Research Interests:

1. Decoding the genetic and epigenetic mechanisms of human aging Combining primate models, stem cells, gene-editing techniques, genome-wide screening, single-cell sequencing, multi-omics analyses and artificial intelligence, we aim to study the genetic and epigenetic basis of human aging and aging-related diseases and explore new strategies for delaying aging (e.g. brain aging and cardiovascular aging) and for the prevention and treatment of aging-related diseases (e.g. neurodegenerative diseases and atherosclerosis) so as to achieve the goal of healthy aging. 2. Stem cell-based disease mechanism research and precision medicine on human diseases Using patient-derived induced pluripotent stem cells (iPSC) and diseased embryonic stem cells (ESC) created in vitro, combined with directed differentiation and transplantation technologies, we aim to study molecular mechanisms and new targets of human diseases at the genome level, develop stem cell-based drug screening and evaluation systems, evaluate lead compounds that target specific targets of human diseases, and advance clinical translation of stem cell and aging-related technologies. 3. Development and application of new gene-editing methods and gene therapy technologies On the basis of HDAdV, telHDAdV, TTALE and CRISPR/Cas9 techniques, we aim to develop new methods to safely and efficiently edit the human genome and establish new de-senescence and pro-regenerative strategies via the applications of stem cells and new strategies for gene therapy, thus providing scientific basis for gene repair in rare diseases, genetic enhancement of human stem cells, and intervention of aging-related diseases.

Awards and Honors:

2024, Chief scientist of Basic Science Center Program of NSFC 2024, Prize for Scientific and Technological Innovation of the Ho Leung Ho Lee Foundation 2024, Outstanding Contribution Scientist in Stem Cell Research 2023, Fellow of the International Union of Physiological Sciences (IUPS) Academy 2023, National Innovation Pioneer Medal 2023, Top 10 Science Advances in China 2023, Top 10 Scientific Advances in Life Sciences of China 2023, China Annuel Medical Innovation 2023, Most Cited Chinese Researchers (ELSEVIER) 2023, Second-class Beijing Science and Technology Award (first place) 2022, Fellow of the Academic Advisory Committee of the Chinese Academy of Medical Sciences 2022, Outstanding scientific, technological, and managerial talents with significant contributions in Beijing 2022, Most Cited Chinese Researchers (ELSEVIER) 2022, First prize for the Overseas Chinese Contribution Award 2022, China Medical Science and Technology Award 2021, XPLORER PRIZE 2021, Most Cited Chinese Researchers (ELSEVIER) 2021, Beijing Outstanding Youth Zhongguancun Award 2021, Most Picked Paper Award 2020 (Chinese Scientists with Cell Press) 2020, Most Cited Chinese Researchers (ELSEVIER) 2020, Top 10 Science Advances in China 2020, Top 10 Scientific Advances in Life Sciences of China 2020, Outstanding Science and Technology Achievement Prize of the Chinese Academy of Sciences 2020, Chief Scientist of National Key R&D Program 2019, China Youth Science and Technology Award (special prize) 2019, Chief scientist of Science Fund for Creative Research Groups of NSFC 2019, Gu Xiaocheng Lecture Award 2019, Stem Cell Research Innovation Award 2019, The VCANBIO Award for Innovation and Breakthroughs in Life Sciences and Medicine 2019, Wuxi AppTec Life Science and Chemistry Awards 2019, Promega Innovation Award 2018, Tan Jiazhen Prize in Life Sciences Innovation 2018, Top 10 Scientific Advances in Life Sciences of China 2017, Beijing Science and