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Name:
 TENG Zhao-Qian
Subject:
 Regenerative Medicine
Tel/Fax:
 +86-10-82619699  / 
E-mail:
 tengzq@ioz.ac.cn; zhaoqian.teng@outlook.com
Address:
 3A Datun Rd, Chaoyang District, Beijing 100101, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, CAS
More:
 Group of Stem Cell and Traumatic Brain Injury      
Resume:

Sep 2014-present, Professor, Institute of Zoology, Chinese Academy of Sciences
2014, Research Associate, Johns Hopkins University School of Medicine, USA
2008-2013, Postdoctoral Fellow, University of New Mexico School of Medicine/Louisiana State University Health Sciences Center, USA
2005- 2007, Postdoctoral Fellow, China Agricultural University
2002-2005, Ph.D. student, Institute of Zoology, Chinese Academy of Sciences

Research Interests:

We study the cellular and molecular mechanisms underlying the pathology of neurodegenerative and neuropsychiatric disorders, including contributions from microglia and risk factors to the pathogenesis, in order to discover potential therapeutic targets and to turn genes and cells into ways to regenerate and repair the brain.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Liu C#, Shao FH#, He XC#, Du HZ, Liu CM*, Zhou B*, Teng ZQ*. Single-Cell RNA Sequencing Uncovers Molecular Features Underlying the Disrupted Neurogenesis Following Traumatic Brain Injury. Glia. 2025, 73(5):1036-1050.
  2. Liu J#, Wang Z#, Liang W, Zhang Z, Deng Y, Chen X, Hou Z, Xie Y, Wang Q, Li Y, Bai C, Li D, Mo F, Wang H, Wang D, Yuan J*, Wang Y*, Teng ZQ*, Hu B*. Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer's disease. Immunity. 2025, 58(7):1830-1846.
  3. Li CP#, Wu S#, Sun YQ, Peng XQ, Gong M, Du HZ, Zhang J, Teng ZQ*, Wang N*, Liu CM*. Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma. Cell Reports Medicine. 2024, 5(5):101554.
  4. Liu C#, Gao X#, Shi RX#, Wang YY, He XC, Du HZ, Hu B, Jiao J, Liu CM, Teng ZQ*. Microglial transglutaminase 2 deficiency causes impaired synaptic remodelling and cognitive deficits in mice. Cell Proliferation. 2023, 56(9):e13439.
  5. Liu PP#, Dai SK#, Mi TW#, Tang GB, Wang Z, Wang H, Du HZ, Tang Y*, Teng ZQ*, Liu CM*. Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Molecular Medicine. 2022, 14(12):e15795.
  6. Wang YY, Deng YS, Dai SK, Mi TW, Li RY, Liu PP, Liu C, He BD, He XC, Du HZ, Yang HC, Tang Y, Liu CM*, Teng ZQ*. Loss of microglial EED impairs synapse density, learning, and memory. Molecular Psychiatry. 2022, 27(7):2999-3009.
  7. Dai SK, Liu PP, Du HZ, Liu X, Xu YJ, Liu C, Wang YY, Teng ZQ*, Liu CM*. Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters. EMBO Reports. 2021, 22 (10): e52023.
  8. Liu C#, Dai SK#, Shi RX, He XC, Wang YY, He BD, Sun XW, Du HZ, Liu CM*, Teng ZQ*. Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration. Glia. 2021, 69 (5): 1292-1306.
  9. Wang ZM, Liu C, Wang YY, Deng YS, He XC, Du HZ, Liu CM*, Teng ZQ*. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell Death Discovery. 2020, 6 (1): 1-11.
  10. Cheng Y#, Wang ZM#, Tan W#, Wang X#, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, Zhou Z, Liu A, Tang GB, Liu C, Dai ZJ, Wang YY, Wang H, Wang X, Kang Y, Lin L, Chen Z, Xie N, Sun Q, Xie W, Peng J, Chen D*, Teng ZQ*, Jin P*. Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nature Neuroscience. 2018, 21(12): 1689-1703.
  11. Chen R#, Zhang J#, Fan N#, Teng ZQ#, Wu Y#, Yang H, Tang YP, Sun H, Song Y, Chen C*. Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell. 2013, 155(5): 1154-1165.
  12. Liu C#, Teng ZQ#, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X*. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. 2010, 6(5): 433-44.