Title: Sex Hormone-binding Globulins- Aardwolfs to Zebrafish

Speaker: Dr. Geoffrey L. Hammond

　　　  Scientific Director, Child and Family Research Institute

　　　  Professor, Department of Obstetrics & Gynaecology, University of British Columbia, Canada

Time: 2012.2.27,  3:30pm

Place: IOZ C-101

Contact: Prof. WANG Hong-Mei, 6480-7187

Dr. Hammond is recognized internationally as an expert in the area of steroid hormone action. He has published more than 200 scientific articles and reviews. He has served on numerous editorial boards and organizing committees of international meetings. He holds several patents and many of the reagents he has produced and methods he has developed are used world-wide as diagnostic tools. In 1999, he served as VP Research and Development for EG & G Life Sciences (now Perkin Elmer Life Sciences), and has worked as consultant with numerous biotechnology and pharmaceutical companies. As a measure of the public awareness of Hammond’s research, about 50% of the references on the Wikipedia pages on sex hormone binding globulin (SHBG) and corticosteroid-binding globulin (CBG) are attributed to Hammond and his collaborators.

Selected publication:

Lin HY, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H, Hammond GL (2012) High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab Feb 15 [Epub ahead of print].

Lin HY, Muller YA, Hammond GL (2010) Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol 316(1):3-12.

Lin HY, Underhill C, Gardill BR, Muller YA, Hammond GL (2009) Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage. J Biol Chem 284:884-96.

Selva DM, Hogeveen KN, Innis SM, Hammond GL (2007) Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest 117:3979-87.

Selva DM, Hogeveen KN, Hammond GL (2005) Repression of the human sex hormone-binding globulin gene in Sertoli cells by USF transcription factors. J Biol Chem 280:4462-4468.

Hogeveen KN, Cousin P, Pugeat M, Dewailly D, Soudan B, Hammond GL (2002) Human sex hormone-binding globulin variants associated with hyper androgenism and ovarian dysfunction. J Clin Invest 109:973-81.

Hammond GL (1990) Molecular properties of corticosteroid binding globulin and the sex-steroid binding proteins. Endocr Rev 11:65-79.

Hammond GL, Smith CL, Goping IS, Underhill DA, Harley MJ, Reventos J, Musto NA, Gunsalus GL, Bardin CW (1987) Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors. Proc Natl Acad Sci U S A 84:5153-7.