Technology Award 2017, Shulan Medical Youth Award 2017, Youth Scientist of Chinese Academy of Sciences 2017, CSCB Young Investigator 2017, Gerontology Outstanding Contribution Award 2016, Innovative Award of “the Capital of Ten Scientific and Technological Research and Management Plan” 2016, National Science Fund for Distinguished Young Scholars 2015, Chief scientist of the National Key Basic Research Program of China 2015, Bill and Melinda Gates Foundation Grand Challenges-Young Scientist 2015, CSSCR Stem Cell Young Investigator Award 2013, Bei Shi-Zhang Young Scientist Award in Biophysics 2012, National Science Fund for Excellent Young Scholars Editorial board 2022-present, Editorial board, Science China-Life Sciences (Impact factor 8.0) 2022-present, Associate editor, Research (Impact factor 8.5) 2022-present, Editor-in-Chief, Life Medicine   2022-present, Editorial board, Bone Research (Impact factor 14.3) 2022-present, Editorial board, PLOS Biology (Impact factor 7.8) 2021-present, Associate Editor, National Science Open 2021-present, Senior Editor, Current Medicine 2019-present, Editorial board, Cell Reports (Impact factor 7.5) 2019-present, Editorial board, Aging Cell (Impact factor 8.0) 2019-present, Editorial board, Cell Regeneration (Impact factor 4.0) 2017-present, Editorial board, Cell Stress (Impact factor 4.1) 2017-present, Editorial board, Life Science Alliance (Impact factor 3.3) 2015-present, Deputy Editor-in-Chief, Protein & Cell (Impact factor 13.6) Scientific committee/board 2022, Convenor, Aging Biomarker Consortium, China (ABC) 2022, Director, Academic Committee of Beijing Institute for Stem Cell and Regenerative Medicine 2021, Vice Director, Beijing Institute for Stem Cell and Regenerative Medicine 2020, Vice Director, Academic Committee of Institute of Zoology, CAS 2019, Founder & Council Member of Academy for Health & Lifespan Research (AHLR) 2019, Vice Director, Beijing Institute for Stem Cell and Regenerative Medicine 2019, Vice Director, Institute for Stem Cell and Regeneration, CAS 2019, Vice Director, State Key Laboratory of Membrane Biology 2019, President, Committee of Antiaging, China Association of Gerontology and Geriatrics 2018, President, Chinese Society of Aging Cell Research (CSACR) 2017, Vice president, Chinese Society of Aging Biology (CSAB)

Professional Activities:

Research Grants:

Selected Publications:

Zhao Q, Jing Y, Jiang X, Zhang X, Liu F, Huang H, Zhang Z, Wang H, Sun S, Ma S, Zhang W, Yu Y, Fu X, Zhao G, Qu J*, Wang S*, Liu GH*. SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1. Nature Metabolism. 2025. 7(3):556-573. Li Y, Huang Z, Xu L, Fan Y, Ping J, Li G, Chen Y, Yu C, Wang Q, Song T, Lin T, Liu M, Xu Y, Ai N, Meng X, Qiao Q, Ji H, Qin Z, Jin S, Jiang N, Wang M, Shu S*, Zhang F*, Zhang W*, Liu GH*, Chen L*, Jiang L*. UDA-seq: universal droplet microfluidics-based combinatorial indexing for massive-scale multimodal single-cell sequencing. Nature Methods. 2025. doi: 10.1038/s41592-024-02586-y. Li H, Zhao W, Yang F, Qiao Q, Ma S, Yang K, Song S, Wang S, Qu J*, Liu GH*, Bao Y*, Zhang W*. Immunosenescence Inventory-a multi-omics database for immune aging research. Nucleic Acids Research. 2025. 