Vascular organoid model of Hutchinson Gilford Progeria Syndrome uncovers repression of the SRF pathway in premature aging. Developmental Cell. 2026. 61(3):505-517.
  4. Sun G, He Z, Lv D, Wang Q, Xu G, Liu F, Wang P, Luo B, Zheng Y, Hu J, Sun S, Ma S, Rodriguez Esteban C, Yang J, Fu X, Belmonte JCI, Zhang W, Qu J, Wang S, Liu GH. Reprogramming the GRHL2-CDK19 axis by gene therapy alleviates prostate aging. Nature Aging. 2026. 6(1):252-269.
  5. Lei J, Xin Z, Liu N, Ning T, Jing Y, QiaoY, He Z, Jiang M, Yang Y, Zhang Z, Zhao L, Li J, Lv D, Yan Y, Zhang H, Xiao L, Zhang B, Huang H, Sun S, Zheng F, Jiang X, Lu H, Dong X, Yue S, Ma C, Shuai J, Ji Z, Liu F, Ye Y, Yan K, Hu Q, Xu G, Zhao Q, Wu R, Cai Y, Fan Y, Jing Y, Wang Q, Reddy P, Lu X, Zheng Z, Liu B, Haghani A, Ma S, Suzuki K, Rodriguez Esteban C, Yang J, Song M, Horvath S, Zhang W, Li W, Xiang AP, Zhu L, Fu X, Zhao G, Izpisua Belmonte JC, Qu J, Wang S, Liu GH. Senescence-resistant human mesenchymal progenitor cells counter aging in primates. Cell. 2025.188(18):5039-5061.
  6. Geng L, Ping J, Wu R, Yan H, Zhang H, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J, Wen Y, Jing Y, Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, Diao Z, Li M, Zhang H, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, Wang W, Ji Y, Gou B, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q, Cao T, Yang S, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y, Li Y, Li J, Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S, Song M, Zhang W, Qu J, Liu GH. Systematic profiling reveals betaine as an exercise mimetic for geroprotection. Cell. 2025. 188(19):5426-5428.
  7. Ding Y, Zuo Y, Zhang B, Fan Y, Xu G, Cheng Z, Ma S, Fang S, Tian A, Gao D, Xu X, Wang Q, Jing Y, Jiang M, Xiong M, Li J, Han Z, Sun S, Wang S, He F, Yang J, Qu J, Zhang W, Liu GH. Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures. Cell. 2025. 188(20): 5763-5784.
  8. Jing Y, Lu H, Li J, He Z, Zhao L, Zhang C, Huang Z, Liu L, Sun S, Ma S, Rodriguez Esteban C, Fu X, Zhao G, Izpisua Belmonte JC, Zhang W, Qu J, Wang S, Liu GH. Vitamin C conveys geroprotection on primate ovaries. Cell Stem Cell. 2025. 32(11). 1723-1740.
  9. Zhao Q, Jing Y, Jiang X, Zhang X, Liu F, Huang H, Zhang Z, Wang H, Sun S, Ma S, Zhang W, Yu Y, Fu X, Zhao G, Qu J, Wang S, Liu GH. SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1. Nature Metabolism. 2025. 7(3):556-573.
  10. Sun G, Fu X, Zheng Y, Hong G, Liu Z, Luo B, Lei J, Lv D, Chang M, Xiao Y, Guo S, Ma S, Lu L, Zhang W, Belmonte JCI, Qu J, Wang S, Chai R, Liu GH. Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging. Nature Aging. 2025. 5(9):1862-1879.
  11. Sun G, Li K, Ping J, Zhao L, Cui C, Wu J, Xie L, Yao X, Xu G, Ma S, Fan Y, Wang Q, Yang D, Luo B, Liu H, Yang J, Zhang W, Song W, Zhao G, Fu X, Bian XW, Qu J, Wang S, Chen H, Liu GH. A single-cell transcriptomic atlas reveals senescence and inflammation in the post-tuberculosis human lung. Nature Microbiology. 2025. 10(8):2073-2091.
  12. Yang Y, Lu X, Liu N, Ma S, Zhang H, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M, Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, Li J, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhu G, Song W, Horvath S, Esteban CR, Song M, Wang S, Zhao G, Li W, Izpisua Belmonte JC, Qu J, Zhang W, Liu GH. Metformin Decelerates Aging Clock in Male Monkeys. Cell. 2024. 187(22):6358-6378.
  13. Li HY, Wang M, Jiang X, Jing Y, Wu Z, He Y, Yan K, Sun S, Ma S, Wang S, Belmonte JCB, Qu J, Zhang W, Wei T, Liu GH. CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver. Nucleic Acids Research. 2024. 52(19):11481-11499.
  14. Ma S, Ji Z, Zhang B, Geng L, Cai Y, Nie C, Li J, Zuo Y, Sun Y, Xu G, Liu B, Ai J, Liu F, Zhao L, Zhang J, Zhang H, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X, Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Esteban CR, Liu Z, Deng H, Wen F, Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Belmonte JCI, Qu J, Zhang W, Gu Y, Liu GH. Spatial Transcriptomic Landscape Unveils Immunoglobin-associated Senescence as a Hallmark of Aging. Cell. 2024. 187(24):7025-7044.

Reviews or Views

  1. Multimorbidity defines glycaemic individuality in ageing. Nature Metabolism. 2026. doi: 10.1038/s42255-026-01518-8.
  2. Past, present and future perspectives on the science of aging. Nature Aging. 2026. 6(1):6-22.
  3. Biomarkers of ageing of humans and non-human primates. Nature Reviews Molecular Cell Biology. 2025. 26(11):826-847.
  4. The X-Age Project to construct a Chinese aging clock. Nature Aging. 2025. 5(9):1669-1685.
  5. Aging and immunity. Immunity. 2025. 58(11). 2609-2612.
  6. Exploring the heterogeneous targets of metabolic aging at single-cell resolution. Trends in Endocrinology & Metabolism. 2025. 36(2):133-146.
  7. Insights and Interventions in Age-Associated Inflammation. Current Opinion in Genetics and Development. 2025. 91:102306.
  8. Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases. Nature Reviews Molecular Cell Biology. 2024. 25(12):979-1000.
  9. Stress, epigenetics, and aging: unraveling the intricate crosstalk. Molecular Cell. 2024. 84(1):34-54.
  10. Perspectives on biomarkers of reproductive aging for fertility and beyond. Nature Aging. 2024. 4(12):1697-1710.
  11. Targeting aging and age-related diseases with vaccines. Nature Aging. 2024. 4(4):464-482.
  12. Emerging epigenetic insights into aging mechanisms and interventions. Trends in Pharmacological Sciences. 2024. 45(2):157-172.
  13. Metabolic heterogeneity in humans. Cell. 2024. 187(15):3821-3823.