YU Xin

YU Xin

  • Tel/Fax: +86-10-64807083  / 
  • Email： davidyx95@163.com
  • Address： Beijing Institute of Stem Cell and Regenerative Medicine, Datun Road Jia 3, Chaoyang District, Beijing, 100101, P.R. China
  • More： Group of Reproductive Pathology      

Resume

Xin Yu, Ph.D., associate professor, member of the Reproductive Pathology Group, Institute of Zoology, Chinese Academy of Sciences. He has been awarded a fellowship from the China Postdoctoral Science Foundation and serves as a principal contributor to multiple national grants, including the Joint Funds of the National Natural Science Foundation of China (NSFC) with Enterprises and the NSFC Major Programs. Dr. Yu completed his undergraduate studies at Northwest A&F University in 2017 and later earned his Doctor of Medicine (M.D.) degree from the Institute of Zoology, Chinese Academy of Sciences, in 2023 under the guidance of Professor Yan-Ling Wang. He was promoted to associate professor in 2026.

Dr. Yu's primary research interests lie in maternal–fetal nutrient transport and metabolic regulation, immune regulation at the maternal–fetal interface, and the construction of model systems that recapitulate key functional units of the maternal–fetal interface. Centered on core scientific questions—such as syncytiotrophoblast (STB) differentiation and the establishment of endocrine/barrier functions, the formation of immune tolerance at the maternal–fetal interface, and the remodeling of maternal supply pathways—he systematically dissects the molecular mechanisms along the "metabolic rewiring–epigenetic regulation–cell fate determination/functional execution" axis. He further investigates placenta-derived pathogenic mechanisms and potential intervention targets in pregnancy-related disorders, including preeclampsia, fetal growth restriction, early pregnancy loss, and recurrent pregnancy failure. Dr. Yu has published 10 peer-reviewed papers as first author or co–first author in international journals including Cell Stem Cell, Nature Reviews Endocrinology, National Science Review, and Cell Communication and Signaling, and has co-authored an additional 9 publications. He currently serves as a reviewer for Cell Proliferation, Placenta, and Seminars in Immunopathology.

Research Grants

Joint Funds of the National Natural Science Foundation of China with Enterprises (U25C2007):Mechanisms and intervention strategies for pathological uterine scar–associated placenta accreta spectrum disorders based on immune–fibroblast crosstalk regulation(2026.01–present), key participant, Amount: RMB 2, 100, 000

A fellowship from the China Postdoctoral Science Foundation (Certificate Number: 2024M763250):Mechanisms of Histone Acetylation Governing Trophoblast Syncytialization Fate in Human Placenta (P.I. 2024.12-2026.01), RMB 80, 000

