Location: Home > Scientists
  Scientists
Name:
 HU Baoyang
Subject:
 Stem Cell Biology and Regenerative Medicine
Tel/Fax:
 +86-10-64806251  / 
E-mail:
 byhu@ioz.ac.cn
Address:
 Beijing Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Siences, Yard A3, Datun Road, Chaoyang District, Beijing, 100101, P.R.China
More:
 Hu's Group      
Resume:

Hu Baoyang, Ph.D., Professor, is currently the Executive Director of the Beijing Institute for Stem Cell and Regenerative Medicine, the Executive Vice President of the Medical School of the University of Chinese Academy of Sciences. He got Ph. D. degree in Fudan University in 2004. In 2005, Dr. Hu joined Dr. Su-Chun Zhang's stem cell research lab at the University of Wisconsin-Madison working on neural differentiation. He joined the Institute of Zoology in 2011.

Dr Hu Engaged primarily in stem cell and regenerative medicine research, and has a series of important achievements in research on human brain development and degenerative diseases. Dr. Hu and his team revealed the role and mechanism of lncRNA-derived human-specific new gene products in cerebral cortex expansion and folding（Nature Ecology & Evolution，2023）; elucidate the mechanism of TMEM119 in maintaining microglial homeostasis and regulating the progression of Alzheimer's disease（Immunity, 2025）; first to differentiate human iPS cells into neural cells（PNAS, 2010）; developed stem cell-based regenerative medicine products and pioneered clinical research for indications such as Parkinson's disease.

Research Interests:

Unveiling the Mechanisms of Human Brain Development and Disease

Developing Innovative Therapies for Neurodegenerative Diseases

Creating Novel Cell-Based Therapeutics for Major Diseases

Awards and Honors:

2023, Beijing Natural Science Award (Second Class, Certificate No. 2023-Z04-2-03-R04 ) 4/10

2020, Outstanding Science and Technology Achievement Prize of the CAS.

2019, Stem Cell Research Innovation Award, Chinese Society for Cell Biology, Stem Cell Biology Branch.

2018, Stem Cell Achievement Transformation Award, Chinese Society for Cell Biology, Stem Cell Biology Branch.

2018, First Prize of the 7th Overseas Chinese Contribution Award, All-China Federation of Returned Overseas Chinese.

2018, First Prize of Chinese Medical Science and Technology Award, (Certificate No. 201801069P1508) 8/15.

2017, Third Prize of Chinese Medical Science and Technology Award, (Certificate No. 201703185P0804) 4/8.

Professional Activities:

Board director, Chinese Society for Cell Biology (CSCB)

Board director, Chinese Society for Cell Biology Stem Cell Branch (CSSCR)

Member, the Society for Neuroscience (SfN)

Research Grants:

