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Name:
 HUANG Shiqiang
Subject:
 Regenerative Medicine
Tel/Fax:
 +86-10-64807768  / 
E-mail:
 huangsq@ioz.ac.cn
Address:
 Institute of Zoology, Chinese Academy of Siences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
 Group of Stem Cell and Regenerative Metabolism      
Resume:

Dr. Shyh-Chang Ng (Shiqiang Huang) is the Principal Investigator of the Stem Cell and Regenerative Metabolism Lab at the Institute of Zoology, Chinese Academy of Sciences, and a full Professor at the University of Chinese Academy of Sciences. He graduated with an A.B. (summa cum laude) from Princeton University, and a Ph.D. from Harvard Medical School. His lab is focused on investigating the nutrition and metabolic programming required for stem cell proliferation, differentiation and regeneration, developing advanced technologies such as spatial metabolomics, and studying multiple tissues such as skeletal muscle and placenta as a basis for the treatment of metabolic diseases such as muscle atrophy, sarcopenic obesity, diabetes, and pre-eclampsia. He is the Associate Editor of Cell Proliferation. He is also a member of the Cell Proliferation editorial board, Institute of Zoology academic advisory council, and the Chinese Gerontology and Geriatrics Society Anti-Aging scientific advisory board. He has published over 60 papers in journals such as Science, Cell, Nature Medicine, Cell Stem Cell, Cell Metabolism, and Cell Research, with more than 11000 citations to date.

Experience:

2005-2008 Princeton University, A.B. (summa cum laude)

2009-2013 Harvard Medical School, Ph.D.

2013-2017 Genome Institute of Singapore, Principal Investigator

2017-present, Institute of Zoology, Principal Investigator

Research Interests:

The research group is dedicated to studying the nutritional and metabolic programming required for stem cell proliferation, differentiation and regeneration processes. Metabolism is the core of maintaining cell growth and function in tissues and organs, and also the main source of energy supply for living systems. The metabolome is directly associated with phenotype and can reflect the physiological or pathological state of the body. As one of the young scholars who pioneered the field of Stem Cell Metabolism, Professor Shyh-Chang Ng led his research team to conduct a series of studies and analyses on stem cell metabolomics, exploring the nutritional and metabolic programming required for stem cell differentiation and regeneration processes.

(1) Constructing tissue models based on spatial metabolomics and 3D muscle models in vitro and in vivo, and upgrading metabolomics analysis of different cell types through the development of metabolomics, artificial intelligence technology, liquid chromatography-mass spectrometry, and mass spectrometry imaging technology, gradually realizing spatial metabolomics and analyzing the spatial metabolic laws of development and regeneration. The analysis revealed the metabolic laws and principles that govern reprogramming, muscle atrophy, muscle regeneration, exercise, pregnancy, and embryonic development. These studies have been highlighted by Nature Medicine, Science, etc. (Nat Med 2016, Genes Dev 2017, Adv Sci 2023, Bioanal Chem 2023, Sci Adv 2023, Trends Endocrin Metab 2024, Cell Stem Cell 2024, Cell 2024)

(2) Study the nutritional and metabolic programming principles required for stem cell regeneration. By combining big data analysis techniques such as gene sequencing and metabolomics, we aim to identify key factors that can regulate tissue regeneration. It was found that stem cell factors such as Lin28 promote tissue development and regeneration through nutrient metabolism rate, epigenetic modification metabolism, and metabolic stress response. The regulation of cell fate through nutritional metabolism is both cause and effect. These studies have been highlighted by Nature, Science, etc. (Cell 2011, Science 2012, Cell 2013, Cell Stem Cell 2013, Trends Endocrin Metab 2016, Cell Prolif 2023, Cell Res 2023)

(3) Based on the above research, devise new solutions for the diagnosis and treatment of metabolic diseases such as muscle atrophy, sarcopenic obesity, diabetes and pre-eclampsia.

