Title: Unraveling the Mechanisms Governing Neural Stem Cell Fate and Neurogenesis

Speaker: Xinyu Zhao, PhD，Associate Professor，Department of Neuroscience and Waisman Center，University of Wisconsin-Madison

Time: 2012.2.16, 10：00am

Place: IOZ D-122

Contact: Prof. DUAN En-Kui, 6480-7308

Selected publications：

1. Guo W, Zhang L , Christopher DM, Teng Z, Fausett SR, Klingensmith K, Jin P, and Zhao X. RNA-binding Protein FXR2 Regulates Proliferation and Differentiation of Adult Hippocampal Neural Stem Cells by Reducing Noggin Expression. Neuron. 2011. 70 (5): 924-938  

2. Guo W, Allan AM, Zong R, Zhang L, Johnson EB, Schaller EG, Murthy A, Goggin SL, Eisch AJ, Oostra BA, Nelson DL, Jin P, and Zhao X. Selective deletion of FMRP in adult neural stem cells disrupts hippocampal neurogenesis and learning. Nature Medicine 17(5):559-65. PMID: 21516088. (Cover story. Featured by Faculty1000 as top 2% of published articles in biology and medicine.).

3. Smrt RD, Szulwach KE Pfeiffer RL, Li X, Guo W, Pathania M, Teng Z, Luo Y, Peng J, Wilson MC, Bordey A, Jin P and Zhao X. (2010) MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase Mind Bomb-1. Stem Cells. 28(6):1060-70. PMID: 20506192.
4. Liu C, Teng Z, Santistevan NJ, Szulwach KE, Guo W, Jin P, and Zhao X. (2010) Epigenetic regulation of miR-184 by Mbd1 governs neural stem cell proliferation and differentiation.Cell Stem Cell .6(5):433-44. PMID: 20452318.
5. Szulwach KE, Li X, Smrt RD, Li Y, Luo Y, Li L, Lin L, Santistevan NJ, Li W, Zhao X#., and Jin P# (#, co-corresponding authors). Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J. Cell Biol., 2010 189 (1) 127-41. PMC Journal - In Process
6. Luo Y, Shan G, Guo W, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P and Zhao X. (2010) Fragile X mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genetics. 6(4):e1000898. PMID: 20386739

welcome！