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Name:
 ZHAO Tongbiao
Subject:
 Regenerative medicine
Tel/Fax:
 +86-10-64805262  / 
E-mail:
 tbzhao@ioz.ac.cn or tongbiaozhao@gmail.com
Address:
 The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
 Group of Stem Cell and Immunology      
Resume:

Dr. Tongbiao Zhao is a professor and a doctoral advisor at the Institute of Zoology, Chinese Academy of Sciences, where he leads the Lab of Stem Cell and Immunology. He is also the Deputy Director of the Beijing Institute of Stem Cells and Regenerative Medicine and a joint professor at the University of the Chinese Academy of Sciences. Recognized as a national high-level overseas talent and a leading talent in technological innovation, he is also the chief scientist for several national key R&D projects.

Dr. Zhao graduated with a bachelor's degree from Qufu Normal University in 2000 and earned his Ph.D. from the Northwest Plateau Institute of Biology, Chinese Academy of Sciences, in 2004. He completed his postdoctoral research at the Institute of Biophysics, Chinese Academy of Sciences, from 2004 to 2006, where he was promoted to associate professor. He furthered his research in immunology at the Blood Research Institute in Wisconsin from 2006 to 2007 and in stem cell research at the University of California, San Diego, from 2007 to 2011, where he served as an Assistant Specialist III. In 2012, he joined the Institute of Zoology to establish the Lab of Stem Cell and Immunology.

Research Work

Dr. Zhao`s research primarily focuses on stem cell immunology and stem cell translational research, and he has made significant progress. For example, he firstly discovered the immunogenicity of mouse and human induced pluripotent stem cells (iPSCs), with findings published in prestigious journals such as Nature (2011), Cell Stem Cell (2015), and Cell Discovery (2015). He has revealed that high oxidative phosphorylation and high autophagic flux are intrinsic features of pluripotent stem cells in maintaining their identity, as published in Protein & Cell (2022), Nature Communications (2019), and Autophagy (2016).

Additionally, Dr. Zhao has pioneered research in developing standards to support the translational application of stem cells, achieving a series of groundbreaking advancements. He has led the establishment of several world-first international standards associated with stem cells, including "Requirements for Human and Mouse Pluripotent Stem Cells (ISO 24603:2022)", "Data Interoperability for Stem Cell Data — Part 1: Framework (ISO 8472-1:2024)", "Requirements for Human Neural Stem Cells Derived from Pluripotent Stem Cells (ISO 18162:2024)", and others at various stages of standardization. His team has also created the first national standard for human stem cells in China and over 30 community standards within the country.

Research Interests:

Dr. Zhao's research group aims to address challenges associated with fundamental biology and applications of stem cells, focusing on:

1. Understanding immune tolerance mechanisms and applying them to stem cell transplantation

2. Understanding the metabolic regulation of pluripotent stem cells and harnessing them to instruct immune cell differentiation, serving the requirements of cancer immunotherapy

3. Developing standards to support stem cell and organoid applications

Awards and Honors:

2012 SCOPUS Young Researcher Award
2005 Postdoctoral award from China Postdoctoral Science Foundation
2004 Chinese Academy of Sciences K.C. Wong Fellowship
2003 President Scholarship of Chinese Academy of Sciences

Professional Activities:

Dr. Zhao is actively involved in various professional organizations. He is the Chair of the Standard Working Committee of the Chinese Society for Cell Biology, a council member of the Chinese Society for Cell Biology and the China Zoological Society, and a committee member of the Chinese Society for Stem Cell Research. He also serves on the Biobanking Professional Committee of CNAS Laboratory Specialized Committee and the Organoid Committee of Chinese Genetics Society of China.

Internationally, Dr. Zhao is the Convenor of the ISO/TC276/AHG1 (Ad Hoc Group 1 Organoids) and a member of ISO/TC276/WG2, WG4, and SC1. He is also a member of the Standard Steering Committee of the International Society for Stem Cell Research (ISSCR) and a Vice Chair of the Belt and Road Regional Standardization Committee. He contributes as an Associate Editor for international journals such as Animal Models and Experimental Medicine and Frontiers in Cell and Developmental Biology, and as an editorial board member for Cell Proliferation and the Electronic Journal of Developmental Medicine.

