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Name:
 Yang Li
Subject:
 Microbiology/Genomics/Immunity
Tel/Fax:
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E-mail:
 yli@ioz.ac.cn
Address:
 Key Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R. China
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Resume:

1997-2001 B.S. Biology, Sichuan University, Chengdu, Sichuan, China

2001-2006 Ph.D. Microbiology, Wuhan University, Wuhan, Hubei, China

2006-2009 Postdoctoral Fellow, Saskatchewan University, Canada

2009-2012 Postdoctoral Fellow, University of California, Riverside, USA

2012-2015 Assistant project scientist, University of California, Riverside, USA

2015-2021 Professor, Fudan University, Shanghai, China

2021/-present, Professor, Principal Investigator, Institute of Zoology, Chinese Academy of Sciences

Research Interests:

The research of my laboratory is focused on RNA viruses and the basic aspects of RNA virology, including virus and host interaction, cell-mediated immune response and virus interaction with RNA interference (RNAi)-directed antiviral innate immunity. My research is primarily dedicated to investigate the role and mechanism of antiviral RNA interference (RNAi) in mammals.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Yunpeng Dai, Binbin Wang, Jiaxin Wang, Xiaocui Wei, Xing Liu, Xu Che, Junxia Li, Wei Lun NG, Lin-Fa Wang, Yang Li *. Increased viral tolerance mediates by antiviral RNA interference in bat cells. Cell Reports, (2024), 43(8)
  2. Guangping Huang, Xing Liu, Xin Huang, Chuang Gao, Zhilin Wang, Junxia Li, Xiaocui Wei, Wen-Hua Yu, Yi Wu, Ying Liu, Jiang Feng, Yang Li *, Fuwen Wei *. Adaptive evolution of traits for parasitism and pathogen transmission potential in bat flies. National Science Review, (2024): nwae245.
  3. Jiaxin Wang, Yang Li *. Current advances in antiviral RNA interference in mammals. The FEBS Journal, (2023), 291(2): 208-216. (Invited review, State-of-the-Art Review)
  4. Yuqiang Zhang, Yunpeng Dai, Jiaxin Wang, Yan Xu, Zhe Li, Jinfeng Lu, Yongfen Xu, Jin Zhong, Shou-Wei Ding*, Yang Li*. Mouse circulating extracellular vesicles contain virus-derived siRNAs active in antiviral immunity. The EMBO Journal, (2022): e109902.
  5. Yan Xu, Zhengwei Zhong, Yanxin Ren, Liting Ma, Zhi Ye, Chuang Gao, Jingwen Wang*, Yang Li*. Antiviral RNA interference in disease vector (Asian longhorned) ticks. PLoS Pathogens, (2021) 17(12): e1010119
  6. Yuqiang Zhang , Yan Xu , Yunpeng Dai, Zhe Li, Jiaxing Wang, Zhi Ye, Yanxin Ren, Hua Wang, Wan-xiang Li, Jinfeng Lu* , Shou-Wei Ding *, Yang Li *. Efficient Dicer processing of virus-derived double-stranded RNAs and its modulation by RIG-I-like receptor LGP2. PLoS Pathogens, (2021) 17(8):e1009790
  7. Yuqiang Zhang, Zhe Li, Zhi Ye, Yan Xu, Binbin Wang, Congcong Wang, Yunpeng Dai, Jinfeng Lu, Boxun Lu, Wanju Zhang *, Yang Li *. The Activation of Antiviral RNA Interference Not Only Exist in Neural Progenitor Cells But Also in Somatic Cells in Mammals. Emerging Microbes & Infections, (2020) 9:1580.
  8. Zhongxin Guo, Yang Li, Shou-Wei Ding﹡. Small RNA-based Antimicrobial Immunity. Nature Reviews Immunology. (2019) 19:31–44
  9. Yang Li, Megha Basavappa, Jinfeng Lu, Shuwei Dong, D. Alexander Cronkite, John T. Prior, Hans-Christian Reinecker, Paul Hertzog, Yanhong Han, Wan-Xiang Li, Sihem Cheloufi, Fedor V. Karginov, Shou-Wei Ding, Kate L. Jeffrey. Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells. Nature Microbiology, (2017) 2: 16250
  10. Yang Li, Jinfeng Lu, Yanhong Han, Xiaoxu Fan, Shou-Wei Ding. RNA interference functions as an antiviral immunity mechanism in mammals. Science, (2013) 342, 6155：231-234