Speaker: Martin Dym, Ph.D., Professor

　　　　　　 Department of Biochemistry and Molecular & Cellular Biology,

　　　　　　 Georgetown University, School of Medicine, Washington, DC, United States 

　　Time: 9:00 am, October, 20th, 2009  

　　Place:  Institute of Zoology, Building D, Room 122 

　　Contact: Chunsheng Han, Ph.D., SKLRB, Tel: 64807105, Email: hancs@ioz.ac.cn

　　Dr. Martin Dym’s main research interest is understanding the factors that regulate the renewal and differentiation of the spermatogonial stem cells. The overall interest of the laboratory is to understand the process of mammalian spermatogenesis with special focus on spermatogonial stem cell regulation, genetic modification, and transplantation. Dr. Dym is pursuing studies of stem cell factor and other ligands, such as leukemia inhibitory factor (LIF) and glial cell line-derived neurotrophic factor (GDNF), which may be important for spermatogonial development. In addition, he is studying gene expression in isolated type A spermatogonia and in seminiferous tubules in culture using serial anaylsis of gene expression (SAGE) and DNA array procedures in response to ligands. He has used telomerase and stem cell factor to immortalize germ cell precursors for in vitro growth.

Selected Pulications:

He Z, Jiang J, Kokkinaki M, Golestaneh, N, Hofmann, MC, and Dym M. "GDNF up-regulates c-fos transcription via the Ras/ERK1/2 pathway to promote mouse spermatogonial stem cell proliferation." Stem Cells (In Press) (2007).

He Z, Jiang J, Hofmann, MC, and Dym M. "Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase." Biol Reprod 77 (2007): 723-733.

Braydich-Stolle L, Kostereva N, Dym M, Hofmann MC. "Role of SRC family kinases and N-Myc in spermatogonial stem cell proliferation." Dev Biol 304 (2007): 34-45.

He Z, Chan WY, and Dym M. "Microarray technology offers a novel tool for the diagnosis and identification of therapeutic targets for male infertility." Human Reproduction 22 (2006): 123-132.

Vong QP, Li,Y, Lau YF, Dym M, Rennert OM, Chan WY. "Structural characterization and expression studies of Dby and its homologs in the mouse." Journal of Andrology 27 (2006): 653-661.

Kumar PA, Pitteloud N, Andrews PA, Hayes F, & Crowley WF, Dym, M. "Testis morphology in patients with idiopathic hypogonadotropic hypogonadism." Human Reproduction 21 (2006): 1033-1040.

Pang AL, Johnson W, Ravindranath N, Dym M, Rennert OM, & Chan WY. "Expression profiling of purified male germ cells: stage-specific expression patterns related to meiosis and postmeiotic development." Physiological Genomics 24 (2006): 75-85.

Braydich-Stolle L, Nolan C, Dym M, Hofmann MC. "Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate." Annals of the New York Academy of Sciences 1061 (2005): 94-99.

He Z, Feng L, Zhang XD, Geng YX, Parodi DA, Suárez-Quian C, and Dym M. "Expression of Col1a1, Col1a2, and Procollagen I in germ cells of immature and adult mouse testis." Reproduction 130 (2005): 333-341.

Hofmann MC, Li X, Braydich L, and. Dym M. "Isolation of male germ-line stem cells; influence of GDNF." Dev Biol 279 (2005): 114-124.

Hofmann MC, Dettin L, Braydich-Stolle L, Johnson E, Dirami G, and Dym M. "Immortalization of mouse germ-line stem cells." Stem Cells 23 (2005): 200-210.

Wu SM, Baxendale V, Chen Y, Li X, Pang Al, Stitely T, Munson PJ, Leung MYK, Ravindranath N, Dym M, Rennert OM, Chan WY. "Analysis of mouse germ-cell transcriptome at different stages of spermatogenesis by SAGE: biological significance." Genomics 84 (2004): 971-981.

Dettin LE, Hofmann MC, Ravindranath N, and Dym M. "Morphological characterization of the spermatogonial subtypes in the neonatal mouse testis." Biol Reprod 69 (2003): 1565-1571.

Feng LX, Dettin L, Chan Y, Dettin L, Reijo Pera RA, Herr JC, Goldberg E and Dym M. "Generation and in vitro differentiation of a spermatogonial cell line." Science 297 (2002): 392-395.