Awards and Honors:

2023, Phoenix Plan Leading Talent Program, Chaoyang, Beijing

2022, National Science Award for COVID-19 Anti-Pandemic Team Members

2020, Outstanding Science and Technology Achievement Prize (Team Major Contributor), Chinese Academy of Sciences (CAS)

2019, Innovative Scientist of the Year, CAS

2018, VcanBio Prize for Innovative Breakthroughs in Medicine

2017, Howard Hughes Medical Institute (HHMI) International Scholar

2013, Travel Award, Gordon Conference

2012, Travel Award, International Society for Stem Cell Research (ISSCR)

2011, ISSCR Best Poster Award

Professional Activities:

Cell Proliferation editorial board (2018-)

Cell Proliferation associate editor (2019-)

Institute of Zoology academic advisory council (2020-)

Chinese Gerontology and Geriatrics Society, Anti-Aging scientific advisory board (2021-)

Journal of Cachexia, Sarcopenia and Muscle editorial board and associate editor(2024-)

Research Grants:

Selected Publications:
  1. Yu D, Luo L, Wang H#, Shyh-Chang N#. Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses. Trends Endocrinol Metab. 2024 Aug 8:S1043-2760(24)00192-9. doi: 10.1016/j.tem.2024.07.011. Online ahead of print.
  2. Yu D*, Wan H*, Tong C*, Guang L*, Chen G*, Su J*, Zhang L, Wang Y, Xiao Z, Zhai J, Yan L, Ma W, Liang K, Liu T, Wang Y, Peng Z, Luo L, Yu R, Li W#, Qi H#, Wang H#, Shyh-Chang N#. A multi-tissue metabolome atlas of primate pregnancy. Cell. 2024 Feb 1;187(3):764-781.e14. doi: 10.1016/j.cell.2023.11.043.
  3. Yu X*, Wu H*, Su J*, Liu X, Liang K, Li Q, Yu R, Shao X, Wang H#, Wang YL#, Shyh-Chang N#. Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells. Cell Stem Cell. 2024 Jul 23:S1934-5909(24)00253-4.  doi: 10.1016/j.stem.2024.07.003. Online ahead of print.
  4. Wang P, Liu X, Yao Z, Chen Y, Luo L, Liang K, Tan JE, Chua MJ, Chua YB, Ma S, Zhang L, Ma W, Liu S, Cao W, Guo L, Guang L, Wang Y, Zhao H, Ai N, Li Y, Li C, Wang RR, Teh BT, Jiang L, Yu K, Shyh-Chang N#. Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state. Cell Research. 2023 May 15. doi: 10.1038/s41422-023-00818-y. Online ahead of print.
  5. Wang R, Zhang P#, Wang J, Ma L, E W, Suo S, Jiang M, Li J, Chen H, Sun H, Fei L, Zhou Z, Zhou Y, Chen Y, Zhang W, Wang X, Mei Y, Sun Z, Yu C, Shao J, Fu Y, Xiao Y, Ye F, Fang X, Wu H, Guo Q, Fang X, Li X, Gao X, Wang D, Xu PF, Zeng R, Xu G, Zhu L, Wang L, Qu J, Zhang D, Ouyang H, Huang H, Chen M, Shyh-Chang N#, Liu GH#, Yuan GC#, Guo G#, Han X#. Construction of a cross-species cell landscape at single-cell level. Nucleic Acids Research. 2023 Jan 25;51(2):501-516. doi: 10.1093/nar/gkac633.
  6. Luo L, Chua YB, Liu T, Liang K, Chua MJ, Ma W, Goh JW, Wang Y, Su J, Ho YS, Li CW, Liu KH, Teh BT, Yu K, Shyh-Chang N#. Muscle injuries induce a prostacyclin-PPARγ/PGC1a-FAO spike that boosts regeneration. Advanced Science. 2023 May 4:e2301519. doi: 10.1002/advs.202301519. Online ahead of print.
  7. Ma W, Luo L, Liang K, Liu T, Su J, Wang Y, Li J, Zhou SK, Shyh-Chang N#. XAI-enabled neural network analysis of metabolite spatial distributions. Anal Bioanal Chem. 2023 Jun;415(14):2819-2830. doi: 10.1007/s00216-023-04694-8. Epub 2023 Apr 21.