Research Grants:

Selected Publications:

（#First author，*Corresponding author）：

  1. Zhao Y, Cao J, Xu H, Cao W, Cheng C, Tan S, Zhao T*. Optimizing in vitro T cell differentiation by using induced pluripotent stem cells with GFP-RUNX1 and mCherry-TCF7 labelling. Cell Proliferation, 2024, e13661. DOI: 10.1111/cpr.13661
  2. Zhu W#, Li M#, Zou J#, Zhang D, Fang M, Sun Y, Li C, Tang M, Wang Y, Zhou Q, Zhao T*, Li W*, Hu Z*, Hu B*. Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig. Stem Cell Reports, 2023,18(12):2344-2355. DOI: 10.1016/j.stemcr.2023.10.016
  3. Ren J#, Song M#, Zhang W#, Cai JP, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Chen XC, Ci W, Ding BS, Ding Q, Gao F, Gao S, Han JJ, He QY, Huang K, Ju Z, Kong QP, Li J, Li J, Li J, Li X, Liu B, Liu F, Liu JP, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren R, Song W, Songyang Z, Sun L, Sun YE, Sun Y, Tian M, Tian XL, Tian Y, Wang J, Wang S, Wang S, Wang W, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xiao ZX, Xie Z, Xiong W, Xu D, Yang Z, Ye J, Yu W, Yue R, Zhang C, Zhang H, Zhang L, Zhang X, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhou Z, Zhu D, Zou W, Pei G, Liu GH*. The Aging Biomarker Consortium represents a new era for aging research in China. Nat Med, 2023,29(9):2162-2165. DOI: 10.1038/s41591-023-02444-y
  4. Han M#, Hu L#, Wu D#, Zhang Y, Li P, Zhao X, Zeng Y, Ren G, Hou Z, Pang Y, Zhao T, Zhong C*. IL-21R-STAT3 signalling initiates a differentiation program in uterine tissue-resident NK cells to support pregnancy. Nature Communications, 2023 4;14(1):7109. DOI: 10.1038/s41467-023-42990-0
  5. Xu H#, Tan S, Zhao Y, Zhang L, Cao W, Li X, Tian J, Wang X, Li X, Wang F, Cao J*, Zhao T*. Lin-PU.1dimGATA-1-defines haematopoietic stem cells with long-term multilineage reconstitution activity. Cell Proliferation, 2023, e13490. DOI: 10.1111/cpr.13490
  6. Cao W#, Cao J#, Li X, Xu H, Tian J, Li X, Wang F, Zhao T*. A novel inducible haematopoietic cell-depleting mouse model for chimeric complementation of blood cells. Cell Proliferation, 2023,56(5): e13472. DOI: 10.1111/cpr.13472
  7. Cao J#, Li M#, Liu K, Shi X, Sui N, Yao Y, Wang X, Li S, Tian Y, Tan S, Zhao Q, Wang L, Chai X, Zhang L, Liu C, Li X. Chang Z, Li D, Zhao T*. Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine. Protein Cell, 2023,14(5): 376-381.DOI: 10.1093/procel/pwac009
  8. Liu K#, Li X#, Li Z#, Cao J, Li X, Xu Y, Liu L, Zhao T*. Evaluating mitophagy in embryonic stem cells by using fluorescence-based imaging. Frontiers In Cell and Developmental Biology,2022,10:910464. DOI: 10.3389/fcell.2022.910464
  9. Zhao Q#, Liu K#, Zhang L#, Li Z, Wang L, Cao J, Xu Y, Zheng A, Chen Q, Zhao T*. BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination. Cell Death and Disease,2022,13(11):976. DOI: 10.1038/s41419-022-05413-4
  10. Liu K#, Zhao Q#, Sun H#, Liu L, Wang C, Li Z, Xu Y, Wang L, Zhang L, Zhang H, Chen Q, Zhao T*. BNIP3(BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy. Cell Death and Disease,2022, 13(4):334. DOI: 10.1038/s41419-022-04795-9