53(D1):D1047-D1054. Yang Y, Lu X, Liu N, Ma S, Zhang H, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M, Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, Li J, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhu G, Song W, Horvath S, Esteban CR, Song M, Wang S, Zhao G, Li W, Izpisua Belmonte JC, Qu J*, Zhang W*, Liu GH*. Metformin Decelerates Aging Clock in Male Monkeys. Cell. 2024.187(22):6358-6378. Ma S, Ji Z, Zhang B, Geng L, Cai Y, Nie C, Li J, Zuo Y, Sun Y, Xu G, Liu B, Ai J, Liu F, Zhao L, Zhang J, Zhang H, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X, Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Esteban CR, Liu Z, Deng H, Wen F, Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Belmonte JCI, Qu J*, Zhang W*, Gu Y*, Liu GH*. Spatial Transcriptomic Landscape Unveils Immunoglobin-associated Senescence as a Hallmark of Aging. Cell. 2024.187(24):7025-7044. Li HY, Wang M, Jiang X, Jing Y, Wu Z, He Y, Yan K, Sun S, Ma S, Wang S, Belmonte JCB, Qu J*, Zhang W*, Wei T*, Liu GH*. CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver. Nucleic Acids Research. 2024.52(19):11481-11499. Wang Q, Wang X, Liu B, Ma S, Zhang F, Sun S, Jing Y, Fan Y, Ding Y, Xiong M, Li J, Zhai Q, Zheng Y, Liu C, Xu G, Yang J, Wang S, Ye J, Belmonte JCI, Qu J*, Liu GH*, Zhang W*. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland. Nature Aging. 2024. 4(3):396-413. Bi S, Jiang X, Ji Q, Wang Z, Ren J, Wang S, Yu Y, Wang R, Liu Z, Liu J, Hu J, Sun Q, Wu Z, Diao Z, Li J, Sun L, Belmonte JCI, Zhang W*, Liu GH*, Qu J*. The Sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA. Developmental Cell. 2024. 59(8):991-1009. Yang S, Liu C, Jiang M, Liu X, Geng L, Zhang Y, Sun S, Wang K, Yin J, Ma S, Wang S, Izpisua Belmonte JC, Zhang W*, Qu J*, Liu GH*. A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Protein Cell. 2024. 15(2):98-120. (Cover story) Sun S, Li J, Wang S, Li J, Ren J, Bao Z, Sun L, Ma X, Zheng F, Ma S, Sun L, Wang M, Yu Y, Ma M, Wang Q, Chen Z, Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ, Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. CHIT1-positive microglia drive motor neuron aging in the primate spinal cord. Nature. 2023. 624(7992):611-620. Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C,  Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 2023. 186(2):287-304. Cai Y, Xiong M, Xin Z, Liu C, Jie R，Yang X, Lei J, Li W, Liu F, Chu Q, Yin J, Ye Y, Liu D, Fan Y, Sun S, Zhao Q, Zhao L, Che S, Zheng Y, Yan H, Ma S, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Decoding aging-dependent regenerative decline across tissues at single-cell resolution. Cell Stem Cell. 2023. 30(12):1674-1691. Ye Y, Yang K, Liu H, Yu Y, Song M, Huang D, Lei J, Zhang Y, Liu Z, Chu Q, Fan Y, Zhang S, Jing Y, Esteban CR, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B. Nature Aging. 2023. 3(10):1269-1287. (Cover story) Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, Jing Y, Zhang S, Zhao Q, Li H, Yu Z, Liu Z, Bi S, Wei T, Yang Y, Xiao J, Belmonte JCI, Qu J*, Zhang W*, Ci W*, Liu GH*. M6A epitranscriptomic regulation of tissue homeostasis during primate aging. Nature Aging. 2023. 3(6):705-721. (Cover story) Li J, Xiong M, Fu XH, Fan Y, Dong C, Sun X, Zheng F, Wang SW, Liu L, Xu M, Wang C, Ping J, Che S, Wang Q, Yang K, Zuo Y, Lu X, Zheng Z, Lan T, Wang S, Ma S, Sun S, Zhang B, Chen CS, Cheng KY, Ye J, Qu J, Xue Y, Yang YG*, Zhang F*, Zhang W*, Liu GH*. Determining a Multimodal Aging Clock in a Cohort of Chinese Women. Med. 2023. 4(11):825-848. (Cover story) Cheng F, Ji Q, Wang L, Wang CC, Liu GH*, Wang L*. Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H2O2 release. EMBO Reports. 2023. 24(8):e56439. (Cover story) Wang C, Yang K, Liu X, Wang S, Song M, Belmonte JC, Qu J*, Liu GH*, Zhang W*. MAVS antagonizes human stem cell senescence as a mitochondrial stabilizer. Research. 2023. 6:0192. Jing Y, Zuo Y, Sun L, Yu ZR, Ma S, Hu H, Zhao Q, Huang D, Zhang W, Belmonte JCI, Yu Y*, Qu J*, Liu GH*, Wang S*. SESN1 is a FOXO3 effector that counteracts skeletal muscle aging in primates. Cell Proliferation. 2023. 