Selected Publications:
  1. Jing Liu#, Zhimeng Wang#, Wenwen Liang, Zhenhao Zhang, Yusen Deng, Xiaowei Chen, Zongren Hou, Yuanzhi Xie, Qi Wang, Yuan Li, Chaobo Bai, Da Li, Fan Mo, Huinan Wang, Dongmei Wang, Junliang Yuan*, Yukai Wang*, Zhaoqian Teng*, Baoyang Hu*. Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer's disease. Immunity, 2025. 58(7):1830-1846.e7.
  2. Yuanzi Xie#, Jing Liu#, Zongren Hou#, Huan Wang#, Kailun Liu, Xiaowei Chen, Zhen Fan, Da Li, Can Li, Yuhualei Pan, Yushang Zhao, Yanbing Zhu*, Baoyang Hu*. CD4-Derived Double-Negative T Cells Ameliorate Alzheimer's Disease-Like Phenotypes in the 5xFAD Mouse Model. CNS Neuroscience & Therapeutics, 2025. 31(1):e70187.
  3. Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi , Chuanyue Wang, Yukai Wang*, Baoyang Hu*. Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long- Term Functional Evaluation. Cell Proliferation, 2025. 58(7):e70005.
  4. Kailun Liu, Xiaowei Chen, Zhen Fan, Fei Ren*, Jing Liu*, Baoyang Hu*. From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research. Chinese Medical Journal, 2025. 138(7):792-807.
  5. Yanyu Li#, Liwei Zhou#, Fengcui Qian#, Qiaoli Fang#, Zhengmin Yu, Ting Cui, Fujuan Dong, Fuhong Cai, Tingting Yu, Lidong Li, Qiuyu Wang, Yanbing Zhu*, Huifang Tang*, Baoyang Hu*, Chunquan Li*. scImmOmics: a manually curated resource of single-cell multi-omics immune data. Nucleic Acids Research, 2024. 53(D1):D1162-D1172.
  6. Lin Feng#, Da Li#, Yao Tian#, Chengshun Zhao, Qi Gu, Wei Li, Jie Hao, Baoyang Hu*, Yukai Wang*. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. Neural Regeneration Research, 2024. 19 (2): 458-464.
  7. Liangjiang Huang#, Song Zhang#, Jun Wu#, Baojie Guo#, Tingting Gao, Sayed Zulfiqar Ali Shah, Bo Huang, Yajie Li, Bo Zhu, Jiaqi Fan, Liu Wang, Yani Xiao, Wenjing Liu, Yao Tian, Zhengyu Fang, Yingying Lv, Lingfeng Xie, Sheng Yao, Gaotan Ke, Xiaolin Huang, Ying Huang, Yujuan Li, Yi Jia, Zhongwen Li, Guihai Feng, Yan Huo, Wei Li, Qi Zhou, Jie Hao*, Baoyang Hu*, Hong Chen*. Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial. Signal Transduction and Targeted Therapy, 2023. 8(1):417.
  8. Ni A An#, Jie Zhang#, Fan Mo#, Xuke Luan#, Lu Tian, Qing Sunny Shen, Xiangshang Li, Chunqiong Li, Fanqi Zhou, Boya Zhang, Mingjun Ji, Jianhuan Qi, Weizhen Zhou, Wanqiu Ding, Jiayu Chen, Jia Yu, Li Zhang, Shaokun Shu, Baoyang Hu*, Chuanyun Li*. De novo genes with an lncRNA origin encode unique human brain developmental functionality. Nature Ecology & Evolution, 2023. 7(2): 264-278.
  9. Jianhuan Qi#, Fan Mo#, Ni A An#, Tingwei Mi, Jiaxin Wang, Juntian Qi, Xiangshang Li, Boya Zhang, Longkuo Xia, Yingfei Lu, Gaoying Sun, Xinyue Wang, Chuanyun Li*, Baoyang Hu*. A Human-Specific De Novo Gene Promotes Cortical Expansion and Folding. Advanced Science, 2023. 13: e2204140.
  10. Juan Yu#, Nianye Yu#, Yao Tian#, Yifan Fang#, Bin An, Guihai Feng, Jun Wu, Liu Wang, Jie Hao, Liqiang Wang, Qi Zhou, Wei Li*, Yukai Wang*, Baoyang Hu*. Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction. Cell & Bioscience, 2023. 13(1):201.
  11. Wenliang Zhu#, Mengqi Li#, Jun Zou#, Da Zhang, Minghui Fang, Yun Sun, Can Li, Mingming Tang, Yukai Wang, Qi Zhou, Tongbiao Zhao*, Wei Li*, Zheng Hu*, Baoyang Hu*. Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig. Stem Cell Reports, 2023. 18(12):2344-2355.
  12. Gaoying Sun#, Mingming Tang#, Xinyue Wang#, Da Li, Wenwen Liu, Jianhuan Qi, Haibo Wang*, Baoyang Hu*. Generation of human otic neuronal organoids using pluripotent stem cells. Cell Proliferation, 2023. 56(5):e13434.
  13. Jing Liu#, Zongren Hou#, Jun Wu#, Kailun Liu, Da Li, Tingting Gao, Wenjing Liu, Bin An, Yun Sun, Fan Mo, Liu Wang, Yukai Wang*, Jie Hao*, Baoyang Hu*, Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Proliferation, 2021. 54(8): p. e13085.
  14. Han Sun, Jing Liu, Fengting Lv, Libing Liu, Qi Gu, Baoyang Hu*, Shu Wang*, Selective reaction of conjugated polymers with basic proteins for broad-spectrum antivirulence therapy. NPG Asia Materials, 2021. 13(21).