  11. Wen D#, Ding LS#, Zhang Y, Li X, Zhang X, Yuan F, Zhao T, Zheng A*. Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine. Nature Communications, 2022,13(1):7780. DOI: 10.1038/s41467-022-35407-x
  12. Wang C#, Liu K#, Cao J#, Wang L, Zhao Q, Li Z, Zhang H, Chen Q, Zhao T*. PINK1-mediated mitophagy maintains pluripotency through optineurin. Cell Proliferation, 2021,54(5): e13034. DOI: 10.1111/cpr.13034 
  13. Jin L#, Cao L#, Zhu Y#, Cao J#, Li X, Zhou J, Liu B, Zhao T*. Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6. Science Bulletin, 2021,66(8):803-812. DOI: 10.1016/j.scib.2020.12.027
  14. Zhou J#, Jin L, Wang F, Zhang Y, Liu B, Zhao T*. Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects. Protein Cell, 2019, 10(10): 764-769. DOI: 10.1007/s13238-019-0643-y
  15. Gu H#, Shi X#, Liu C#, Wang C#, Sui N, Zhao Y, Gong J, Wang F, Zhang H, Li W*, Zhao T*. USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5. Nature Communications, 2019, 10(1): 1465. DOI: 10.1038/s41467-019-09430-4
  16. Gong J#, Gu H#, Zhao L#, Wang L, Liu P, Wang F, Xu H, Zhao T*. Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency. Cell Death and Disease, 2018, 9(2): 38. DOI: 10.1038/s41419-017-0054-z
  17. Liu P#, Liu K#, Gu H, Wang W, Gong J, Zhu Y, Zhao Q, Cao J, Han C, Gao F, Chen Q, Li W, Jiao J, Hu B, Zhou Q, Zhao T*. High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. Cell Death and Differentiation, 2017, 24(10): 1672-1680. DOI: 10.1038/cdd.2017.90
  18. Sun H#, Cao J#, Zhao L#, Zhu S, Chen S, Li Y, Zhao B, Zhao T*. PIM2 regulates stemness through phosphorylation of 4E-BP1. Science Bulletin, 2017, 62(10): 679-685. (Cover story) DOI: 10.1016/j.scib.2017.04.018
  19. Liu K#, Zhao Q#, Liu P#, Cao J, Gong J, Wang C, Wang W, Li X, Sun H, Zhang C, Li Y, Jiang M, Zhu S, Sun Q, Jiao J, Hu B, Zhao X, Li W, Chen Q, Zhou Q*, Zhao T*. ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy, 2016, 12(11): 2000-2008. DOI: 10.1080/15548627.2016.1212786
  20. Zhu S, Cao J, Sun H, Liu K, Li Y, Zhao T*. p18 inhibits reprogramming through inactivation of Cdk4/6. Scientific Reports, 2016, 6: 31085. DOI: 10.1038/srep31085
  21. Zhang C, Cao J, Li X, Xu H, Wang W, Wang L, Zhao X, Li W, Jiao J, Hu B, Zhou Q*, Zhao T*. Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells. Science China Life Sciences, 2016, 59(9): 950-957. DOI: 10.1007/s11427-016-0114-9
  22. Zhao T#, Zhang Z#, Westenskow P#, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg D, Yang Y, Zhang K, Friedlander M, Xu Y*. Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells. Cell Stem Cell, 2015, 17(3): 353-359. DOI: 10.1016/j.stem.2015.07.021
  23. Wang L#, Cao J#, Wang Y#, Lan T#, Liu L, Wang W, Jin N, Gong J, Zhang C, Teng F, Yan G, Li C, Li J, Wan H, Hu B, Li W, Zhao X, Qi Z*, Zhao T*, Zhou Q*. Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. Cell Discovery, 2015, 1: 15015. DOI: 10.1038/celldisc.2015.15
  24. Zhao T, Zhang Z, Rong Z, Xu Y*. Immunogenicity of induced pluripotent stem cells. Nature, 2011, 474(7350): 212-216. DOI: 10.1038/nature10135