56(5):e13455. Ma S, Wang S, Ye Y, Ren J, Chen R, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Heterochronic parabiosis induces systemic rejuvenation and stem cell revitalization across aged tissues. Cell Stem Cell. 2022. 29(6):990-1005. Liu Z, Ji Q, Ren J, Yan P, Wu Z, Wang S, Sun L, Wang Z, Li J, Sun G, Liang C, Sun R, Jiang X, Hu J, Ding Y, Wang Q, Bi S, Wei G, Cao G, Zhao G, Wang H, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes that Drive Cellular Aging. Developmental Cell. 2022. 57(11):1347-1368. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing heterochromatin by APOE mediates senescence. Nature Aging. 2022. 2(4):303-316. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, Wang Z, Chen H, Xia K, Lai X, Wang Q, Yang K, Li W, Wu Z, Wang C, Yan H, Jiang X, Ji Z, Ma M, Long X, Wang S, Wang H, Sun H, Belmonte JCI, Qu J*, Xiang AP*, Liu GH*. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Research. 2022. 50(6):3323-3347. Kang W, Jin T, Zhang T, Ma S, Yan H, Liu Z, Ji Z, Cai Y, Wang S, Song M, Ren J, Hu B, Zhou Q, Zhang W*, Qu J*, Bao Y*, Liu GH*. Regeneration Roadmap: database resources for regenerative biology. Nucleic Acids Research. 2022. 50(D1):D1085-D1090. Yan H, Wang R, Ma S, Huang D, Wang S, Ren J, Lu C, Chen X, Zhang W*, Qu J*, Zhou Y*, Liu GH*. Lineage Landscape: A comprehensive database that records lineage commitment across species. Nucleic Acids Research. 2022. 51(D1):D1061-D1066. Liu ZP, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JD, Hernandez-Benitez R, Shyh-Chang Ng, Izpisua Belmonte JC, Zhang WQ*, Qu J*, Liu GH*. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discovery. 2022. 1;8(1):6. Hishida T, Yamamoto M, Hishida-Nozaki Y, Shao C, Huang L, Wang C, Shojima K, Xue Y, Hang Y, Shokhirev M, Memczak S, Sahu SK, Hatanaka F, Ros RR, Maxwell MB, Chavez J, Shao Y, Liao HK, Martinez-Redondo P, Guillen-Guillen I, Hernandez-Benitez R, Esteban CR, Qu J, Holmes MC, Yi F, Hickey RD, Garcia PG, Delicado EN, Castells A, Campistol JM, Yu Y, Hargreaves DC, Asai A, Reddy P, Liu GH, Izpisua Belmonte JC. In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell Reports. 2022. 39(4):110730. Wang W, Zheng Y, Sun S, Li W, Song M, Ji Q, Wu Z, Liu Z, Fan Y, Liu F, Li J, Esteban CR, Wang S, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Tang F*, Liu GH*. A Genome-wide CRISPR-Based Screen Identifies KAT7 as a Senescence Driver. Science Translational Medicine. 2021.13, Jan 6;13(575):eabd2655. Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S, Wang S, He Y, Esteban CR, Huang J, Yu N, Chan P, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of human skin aging. Developmental Cell. 2021. 56(3):383-397 (Cover story) Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W*, Qu J*, Liu GH*. Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2021. 31(2):187-205. Wang S, Yao X, Ma S, Ping Y, Fan Y, Sun S, He Z, Shi Y, Sun L, Xiao S, Song M, Cai J, Li J, Tang R, Zhao L, Wang C, Wang Q, Zhao L, Hu H, Liu X, Sun G, Chen L, Pan G, Chen H, Li Q, Zhang P, Xu Y, Feng H, Zhao GG, Wen T, Yang Y, Huang X, Li W, Liu Z, Wang H, Wu H, Hu B, Ren Y, Zhou Q, Qu J*, Zhang W*, Liu GH*, Bian XW*. A Single-cell Transcriptomic Landscape of the Human COVID-19 Lung. Nature Cell Biology. 2021. 23(12):1314-1328 (Leading contact) Zhang H, Li J, Ren J, Sun S, Ma S, Zhang W, Yu Y, Cai Y, Yan K, Li W, Hu B, Chan P, Zhao GG, Belmonte JC, Zhou Q, Qu J*, Wang S*, Liu GH*. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein Cell. 2021. 12(9):695-716. (Cover story) Aging Atlas Consortium, Zhang W*, Jing Qu*, Bao Y*, Liu GH*. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Research. 2021. 8;49(D1):D825-D830. