Topic: Big Science: Big Bioinformatics Challenge

Speaker: Janan T. Eppig, Ph.D.　The Jackson Laboratory

Time:  2012.5.14, 10:30 am

Place:  Institute of Zoology, Building B, Room 105

Contact: Prof. DUAN En-kui 64807182

Dr. Janan and her colleges have developed an integrated database of mouse genetic, genomic and biological data. The famous Mouse Genome Informatics Database (MGI) is used by the international scientific community as its primary resource for mouse information and as a tool for new biological discovery. The database contains a wide variety of data pertaining to genes, their DNA and protein sequences, and the phenotypes that result from mutations in different genes. The three central components of MGI are the Mouse Genome Database (MGD), an internationally recognized database for the laboratory mouse, the Mouse Tumor Biology (MTB) database, which facilitates the selection of experimental models for cancer research, and the International Mouse Strain Resource (IMSR), a searchable online database cataloging mouse stocks available worldwide. The database continues to expand to keep abreast of new technologies and to grow with our expanding knowledge of how the genetic blueprint of DNA manifests in traits of a living individual.

Recent selected publications:

1. Bello SM, Richardson JE, Davis AP, Weigers TC, Mattingly CJ, Dolan ME, Smith CL, Blake JA, Eppig JT. 2012. Disease model curation improvements at Mouse Genome Informatics. Database(Oxford) Mar 20;2012bar063 PMCID: PMC3308153
2. Eppig JT, Blake JA, Bult CJ, Kadin JA, Richardson JE; the Mouse Genome Database Group. 2011. The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse. Nucleic Acids Res 40(D1): D881- D886. PMCID: PMC3245042
3. Blake JA, Bult CJ, Kadin JA, Richardson JE, Eppig JT and the Mouse Genome Database Group. 2011. The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics. Nucleic Acids Res 39(suppl 1): D842-D848 PMCID: PMC3013640
4. Ringwald M, Eppig JT. 2011. Mouse mutants and phenotypes: accessing information for the study of mammalian gene function. Methods. 53(4):405-10. PMCID: PMC3062719. 
5. Bult CJ, Kadin JA, Richardson JE, Blake JA, Eppig JT; Mouse Genome Database Group. 2010.  The Mouse Genome Database: enhancements and updates. Nucleic Acids 38(DI):D586-92. PMCID: PMC2808942
6. Krupke DM, Begley DA, Sundberg JP, Bult CJ, Eppig JT.  2008.  The Mouse Tumor Biology Database.  Nature Review Cancer 8(6):456-65. PMCID:  PMC2574871
7. Rowe LB, Barter ME, Kelmenson JA, Eppig JT. 2003. The compre henisve mouse radiationhybrid map densely cross-reference to the rcombination map: A tool to support the sequence assemblies. Genome Res 13:122-133.