  8. Luo L, Ma W, Liang K, Wang Y, Su J, Liu R, Liu T, Shyh-Chang N#. Spatial metabolomics reveals skeletal myofiber subtypes. Science Advances. 2023 Feb 3;9(5):eadd0455. doi: 10.1126/sciadv.add0455.
  9. Shyh-Chang N＃ and Lei Li＃. Stabilizing formative pluripotent states with germ cell competency. Cell Stem Cell. 2021 Mar; doi:10.1016/j.stem.2021.02.021.
  10. Jiang Z, Guang L, Li L, Shyh-Chang N#. Putting stem cells on a low-fat diet switches their pluripotent state. Cell Stem Cell. 2019 Jul 3;25(1):3-5.doi: 10.1016/j.stem.2019.06.002.
  11. Liu TM, Shyh-Chang N#. SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nature Cell Biology. 2017 Apr 27;19(5):412-414.doi: 10.1038/ncb3522.
  12. Fukawa, T., Yan-Jiang, B.C., Min-Wen, J.C., Jun-Hao, E.T., Huang, D., Qian, C.N., Ong, P., Li, Z., Mohan, R.E., Wang, R.R., Kanayama, H., Lai, J.H., Chua, C., Ong, H.S., Tan, K.K., Ho, Y.S., Tan, I.B.#, Teh, B.T.#, Shyh-Chang, N#. Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nature Medicine. 2016 Jun;22(6):666-71.doi: 10.1038/nm.4093. Epub 2016 May 2.
  13. Jun-Hao ET, Gupta RR, Shyh-Chang, N#. Lin28 and let-7 in the metabolic physiology of aging. Trends Endocrinol Metab. 2016 Mar;27(3):132-141. doi: 10.1016/j.tem.2015.12.006.
  14. Shyh-Chang, N. and Daley, G. Q. Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Cell Metabolism. 2015 Mar 3;21(3):349-50.doi: 10.1016/j.cmet.2015.02.011.
  15. Shyh-Chang, N.*, Zhu, H.*, de Soysa, T. Y., Shinoda, G., Seligson, M. T., Tsanov, K. T., Nguyen L., Asara, J. M., Cantley, L. C., and Daley, G. Q. Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell. 2013 Nov 7;155(4):778-92.doi: 10.1016/j.cell.2013.09.059.
  16. Shyh-Chang, N. and Daley, G. Q. Lin28: Primal regulator of growth and metabolism in stem cells. Cell Stem Cell. 2013 Apr 4;12(4):395-406.doi: 10.1016/j.stem.2013.03.005.
  17. Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., Asara, J. M., Daley, G. Q., and Cantley, L. C. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science. 2012 Nov 1; 339(6116):222-6.doi: 10.1126/science.1226603.
  18. Zhang, W. C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B. S., Sun, L. L., Tai, B. C., Nga, M. E., Bhakoo, K. K., Jayapal, S. R., Nichane, M., Yu, Q., Ahmed, D. A., Tan, C., Sing, W. P., Tam, J., Thirugananam, A., Noghabi, M. S., Pang, Y. H., Ang, H. S., Mitchell, W., Robson, P., Kaldis, P., Soo, R. A., Swarup, S., Lim, E. H., and Lim, B. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell. 2012 Jan 20;148(1-2):259-72.doi: 10.1016/j.cell.2011.11.050. Epub 2012 Jan 5.
  19. Zhu, H.*, Shyh-Chang, N.*, Segre, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J. P., Kharas, M. G., Urbach, A., Thornton, J. E., Triboulet, R., Gregory, R. I., DIAGRAM Consortium, MAGIC Investigators, Altshuler, D., and Daley GQ. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011 Sep 30;147(1):81-94. doi: 10.1016/j.cell.2011.08.033.
  20. Zhu, H., Shah, S., Shyh-Chang, N., Shinoda, G., Einhorn, W. S., Viswanathan, S. R., Takeuchi, A., Grasemann, C., Rinn, J. L., Lopez, M. F., Hirschhorn, J. N., Palmert, M. R., and Daley, G. Q. Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nature Genetics. 2010 Jul;42(7):626-30. doi: 10.1038/ng.593. Epub 2010 May 30.