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC*, Jing Qu*, Tang F*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180(3):585-600. (Cover story) Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC*, Zhang W*, Qu J*, Liu GH*. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020. 180(5):984-1001. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research. 2020. 10;1-18. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W*, Sun Q*, Qu J*, Liu GH*. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870 Wang F, Zhang W, Yang Q, Kang Y, Fan Y, Wei J, Liu Z, Dai S, Li H, Li Z, Xu L, Chu C, Qu J, Si C, Ji W*, Liu GH*, Long C*, Niu Y*. Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing. Protein Cell. 2020. 11(11):809-824. (Cover story) Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J*, Tang F*, Liu GH*. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell. 2019. 24(3), 447-461. (Cover story) Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Belmonte J, Chan P, Qu J*, Liu GH*. Stabilizing Heterochromatin by DGCR8 Alleviates Senescence and Osteoarthritis. Nature Communications. 2019.10(1):3329. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J*, Tang F*, Liu GH*. Upregulation of FOXD1 by YAP Alleviates Senescence and Osteoarthritis. PLoS Biology. 2019. 17(4):e3000201. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J*, Tang F*, Liu GH*. Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Cell Reports. 2019. 26(13):3643-3656. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6 Deficiency Results in Developmental Retardation in Cynomolgus Monkeys. Nature. 2018. 560(7720):661-665 (Leading contact) Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J*, Tang F*, Liu GH*. ATF6 Safeguards Organelle Homeostasis and Cellular Aging in Human Mesenchymal Stem Cells. Cell Discovery. 2018. Jan 5;4:2.  Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu GH*, Wang L*. Metformin Alleviates Human Cellular Aging by Upregulating the ER Peroxidase GPx7. Aging Cell. 2018.17(4):e12765. Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J*, Suzuki K*, Belmonte JC*, Liu GH*. Differential Stem Cell Aging Kinetics in Hutchinson–Gilford Progeria Syndrome and Werner Syndrome. Protein Cell. 2018. 9(4):333-350. (Cover story) Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T*, Qu J*, Liu GH*. Visualization of Aging-associated Chromatin Alterations with an Engineered TALE System. Cell Research. 2017. 27(4):483-504. (Cover story) Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y*, Qu J*, Liu GH*. CRISPR/Cas9-Mediated Targeted Gene Correction in Amyotrophic Lateral Sclerosis Patient iPSCs. Protein Cell. 2017. 8(5):365-378. (Cover story)  Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH*, Misteli T*, Repression of the Antioxidant NRF2 Pathway in Premature Aging. Cell. 2016. 165(6):1361-1374. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J*, Tang F*, Liu GH*. SIRT6 Safeguards Human Mesenchymal Stem Cells from Oxidative Stress by Coactivating NRF2. Cell Research. 2016. 26(2):190-205. Reviews or Views ： Exploring the heterogeneous targets of metabolic aging at single-cell resolution. Trends in Endocrinology & Metabolism. 2025. 36(2):133-146. (Cover story) Insights and Interventions in Age-Associated Inflammation. Current Opinion in Genetics and Development. 2025. 91:102306. Metabolic heterogeneity in humans. Cell. 2024. 187(15):3821-3823. (Leading Edge Voices) Roles of chromatin and genomic instabilities in cellular senescence and their relevance to ageing and related diseases. Nature Reviews Molecular Cell Biology. 2024. 25(12):979-1000. Stress, epigenetics, and aging: unraveling the intricate crosstalk. Molecular Cell. 2024. 