  15. Jun Wu#, Dingyun Song#, Zhongwen Li#, Baojie Guo#, Yani Xiao, Wenjing Liu, Lingmin Liang, Chunjing Feng, Tingting Gao, Yanxia Chen, Ying Li, Zai Wang, Jianyan Wen, Shengnan Yang, Peipei Liu, Lei Wang, Yukai Wang, Liang Peng, Glyn Nigel Stacey, Zheng Hu, Guihai Feng, Wei Li, Yan Huo, Ronghua Jin, Ng Shyh-Chang, Qi Zhou, Liu Wang, Baoyang Hu*, Huaping Dai*, Jie Hao*. Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. Cell Research, 2020. 30 (9): p. 794-809.
  16. Wenliang Zhu#, Boya Zhang#, Mengqi Li#, Fan Mo, Tingwei Mi, Yihui Wu, Zhaoqian Teng, Qi Zhou*, Wei Li*, Baoyang Hu*. Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. Nature Communications, 2019. 10(1): p. 928.
  17. Weiqi Zhang#, Haifeng Wan#, Guihai Feng#, Jing Qu#, Jiaqiang Wang, Yaobin Jing, Ruotong Ren, Zunpeng Liu, Linlin Zhang, Zhiguo Chen, Shuyan Wang, Yong Zhao, Zhaoxia Wang, Yun Yuan, Qi Zhou, Wei Li*, Guanghui Liu*, Baoyang Hu*. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature, 2018. 560(7720): p. 661-665.
  18. Zhikun Li#, Leyun Wang#, Libin Wang#, Guihai Feng#, Xuewei Yuan#, Chao Liu, Kai Xu, Yuhuan Li, Haifeng Wan, Ying Zhang, Yufei Li, Xin Li, Wei Li*, Qi Zhou*, Baoyang Hu*. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell, 2018. 23(5): p. 665-676.
  19. Xuepeng Wang#, Tianda Li#, Tongtong Cui#, Dawei Yu#, Chao Liu#, Liyuan Jiang, Guihai Feng, Lei Wang, Rui Fu, Xinxin Zhang, Jie Hao, Yukai Wang, Liu Wang, Qi Zhou*, Wei Li*, Baoyang Hu*. Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. Cell Research, 2018. 28(1): p. 126-129.
  20. Menghua Wu, Da Zhang, Chunying Bi, Tingwei Mi, Wenliang Zhu, Longkuo Xia, Zhaoqian Teng, Baoyang Hu*, Yihui Wu*. A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs. Stem Cell Reports, 2018. 11(3): p. 635-650.
  21. Yukai Wang, Wanwan Zhu, Menghua Wu, Yihui Wu, Zhengxin Liu, Lingmin Liang, Chao Sheng, Jie Hao, Liu Wang, Wei Li, Qi Zhou*, Baoyang Hu*. Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. Stem Cell Reports, 2018. 11(1):171-182.
  22. Boya Zhang#, Yangzhige He#, Yanpeng Xu#, Fan Mo, Tingwei Mi, Qing Sunny Shen, Chunfeng Li, Yali Li, Jing Liu, Yihui Wu, Guilai Chen, Wenliang Zhu, Chengfeng Qin*, Baoyang Hu*, Guomin Zhou*. Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids. Cell Death and Disease, 2018. 9(7):719.
  23. Yuan Jiang#, Long Yan#, Longkuo Xia, Xiaoyin Lu, Wenliang Zhu, Dewen Ding, Mingxia Du, Da Zhang, Hongmei Wang*, Baoyang Hu*. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. The Journal of Biological Chemistry, 2018. 293(50): p. 19317-19329.
  24. Zhikun Li#, Haifeng Wan#, Guihai Feng#, Leyun Wang#, Zhengquan He, Yukai Wang, Xiujie Wang, Wei Li*, Qi Zhou*, Baoyang Hu*. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Research, 2016. 26(1):135-138.
  25. Lixiang Ma, Baoyang Hu, Yan Liu, Scott Christopher Vermilyea, Huisheng Liu, Lu Gao, Yan Sun, Xiaoqing Zhang, Suchun Zhang*. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell, 2012. 10(4):455-464.
  26. Yuan Jiang, Meijiang Zhang, Baoyang Hu*. Specification of functional neurons and glia from human pluripotent stem cells. Protein Cell, 2012. 3(11):818-825.
  27. Baoyang Hu, Jason P Weick, Junying Yu, Lixiang Ma, Xiaoqing Zhang, James A Thomson, Suchun Zhang*. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of National Academy of Sciences of The United States of America, 2010. 107(9):4335-4340.
  28. Baoyang Hu, Suchun Zhang*, Differentiation of spinal motor neurons from pluripotent human stem cells. Nature Protocols, 2009. 4(9):1295-1304.
  29. Baoyang Hu, Zhongwei Du, Suchun Zhang*. Differentiation of human oligodendrocytes from pluripotent stem cells. Nature Protocols, 2009. 4(11): 1614-1622.
  30. Baoyang Hu, Zhongwei Du, Xuejun Li, Melvin Ayala, Suchun Zhang*. Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development, 2009. 136(9):1443-1452.

Notes:  # These authors contributed equally; * Correspondence.