Selected Publications

  1. Xin Yu#, Qianqian Li#; Xuan Shao*; Amanda N Sferruzzi-Perri*, Yan-Ling Wang*. Fine-tuned programming of placenta trophoblast determines optimal maternal–fetal nutrient allocation[J], Current Opinion in Genetics & Development, 2025, 91:102305.
  2. Xin Yu#, Hao Wu#, Jiali Su#, Xupeng Liu, Kun Liang, Qianqian Li, Ruoxuan Yu, Xuan Shao, Hongmei Wang*, Yan-Ling Wang*, Ng Shyh-Chang*. Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells[J]. Cell Stem Cell, 2024, S1934-5909(24)00253-4.
  3. Xin Yu#, Hongyu Wu#, Yun Yang, Feiyang Wang, Yan-Ling Wang*, Xuan Shao*. Placental development and pregnancy-associated diseases[J]. Maternal-Fetal Medicine, 2022, 4(1): 36-51.
  4. Yuanfeng Gao#, Xin Yu#, Yuefan Wang#, Hongmei Wang*, Yan-Ling Wang*, Ng Shyh-Chang*. Metabolic control of feto–placental development and pregnancy outcomes[J], Nature Reviews Endocrinology, 2025
  5. Yuelin Zhu#, Qianqian Li#, Xin Yu#, Yun Yang, Qian Yang, Yongqing Wang*, Xuan Shao*, Yan-Ling Wang*. Lactate shuttle between cytotrophoblast and syncytiotrophoblast in the placenta enhances ferroptosis resistance and maintains placental homeostasis: implications for early pregnancy loss[J], Cell Communication and Signaling, 2025, 23, 438
  6. Shenglong Ye#, Xin Yu#, Wentong Jia, Wenlong Li, Yan-Ling Wang*, Yongqing Wang*, Hydroxychloroquine improves pregnancy outcomes by inhibiting excessive autophagy in extravillous trophoblast caused by an anti-phospholipid syndrome[J], International Immunopharmacology, 2025, 157:114749.
  7. Wentong Jia#, Liyang Ma#, Xin Yu#, Feiyang Wang, Qian Yang, Xiaoye Wang, Mengjie Fan, Yan Gu, Ran Meng, Jian Wang, Yu-Xia Li, Rong Li*, Xuan Shao*, Yan-Ling Wang*. Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss[J]. National Science Review, 2024, 11(6):142.
  8. Yeling Ma#; Xin Yu#; Shenglong Ye#; Wenlong Li; Qian Yang; Yu-Xia Li; Yongqing Wang*, Yan-Ling Wang*. Immune-regulatory properties of endovascular extravillous trophoblast cells in human placenta[J]. Placenta, 2024, 145:107-116.
  9. Yeling Ma#, Xin Yu#, Yu-Xia Li, Yan-Ling Wang*. HGF/c-Met signal regulates early differentiation of placental trophoblast cells[J]. Journal of Reproduction and Development, 2021, 67(2):89-97.
  10. Yeling Ma#, Xin Yu#, Lanmei Zhang#, Juan Liu, Xuan Shao, Yu-Xia Li, Yan-Ling Wang*. Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy[J]. Biology of Reproduction, 2020, 104(3):624-637.
  11. Mingming Fan#, Hongyu Wu#, Yuan Xie#, Ming Liu, Xin Yu, Feiyang Wang, Zhenyu Xiao, Hongmei Wang, Xuan Shao*, Yan-Ling Wang*, Maternal Nutritional Status Governs Fetal Development by Modulating Imprinting Gene GAB1-Mediated Trophoblast Differentiation in the Placenta[J], Cell Proliferation. 2025, 23:e 70069.
  12. Wenlong Li#, Shanshan Zhang#, Shenglong Ye#, Xiao Fang, Xin Yu, Xiaoye Wang*, Yeling Ma*, Yan-Ling Wang*, Evaluation of optimal trophoblastic models to mimic uterine vessel remodeling in human pregnancy[J], Biology of Reproduction. 2025, 13:ioaf 108.
  13. Qianqian Li#, Yuelin Zhu#, Xin Yu, Xuan Shao*, Yan-Ling Wang*. Molecular regulation and functional benefits of trophoblast syncytialization in optimizing maternal-fetal nutrient allocation[J]. Placenta, 2025, 6:S0143-4004(25)00208-5.
  14. Juan Liu#, Yun Yang#, Hongyu Wu#, Feihong Dang, Xin Yu, Feiyang Wang, Yongqing Wang, Yangyu Zhao, Xiaoming Shi, Wei Qin, Yanling Zhang, Yu-Xia Li, Chu Wang, Xuan Shao*, Yan-Ling Wang*. Hypoxia-Induced O-GlcNAcylation of GATA3 Leads to Excessive Testosterone Production in Preeclamptic Placentas[J]. MedComm, 2025, Feb 23;6(3):e70115.
  15. Xuan Shao#, Yun Yang#, Yanlei Liu#, Yongqing Wang#, Yangyu Zhao, Xin Yu, Juan Liu, Yu-Xia Li, Yan-Ling Wang*. Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta[J]. Journal of Pineal Research, 2023, 75(4):e12913.
  16. Xuan Shao#; Wenzhe Yu#; Yun Yang#; Feiyang Wang; Xin Yu; Hongyu Wu; Yeling Ma; Bin Cao*, Yan-Ling Wang*. The mystery of the life tree: the placentas[J]. Biology of Reproduction, 2022, 107(1):301-316.
  17. Qian Yang#, Yeling Ma#, Yanlei Liu, Xuan Shao, Wentong Jia, Xin Yu, Yu-Xia Li, Long Yang, Wenwen Gu, Haibin Wang, Jian Wang*, Yan-Ling Wang*. MNSFβ regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness[J]. Cell Proliferation, 2021, 54(12): e13145.
  18. Juan Liu#, Xuan Shao#, Wei Qin#, Yanling Zhang#, Feihong Dang, Qian Yang, Xin Yu, Yu-Xia Li, Xing Chen, Chu Wang*, Yan-Ling Wang*. Quantitative chemoproteomics reveals O-GlcNAcylation of Cystathionine γ-lyase (CSE) represses trophoblast syncytialization[J]. Cell Chemical Biology, 2021, 28(6):788-801.
  19. Peng Xu#, Zhilang Li#, Yongqing Wang#, Xin Yu, Xuan Shao, Yu-xia Li, Chun Peng, Yangyu Zhao*, Yan-Ling Wang*. miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling[J]. Molecular Therapy Nucleic Acids, 2020, 22:542-556.