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Name:
 Moshi Song
Subject:
 Pathology and Pathophysiology
Tel/Fax:
 +86-10-64807079  / 
E-mail:
 songmoshi@ioz.ac.cn
Address:
 State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
 Group of Mitochondrial Disease      
Resume:

Prof. Moshi Song is a principal investigator in the Institute of Zoology of the Chinese Academy of Sciences. Prof. Song got her master’s degree at Karolinska Institute (Sweden) and her Ph.D. at Washington University in St. Louis (USA), received her postdoctoral training at Stanford University (USA), and joined the Institute of Zoology as the leader of the Group of Mitochondrial Disease in 2018. Prof. Song has been focusing on the study of mitochondrial regulation of cardiac aging and related diseases and has published 44 papers in SCI journals including Cell, Cell Research (x2), Advanced Science (x2), Nature Communications (x2), Nature Aging (x2), Nucleic Acids Research (x2) during the last five years. Her major findings are as follows: 1) Elucidation of molecular mechanisms of cardiac aging; 2) Uncover of new biomarkers of cardiac aging; 3) Establishment of interventive strategies for cardiac aging and related diseases.

Research Interests:

Cardiac aging and related diseases

Awards and Honors:

Professional Activities:

Secretary General of Chinese Society for Aging Cell Research in Chinese Society for Cell Biology.

Deputy Director-General of Conmmittee of Antiaging in Chinese association of Gerontology and Geriatrics.

Council member of Chinese Society for Cell Biology.

Council member of China Zoological Society.

Committee member of Academic Subgroup of Free Radical Biology and Free Radical Medicine in the Biophysical Society of China.

Committee member of Mitochondrial Biology Academic Subgroup in the Biophysical Society of China.

Editorial board member of Life Medicine.

Editorial board member of Translational Medicine of Aging.

Research Grants:

Selected Publications:
  1. Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J*, Song M*.Prophylactic supplementation with Lactobacillus reuteri or its metabolite GABA protects against acute ischemic cardiac injury.Adv Sci. 2024.
  2. He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH*, Wang S*, Song M*, Qu J*. 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. Protein Cell. 2023 Apr 13;14(3):202-216.
  3. Aging Biomarker Consortium, Zhang W, Che Y, Tang X, Chen S, Song M*, Wang L*, Sun A*, Chen H*, Xu M*, Wang M*, Pu J*, Li Z*, Xiao J*, Cao C*, Zhang Y*, Lu Y*, Zhao Y*, Wang Y*, Zhang C*, Shen T*, Zhang W*, Tao L*, Qu J*, Tang Y*, Liu GH*, Pei G*, Li J*, Cao F*. A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement, Life Medicine, Volume 2, Issue 5, October 2023, lnad035.
  4. Ren J#, Song M#, Zhang W#, Cai JP, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Chen XC, Ci W, Ding BS, Ding Q, Gao F, Gao S, Han JJ, He QY, Huang K, Ju Z, Kong QP, Li J, Li J, Li J, Li X, Liu B, Liu F, Liu JP, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren R, Song W, Songyang Z, Sun L, Sun YE, Sun Y, Tian M, Tian XL, Tian Y, Wang J, Wang S, Wang S, Wang W, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xiao ZX, Xie Z, Xiong W, Xu D, Yang Z, Ye J, Yu W, Yue R, Zhang C, Zhang H, Zhang L, Zhang X, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhou Z, Zhu D, Zou W, Pei G, Liu GH. The Aging Biomarker Consortium represents a new era for aging research in China. Nat Med. 2023 Sep;29(9):2162-2165.
  5. Liu X, Ma Y, Yu Y, Zhang W, Shi J, Zhang X, Dai M, Wang Y, Zhang H, Zhang J, Shen J, Zhang F*, Song M*, Wang J*. Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract. Protein Cell. 2023 Apr 21;14(4):309-313.
  6. Ma Y, Liu X, Zhang X, Yu Y, Li Y, Song M*, Wang J*. Efficient Mining of Anticancer Peptides from Gut Metagenome. Adv Sci. 2023 Sep;10(25):e2300107.
  7. Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo OJ, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao FH, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F*, Cao Z*, Chan P*, Chen C*, Chen G*, Chen HZ*, Chen J*, Ci W*, Ding BS*, Ding Q*, Gao F*, Han JJ*, Huang K*, Ju Z*, Kong QP*, Li J*, Li J*, Li X*, Liu B*, Liu F*, Liu L*, Liu Q*, Liu Q*, Liu X*, Liu Y*, Luo X*, Ma S*, Ma X*, Mao Z*, Nie J*, Peng Y*, Qu J*, Ren J*, Ren R*, Song M*, Songyang Z*, Sun YE*, Sun Y*, Tian M*, Wang S*, Wang S*, Wang X*, Wang X*, Wang YJ*, Wang Y*, Wong CCL*, Xiang AP*, Xiao Y*, Xie Z*, Xu D*, Ye J*, Yue R*, Zhang C*, Zhang H*, Zhang L*, Zhang W*, Zhang Y*, Zhang YW*, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G*, Liu GH*. Biomarkers of aging. Sci China Life Sci. 2023 May;66(5):893-1066.
  8. Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells. Protein Cell. 2022 Sep;13(9):676-682.
  9. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing heterochromatin by APOE mediates senescence. Nat Aging. 2022 Apr;2(4):303-316.
  10. Shen J, Liu GH*, Song M*. Potential approaches for intervening aging. Natl Sci Open, 1 2 (2022) 20220021.
  11. Yu Y, Liu B, Liu X, Zhang X, Zhang W, Tian H, Shui G, Wang W, Song M*, Wang J*. Mesenteric lymph system constitutes the second route in gut-liver axis and transports metabolism-modulating gut microbial metabolites. J Genet Genomics. 2022 Jul;49(7):612-623.
  12. Chen L, Zhao N, Cao J, Liu X, Xu J, Ma Y, Yu Y, Zhang X, Zhang W, Guan X, Yu X, Liu Z, Fan Y, Wang Y, Liang F, Wang D, Zhao L, Song M*, Wang J*. Short- and long-read metagenomics expand individualized structural variations in gut microbiomes. Nat Commun. 2022 Jun 8;13(1):3175.
  13. Li W, Zou Z, Cai Y, Yang K, Wang S, Liu Z, Geng L, Chu Q, Ji Z, Chan P, Liu GH*, Song M*, Qu J*, Zhang W*. Low-dose chloroquine treatment extends the lifespan of aged rats. Protein Cell. 2022 Jun;13(6):454-461.
  14. Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang CL, Ying Y, Dou X, Chen Y, Xiao FH, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S*, Wang S*, Song X*, Ren J*, Zhang L*, Wang J*, Zhang W*, Xie Z*, Qu J*, Wang J*, Xiao Y*, Tian Y*, Wang G*, Hu P*, Ye J*, Sun Y*, Mao Z*, Kong QP*, Liu Q*, Zou W*, Tian XL*, Xiao ZX*, Liu Y*, Liu JP*, Song M*, Han JJ*, Liu GH*. The landscape of aging. Sci China Life Sci. 2022 Dec;65(12):2354-2454.
  15. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-cell transcriptomic atlas of primate cardiopulmonary aging. Cell Res. 2021 Apr;31(4):415-432.
  16. Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH*, Wang S*, Song M*, Qu J*. SIRT3 consolidates heterochromatin and counteracts senescence. Nucleic Acids Res. 2021 May 7;49(8):4203-4219.
  17. Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction. Protein Cell. 2021 Feb;12(2):145-151.
  18. Ma S#, Sun S#, Geng L#, Song M#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020 Mar 5;180(5):984-1001.e22.
  19. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W*, Song M*, Liu GH*, Qu J*. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell. 2020 Jul;11(7):483-504.
  20. Zhang J, Liu GH*, Qu J*, Song M*. Treating osteoarthritis via gene therapy with rejuvenation factors. Gene Ther. 2020 Aug;27(7-8):309-311.
  21. Wang Y, Li Y, He C, Gou B, Song M. Mitochondrial regulation of cardiac aging. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1853-1864.
  22. Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell. 2019 Jun;10(6):417-435.
  23. Zhang W#, Song M#, Qu J, Liu GH. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circ Res. 2018 Sep 14;123(7):773-786.
  24. Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell. 2018 Nov;9(11):945-965.
  25. Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metab. 2017 Dec 5;26(6):872-883.e5.
  26. Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015 Dec 4;350(6265):aad2459.
  27. Song M, Dorn GW 2nd. Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart. Cell Metab. 2015 Feb 3;21(2):195-205.
  28. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 2015 Feb 3;21(2):273-286.
  29. Song M, Gong G, Burelle Y, Gustafsson AB, Kitsis RN, Matkovich SJ, Dorn GW 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res. 2015 Jul 31;117(4):346-51.
  30. Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd. Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circ Res. 2014 Jul 18;115(3):348-53.