84(1):34-54. Perspectives on biomarkers of reproductive aging for fertility and beyond. Nature Aging. 2024. 4(12):1697-1710. Targeting aging and age-related diseases with vaccines. Nature Aging. 2024. 4(4):464-482. Emerging epigenetic insights into aging mechanisms and interventions. Trends in Pharmacological Sciences. 2024. 45(2):157-172. Multimodal omics approaches to aging and age-related diseases. Phenomics. 2024. 4(1):56-71. The Aging Biomarker Consortium represents a new era for aging research in China. Nature Medicine. 2023. 29(9):2162-2165. Endogenous retroviruses in development and health. Trends in Microbiology. 2023. 32(4):342-354. Acting on ethics and governance of aging research. Trends in Molecular Medicine. 2023. 29(6):419-421. Decoding Aging Hallmarks at the Single-Cell Level. Annual Review of Biomedical Data Science. 2023. 10:6:129-152. Biomarkers of aging. Science China Life Science. 2023. 66(5):893-1066. (Cover story) Q&A with Guang-Hui Liu. Cell Reports. 2023. 42(8):112862. Deciphering RNA m6A regulation in aging: Perspectives on current advances and future directions. Aging Cell. 2023. 22(10):e13972. A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine. 2023. 2(3): lnad017  Hepatocyte reprogramming in liver regeneration: biological mechanisms and applications. The FEBS Journal. 2023. 290(24):5674-5688. Glutathione restoration: a sword to combat skeletal muscle stem cell aging. Life Metabolism. 2023. 2(3):load012. A narrative review of organoids for investigating organ aging: opportunities and challenges. Journal of Bio-X Research. 2023. 6(1):p 3-14. (Cover story) Fecal microbiota transplantation: a new strategy to delay aging. hLife. 2023. 1(1):8-11. Longevity secret - a pluripotent superpower. Cell Metabolism. 2022. 34(6):803-804. Voicing the story behind the cover. Developmental Cell. 2022. 57(24):2679-2682. A Stem Cell Aging Framework, from Mechanisms to Interventions. Cell Reports. 2022. 41(3):111451. The landscape of aging. Science China Life Science. 2022. 2:1-101. Opening up the black box of human cell plasticity. Innovation. 2022. 3(5):100276. Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal Transduction and Targeted Therapy. 2022. 7(1):374. Genetic Enhancement: an Avenue to Combat Aging-related Diseases. Life Medicine. 2022. 1(3): 307–318. Emerging role of RNA m6A modification in aging regulation. Current Medicine. 2022. 1(8). Potential Approaches for Intervening Aging. National Science Open. 2022. 1(2): 20220021. Deciphering aging at three-dimensional genomic resolution. Cell Insight. 2022. 1(3):100034. Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors. Stem Cells Translational Medicine.2022. 11(3):231-238. Mitochondrial sirtuins, metabolism, and aging. J Genet Genomics. 2022. 49(4):287-298. The Aging Epigenome and its Rejuvenation. Nature Reviews Molecular Cell Biology. 2020. 21(3):137-150. Engineering Tissues and Organs: The Road to the Clinic. Cell. 2020. 181(1):22-23. (Leading Edge Voices) Single-Cell “OMICS” in Aging: A Young Growing Field. Nature Metabolism. 2020. 2(4): 293-302. A Beta-Galactosidase Kiss of Death for Senescent Cells. Cell Research. 2020. 30(7):556-557. Treating Osteoarthritis via Gene Therapy with Rejuvenation Factors. Gene Therapy. 2020. 27(7-8):309-311.  Protein Quality Control of Cell Stemness. Cell Regeneration. 2020. 12;9(1):22. Age-Related Cardiopathies Gene Editing. Aging. 2019. 11(5):1327-1328. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018. 123(7):773-786. Regulation of Stem Cell Aging by Metabolism and Epigenetic Factors. Cell Metabolism. 2017. 26(3):460-474.