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Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments
[ Update Time: 2016-07-15 ]

Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8–9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of ~5× for 75 samples and ~42× for two samples. Comparative genomic analyses among sheep in contrasting environments, i.e., plateau (> 4,000 m above sea level) versus lowland (< 100 m), high-altitude region (> 1,500 m) versus low-altitude region (< 1,300 m), desert (< 10 mm average annual precipitation) versus highly humid region (> 600 mm), and arid zone (< 400 mm) versus humid zone (> 400 mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. Additionally, candidate genes and GO terms functionally related to energy metabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change.

http://mbe.oxfordjournals.org/content/early/2016/07/07/molbev.msw129.abstract

 
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