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Name:
 WANG Zhenbo
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807050  / 
E-mail:
 wangzb@ioz.ac.cn
Address:
 The State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
      
Resume:

Ph.D. in developmental biology, Institute of Zoology, Chinese Academy of Sciences  (2004-2010);
Post-doc, Institute of Zoology, Chinese Academy of Sciences (2010-2012);
Associate Professor, Institute of Zoology, Chinese Academy of Sciences（2013-2016）
Professor, Institute of Zoology, Chinese Academy of Sciences（Since 2017）

Research Interests:

Mechanisms of Folliculogenesis, oocyte maturation and fertilization

Awards and Honors:

Outstanding scientific achievement award of National population and Family Planning Commission．

Professional Activities:

Research Grants:

Grants for Young Scientists from National Natural Science Foundation of China.

Selected Publications:
  1. Guo JN, Zhu L, Meng TG, Zhang YN, Sun SM, Yang XM, Zhao BW, Lu YK, Xu YH, Yue W, Han Z, Wong CCL#, Wang ZB#. Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like "band-tightening spell".Cell Mol Life Sci. 2025 Jul 30; 82(1):292.
  2. Zhao BW, Zhang YN, Meng TG, Xu YH, Lu YK, Sun SM, Guo JN, Yang XM, Wang ZB#. Re-establishment of H3K9me2 eliminates the transcriptional inhibition of ST18 on meiotic genes and orchestrates female germ cell development.Nucleic Acids Res. 2025 Jul 8; 53 (13): gkaf657.
  3. Sun SM, Zhao BW, Li YY, Liu HY, Xu YH, Yang XM, Guo JN, Ouyang YC, Weng CJ#, Guan YC#, Sun QY#, Wang ZB#. Loss of UBE2S causes meiosis I arrest with normal spindle assembly checkpoint dynamics in mouse oocytes. Development. 2024 Mar 15; 151(6): dev 202285. 
  4. Wang L, Liu C, Li L, Wei H, Wei W, Zhou Q, Chen Y, Meng TG, Jiao R, Wang ZB#, Sun QY#, Li W#. RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles. Adv Sci (Weinh). 2024 Jan 19:e2306986.
  5. Liu SL, Zuo HY, Zhao BW, Guo JN, Liu WB, Lei WL, Li YY, Ouyang YC, Hou Y, Han ZM, Wang WZ#, Sun QY, # Wang ZB#. A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human. iScience. 2023 Sep 4;26(10):107828.
  6. Meng TG, Guo JN, Zhu L, Yin Y, Wang F, Han ZM, Lei L, Ma XS, Xue Y, Yue W, Nie XQ, Zhao ZH, Zhang HY, Sun SM, Ouyang YC, Hou Y, Schatten H, Ju Z, Ou XH#, Wang ZB#, Wong CC#L, Li Z#, Sun QY#. NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. Adv Sci (Weinh). 2023 Sep; 10(27):e2301940.
  7. Liu W, Lu X, Zhao ZH, Su R, Li QL, Xue Y, Gao Z, Sun SS, Lei WL, Li L, An G, Liu H, Han Z, Ouyang YC, Hou Y, Wang ZB#, Sun QY#, Liu J#.SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing. Elife. 2022 Nov 10;11:e78211.
  8. Meng TG, Lei WL, Lu X, Liu XY, Ma XS, Nie XQ, Zhao ZH, Li QN, Huang L, Hou Y, Ouyang YC, Li L, Tang TS, Schatten H, Xie W, Gao SR, Ou XH#, Wang ZB#, Sun QY#. Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis. Int J Biol Sci. 2022 Jul 11;18(11):4513-4531.
  9. Zhu FY, Wang LL, Meng TG, Wang RL, Yang ZX, Cao Y, Zhu GY, Jin Z, Gao LL , Zeng WT, Wang ZB#, Sun QY#, Zhang D#. Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice. Nat Aging. 2021 Nov;1(11):1010-1023.
  10. Lei WL, Li YY, Meng TG, Ning Y, Sun SM, Zhang CH, Gui Y, Wang ZB#, Qian WP#, Sun QY#. Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis. Cell Death Dis. 2021 Sep 27;12(10):883.
  11. Zhao BW, Sun SM, Xu K, Li YY, Lei WL, Li L, Liu SL, Ouyang YC, Sun QY#, Wang ZB#. FBXO34 Regulates the G2/M Transition and Anaphase Entry in Meiotic Oocytes. Front Cell Dev Biol. 2021 Mar 25;9:647103. 
  12. Meng TG, Zhou Q, Ma XS, Liu XY, Meng QR, Huang XJ, Liu HL, Lei WL, Zhao ZH, Ouyang YC, Hou Y, Schatten H, Ou XH#, Wang ZB#, Gao SR#, Sun QY#. PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.Nat Commun. 2020 Dec 11;11(1):6354.
  13. Lei WL, Han F, Hu MW, Liang QX, Meng TG, Zhou Q, Ouyang YC, Hou Y, Schatten H, Wang ZB#, Sun QY#. Protein phosphatase 6 is a key factor regulating spermatogenesis.  Cell Death Differ. 2020 Jun;27(6):1952-1964.