| Title: |
DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans |
| Author: |
Tan,Shengjun;Ma,Huijing;Wang,Jinbo;Wang,Man;Wang,Mengxia;Yin,Haodong;Zhang,Yaqiong;Zhang,Xinying;Shen,Jieyu;Wang,Danyang;Banes,Graham L.;Zhang,Zhihua;Wu,Jianmin;Huang,Xun;Chen,Hua;Ge,Siqin;Chen,Chun-Long;Zhang,Yong E. |
| Abstract: |
Despite long being considered as "junk", transposable elements (TEs) are now accepted as catalysts of evolution. One example is Mutator-like elements (MULEs, one type of terminal inverted repeat DNA TEs, or TIR TEs) capturing sequences as Pack-MULEs in plants. However, their origination mechanism remains perplexing, and whether TIR TEs mediate duplication in animals is almost unexplored. Here we identify 370 Pack-TIRs in 100 animal reference genomes and one Pack-TIR (Ssk-FB4) family in fly populations. We find that single-copy Pack-TIRs are mostly generated via transposition-independent gap filling, and multicopy Pack-TIRs are likely generated by transposition after replication fork switching. We show that a proportion of Pack-TIRs are transcribed and often form chimeras with hosts. We also find that Ssk-FB4s represent a young protein family, as supported by proteomics and signatures of positive selection. Thus, TIR TEs catalyze new gene structures and new genes in animals via both transposition-independent and -dependent mechanisms. Transposons are accepted as evolutionary catalysts but how they do so remains less clear. Analyzing 100 animal genomes finds that terminal inverted repeat-type transposable elements catalyze new gene structures and new genes in animals via both transposition-independent and -dependent mechanisms. |
| Corresponding author: |
Zhang,Yong E |
| Subject: |
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| Impact Factor: |
17.694 |
| Authors units: |
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| PubYear: |
2021 |
| Volume: |
12 |
| Issue: |
1 |
| Page: |
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| Journal: |
Nature Communications |
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