The laboratory directed by Dr. Haoyi Wang at The Institute of Zoology, Chinese Academy of Sciences, is recruiting applicants for a postdoctoral research position. The Wang Lab focuses on the development of novel technologies for genome and epigenome engineering, and their application on generation of disease models using mice and human stem cells as well as establishment of therapeutic methods for genetic disorders. For more details, see the representative publications listed below. 

The Institute of Zoology in Beijing, China, offers a unique research and training environment characterized by scientific collaboration and outstanding animal research resources. The position is in a collaborative, interdisciplinary, and highly translational environment. The successful candidate should hold a recent Ph.D. in biological sciences with a research background in molecular biology, computational biology, genetics or biochemistry. Highly-motivated candidates with research experience in nucleic acid biochemistry, genome engineering, epigenetics study, RNA research and gene therapy will be most competitive for this position. 

Please send a complete CV, brief summary of research experience/interests, and names and contact information of three references to liuxiang@ioz.ac.cn .

Selected Publications:

• Wang H*, Yang H*, Shivalila CS*, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R. “One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas mediated genome engineering.” Cell, 2013 May 9; 153(4):910-8.
• Yang H*, Wang H*, Shivalila CS*, Cheng AW, Shi L, Jaenisch R. “One-step generation of mice carrying reporter and conditional allele by CRISPR/Cas mediated genome editing” Cell, 2013 September 12; 154(6), 1370-1379.
• Wang H*, Hu YC*, Markoulaki S, Welstead GG, Shivalila CS, Cheng AW, Pyntikova T, Dadon D, Voytas DF, Bogdanove AJ, Page DC, Jaenisch R. “TALEN-mediated editing of the Mouse Y Chromosome.” Nature Biotechnology, 2013 Jun; 31(6):530-2.
• Cheng AW*, Wang H*, Yang H, Shi L, Katz Y, Rangarajan S, Theunissen TW, Shivalila CS, Dadon DB, Jaenisch R. “Multiplexed activation of endogenous genes by CRISPR-on, a RNA-guided transcriptional activator system.” Cell Research, 2013 October 1; 23(10): 1163-1171.
• Theunissen T*, Powell B*, Wang H*, Mitalipova M, Faddah D, Reddy J, Fan Z, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D’Alessio A, Zhang J, Gao Q, Dawlaty M, Young R, Gray N, R. “Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency” Cell Stem Cell, 2014 in press.
• Maetzel D*, Sarkar S*, Wang H*, Mosleh LA, Cheng AW, Xu P, Gao Q, Mitalipova M, Jaenisch R. “Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.” Stem Cell Reports, 2014 in press.
• Hockemeyer D*, Wang H*, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R. “Genetic engineering of human pluripotent cells using TALE nucleases.” Nature Biotechnology. 2011 Jul 7；29(8):731-4.
• Wang H*, Mayhew D*, Chen X, Johnston M, and Mitra RD. “Calling Cards enable multiplexed identification of the genomic targets of DNA-binding proteins.” Genome Research. 2011 May;21(5):748-55.