Highlighted by Nature (Nature 474:165); Nature Medicine (Nature Medicine 17: 670)

Recommended by Faculty of 1000 (F1000.com/11136956)

Reported by Nature, Science, New York Time, New Scientist, ScienceDaily, UK Guardian, USA today et al.

  1. Hou Q#, Zhao T#, Zhang H, Lu H, Zhang Q, Sun L, Fan Z*. Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. Molecular Immunology, 2008, 45(4): 1044-1055. DOI:10.1016/j.molimm.2007.07.032
  2. Zhao T#, Zhang H#, Guo Y, Fan Z*. Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. Journal of Biological Chemistry, 2007, 282(16): 12104-12111. DOI:10.1074/jbc.M611006200
  3. Zhao T#, Zhang H, Guo Y, Zhang Q, Hua G, Lu H, Hou Q, Liu H, Fan Z*. Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. Cell Death and Differentiation, 2007, 14(3):489-499. DOI: 10.1038/sj.cdd.4402040

Reviews：

  1. Ludwig TE#*, Andrews PW#, Barbaric I, Benvenisty N, Bhattacharyya A, Crook JM, Daheron LM, Draper JS, Healy LE, Huch M, Inamdar MS, Jensen KB, Kurtz A, Lancaster MA, Liberali P, Lutolf MP, Mummery CL, Pera MF, Sato Y, Shimasaki N, Smith AG, Song J, Spits C, Stacey G, Wells CA, Zhao T, Mosher JT. ISSCR standards for the use of human stem cells in basic research. Stem Cell Reports, 2023,18(9):1744-1752. DOI: 10.1016/j.stemcr.2023.08.003
  2. Aging Biomarker Consortium; Bao H#, Cao J#, Chen M#, Chen M#, Chen W#, Chen X#, Chen Y#, Chen Y#, Chen Y#, Chen Z#, Chhetri JK#, Ding Y#, Feng J#, Guo J#, Guo M#, He C#, Jia Y#, Jiang H#, Jing Y#, Li D#, Li J#, Li J#, Liang Q#, Liang R#, Liu F#, Liu X#, Liu Z#, Luo OJ#, Lv J#, Ma J#, Mao K#, Nie J#, Qiao X#, Sun X#, Tang X#, Wang J#, Wang Q#, Wang S#, Wang X#, Wang Y#, Wang Y#, Wu R#, Xia K#, Xiao FH#, Xu L#, Xu Y#, Yan H#, Yang L#, Yang R#, Yang Y#, Ying Y#, Zhang L#, Zhang W#, Zhang W#, Zhang X#, Zhang Z#, Zhou M#, Zhou R#, Zhu Q#, Zhu Z#, Cao F*, Cao Z*, Chan P*, Chen C*, Chen G*, Chen HZ*, Chen J*, Ci W*, Ding BS*, Ding Q*, Gao F*, Han JJ*, Huang K*, Ju Z*, Kong QP*, Li J*, Li J*, Li X*, Liu B*, Liu F*, Liu L*, Liu Q*, Liu Q*, Liu X*, Liu Y*, Luo X*, Ma S*, Ma X*, Mao Z*, Nie J*, Peng Y*, Qu J*, Ren J*, Ren R*, Song M*, Song YZ*, Sun YE*, Sun Y*, Tian M*, Wang S*, Wang S*, Wang X*, Wang X*, Wang YJ*, Wang Y*, Wong CCL*, Xiang AP*, Xiao Y*, Xie Z*, Xu D*, Ye J*, Yue R*, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang YW, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G*, Liu GH*. Biomarkers of aging. Sci China Life Sci, 2023,66(5):893-1066. DOI: 10.1007/s11427-023-2305-0
  3. Cao J#, Hao J#, Wang L#, Tan Y, Tian Y, Li S, Ma A, Fu B, Dai J, Zhai P, Xiang P, Zhang Y, Cheng T*, Peng Y*, Zhou Q*, Zhao T* Developing standards to support the clinical translation of stem cells. Stem Cells Translational Medicine, 2021,10: S85-S95. DOI:10.1002/sct3.13035
  4. Cao J, Stacey G, Chang N, Zhao T*. Developing standards to support cell technology applications, Cell Proliferation, 2022,55(4): e13210. DOI:10.1111/cpr.13210
  5. Liu K#, Cao J#, Shi X#, Wang L, Zhao T*. Cellular metabolism and homeostasis in pluripotency regulation. Protein Cell, 2020,11(9): 630-640. DOI:10.1007/s13238-020-00755-1
  6. Wang L#, Ye X#, Zhao T*. The physiological roles of autophagy in the mammalian life cycle. Biological Reviews, 2019, 94(2): 503-516. DOI: 10.1111/brv.12464
  7. Liu K, Wang L, Zhao T*. Autophagy in Normal Stem Cells and Specialized Cells. Adv Exp Med Biol,2019.1206:489-508. DOI: 10.1007/978-981-15-0602-4
  8. Cao J, Zhao T*. Single-cell sequencing delivers hematopoietic stem cell specification. Science Bulletin, 2016, 61(18): 1419-1421. DOI: 10.1007/s11434-016-1163-2
  9. Liu K#, Song Y#, Yu H#, Zhao T*. Understanding the roadmaps to induced pluripotency. Cell Death Disease, 2014, 5: e1232. DOI: 10.1038/cddis.2014.205
  10. Cao J#, Li X#, Lu X, Zhang C, Yu H, Zhao T*. Cells derived from iPSC can be immunogenic–Yes or No? Protein Cell, 2014, 5(1): 1-3. DOI:10.1007/s13238-013-0003-2
  11. Lu X, Zhao T*. Clinical therapy using iPSCs: hopes and challenges. Genomics Proteomics Bioinformatics, 2013, 11(5): 294-298. DOI: 10.1016/j.gpb.2013.09.002
  12. Zhao T, Xu Y*. p53 and stem cells: new developments and new concerns. Trends in Cell Biology, 2010, 20(3): 170-175. DOI: 10.1016/j.tcb.2009.12.004

Standard papers：

  1. Niu S#, Xia C#, Huang D#, Wang L#, Hu H, Yu S, Wu N, Dong Z, Zhou J, Wu J, Yu J, Zhang Y, Wang C, Fu B, Cao J, Liang L, Xu L, Chen L, Zhou Q, Ma A*, Zhao T*, Hao J*, Wang J*. Requirements for human natural killer cells. Cell Prolif, 2024, 57(5): e13588. DOI: 10.1111/cpr.13588. Epub 2023 Dec 20
  2. Wang YK#, Yu J#, Zhang TT#, Ma AJ, Hao J, Chen YJ, Liu CM, Liu Y, Wang CL, Zhai PJ, Xiang AP, Li TQ, Tang TS, Chen H, Bao XJ, Wang YL, He WY, Fan J, Teng ZQ, Wang L, Zhou JX, Fu BQ, Fu YV, Feng L, Cao JN, Liang LM, Wang L, Zhou Q, Zhang Y*, Hu BY*, Zhao TB*. Human neural stem cells. Cell Prolif, 2024, 57(4): e13564. DOI: 10.1111/cpr.13564
  3. Peng Y#*, Ma A#, Xiao Z#, Hao J#, Feng R, Wang C, Hu B, Zhai P, Li K, Wang L, Cao J, Xiang P, Zhang Y, Wei J, Wang X, Fu B, Chen Q, Wei Q, Gao H, Lv J, Liu X, Ma Y, Cheng T, Huang X, Su Y, Zhang H, Zhou Q*, Zhao T*. Technical specifications for ethics review of human stem cell research. Cell Prolif, 2024,57(3): e13556. DOI:  10.1111/cpr.13556
  4. Wang L#, Liu S#, Li K#, Ma A#, Hu C#, Wang C, Cao N, Zhao Y, Fu R, Jia W, Xiang P, Liu H, Qi Z, Zhu N, Liang L, Wang L, Cao J, Zhai P, Zhou J, Wei J, Na T, Wu J, He Z, Zhou G, Yu W, Wu J, Zeng W, Zhang Y, Zhu L, Fu B, Zhang J, Yang S, Dai C, Cui H, Jing J, Yan H, He X, Lu Y, Tong C, Zhao T*, Hao J*, Liu X*, Jin Y*, Wang Y*. General requirements for the production of extracellular vesicles derived from human stem cells. Cell Prolif, 2024, 57(3): e13554. DOI: 10.1111/cpr.13554
  5. Wang YK, Feng L, Ma AJ, Hao J, Zhang Y, Chen YJ, Chen ZG, Yu JY, Liu Y, Liu CM, Zhang Y, Wang CL, Teng ZQ, Zhou JX, Li TQ, Wang L, Fu BQ, Fu YV, Zhu LJ, Liang LM, Cao JN, Wang L, Zhou Q, Xiang AP*, Hu BY*, Zhao TB*. Human midbrain dopaminergic progenitors. Cell Prolif, 2024, 57(4): e13563. DOI: 10.1111/cpr.13563
  6. Lin H#, Wang Y#, Cheng C#, Qian Y#, Hao J, Zhang Z, Sheng W, Song L, Deng CX, Zhao B, Cao J, Wang L, Wang L, Liang L, Chen WK, Yu C, Sun Z, Yang Y, Wang C, Zhang Y, Li Q, Li K, Ma A*, Zhao T*, Chen YG*, Hua G*. Standard: Human intestinal cancer organoids. Cell Regen, 2023, 12(1):24. DOI: 10.1186/s13619-023-00167-6
  7. Wang Y#, Lin H#, Zhao L#, Hong F#, Hao J, Zhang Z, Sheng W, Song L, Deng C, Zhao B, Cao J, Wang L, Wang L, Liang L, Chen W, Yu C, Sun Z, Yang Y, Wang C, Zhang Y, Li Q, Li K, Ma A*, Zhao T*, Hua G*, Chen Y*. Standard: Human intestinal organoids. Cell regeneration,2023,12(1):23. DOI:10.1186/s13619-023-00168-5
  8. Zhang Y#, Wei J#, Cao J#, Zhang K#, Peng Y, Deng H, Kang J, Pan G, Zhang Y, Fu B, Hu S, Na J, Liu Y, Wang L, Liang L, Zhu H, Zhang Y, Jin Z, Hao J*, Ma A*, Zhao T*, Yu J*. Requirements for human-induced pluripotent stem cells. Cell Proliferation, 2022,55(4): e13182. DOI:10.1111/cpr.13182
  9. Wang L#, Cao J#, Peng Y#, Fu B, Jin Z, Hu Y, Wu W, Xiang P, Hu S, Yu J, Zhang Y, Wei J, Zhang Y, Li Q, Zhou J, Zhai P, Zhu H, Liang L, Ma A, Glyn Stacey*, Zhao T*, Hao J*.Human retinal pigment epithelial cells. Cell Proliferation, 2022, 55(4): e13153. DOI:10.1111/cpr.13153
  10. Yu M#, Lei W#, Cao J#, Wang L#, Ma A, Zhao Z, Yang H, Shen Z, Lan F, Cao F. Liang P, Pei X, Xiang P, Yu J, Zhang Y, Zhang Y, Li Q, Zhou J, Wei J, Peng Y, Zhu H, Liang L, Cao N, Fu B*, Hao J*, Zhao T*, Hu S*. Requirements for Human Cardiomyocytes. Cell Proliferation, 2022,55(4): e13150. DOI:10.1111/cpr.13150
  11. Peng Z#, Wu J#, Hu S#, Ma A#, Wang L, Cao N, Zhang Y, Li Q, Yu J, Meng S, Na T, Shi X, Li M, Liu H, Qian L, Tian E, Lin F, Cao J, Peng Y, Zhu H, Liang L, Hao J*, Zhao T*, Cheng X*, Pan G*. Requirments for Primary Human Hepatocyte. Cell Proliferation, 2022,55(4): e13147. DOI:10.1111/cpr.13147
  12. Chen X#, Huang J#, Wu J#, Hao J#, Fu B, Wang Y, Zhou B, Tao N, Wei J, Zhang Y, Li Q, Hu S, Zhou J, Yu J, Wu Z, Zhu H, Cao J, Wang L, Peng Y, Liang L, Ma A*, Zhang Y*, Zhao T*, Xiang P*. Human mesenchymal stem cells. Cell Proliferation, 2022,55: e13141. DOI:10.1111/cpr.13141
  13. Nan X#, Zhang BW#, Hao J#, Wen Y#, Fu B, Qu M, Zhang Y, Wang H, Fang F, Wei J, Li Q, Hu S, Yu J, Gao Y, Liu Q, Cao J, Wang L, Peng Y, Zhu H, Liang L, Ma A*, Zhou J*, Zhao T*, Pei X*. Requirements for human haematopoietic stem/progenitor cells. Cell Proliferation, 2022,55(4): e13152. DOI:10.1111/cpr.13152
  14. Hao J#, Ma A#, Wang L#, Cao J#, Chen S, Wang L, Fu B, Zhou J, Pei X, Zhang Y, Xiang P, Hu S, Li Q, Zhang Y, Xia Y, Zhu H, Stacey G, Zhou Q*, Zhao T*. General requirements for stem cells. Cell Proliferation, 2020, 53(12): e12926. DOI:10.1111/cpr.12926
  15. Hao J#, Cao J#, Wang L#, Ma A#, Chen S, Ding J, Wang L, Fu B, Zhang Y, Pei X, Xiang P, Li Q, Zhang Y, Zhou J, Hu S, Yu J, Wei J, Zhu H, Stacey G, Zhao T*, Zhou Q*. Requirements for human embryonic stem cells. Cell Proliferation, 2020,53(12): e12925. DOI:10.1111/cpr.12925

ISO standards（*Project Leader）：

  1. Tongbiao Zhao*，Qi Zhou*, et al. ISO 24603:2022 Biotechnology — Biobanking — Requirements for human and mouse pluripotent stem cells. www.iso.org/standard/79046.html
  2. Yong Zhang*, Tongbiao Zhao*, et al. ISO 8472-1:2024 Biotechnology — Data interoperability for stem cell data — Part 1: Framework. www.iso.org/standard/83185.html
  3. Tongbiao Zhao*，Qi Zhou*, et al. ISO 18162:2024 Biotechnology — Biobanking — Requirements for human neural stem cells derived from pluripotent stem cells. www.iso.org/standard/85207.html
  4. ISSCR Standard Steering Committee*. Standards for Human Stem Cell Use in Research. ISSCR, www.isscr.org/basic-research-standards