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Name:
 Moshi Song
Subject:
 Pathology and Pathophysiology
Tel/Fax:
 +86-10-64807079  / 
E-mail:
 songmoshi@ioz.ac.cn
Address:
 Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
 Group of Mitochondrial Disease      
Resume:

Prof. Moshi Song is a Principal Investigator at the Institute of Zoology of the Chinese Academy of Sciences. She obtained her Master’s degree in Biomedicine at Karolinska Institute (Sweden) and her Ph.D. in Molecular Cell Biology at Washington University in St. Louis (USA). She then completed her postdoctoral training at the Cardiovascular Research Institute of Stanford University (USA). In early 2018, She joined the Institute of Zoology, Chinese Academy of Sciences as a full-time Principal Investigator and established the Mitochondria and Disease Research Group. 

Her research is centered on unraveling the molecular mechanisms underlying cardiac aging and developing innovative interventive strategies for cardiac aging and related diseases. Utilizing human cellular aging models and animal models of cardiovascular aging and related diseases, her work aims to elucidate key molecular mechanisms, identify clinically relevant biomarkers, and develop novel therapeutic interventions. She has over 100 publications that have garnered over 9,200 citations, with an H-index of 47. In the past five years, she has served as corresponding or co-corresponding author on 34 publications in SCI journals such as Cell, Circulation Research (x2), Nature Aging (x2), Nature Communications (x2), Cell Research, iMeta, and Advanced Science (x3), with an average impact factor of over 13. She has also filed 23 invention patents, of which 9 have been granted.

Research Interests:

Mechanisms and Interventions of Cardiac Aging and Related Diseases

Awards and Honors:

Professional Activities:

Secretary General of Chinese Society for Aging Cell Research in Chinese Society for Cell Biology.

Deputy Director-General of Committee of Antiaging in Chinese association of Gerontology and Geriatrics.

Council member of Chinese Society for Cell Biology.

Council member of Chinese association of Gerontology and Geriatrics.

Committee member of Academic Subgroup of Free Radical Biology and Free Radical Medicine in the Biophysical Society of China.

Committee member of Mitochondrial Biology Academic Subgroup in the Biophysical Society of China.

Editorial board member of Life Medicine.

Editorial board member of Translational Medicine of Aging.

Editorial board member of The Journal of Cardiovascular Aging.

Research Grants:

Selected Publications:
  1. Du H, You X, Zhang J, Liu S, Zhou Y, Wang Y, Yang C, Meng Y, Liu X, Zhang H, Li Y, Shen J, Yuan H, Xu P, He C, Xiao Y, Gao Z, Zang J, Wei T*, Song M*. CAR Macrophages Engineered In Vivo for Attenuating Myocardial Ischemia-Reperfusion Injury. Circulation Research (Featured Article). 2025 Aug 29;137(6):846-859. 
  2. Geng L, Ping J, Wu R, Yan H, Zhang H, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J, Wen Y, Jing Y, Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, Diao Z, Li M, Zhang H, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, Wang W, Ji Y, Gou B, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q, Cao T, Yang S, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y, Li Y, Li J, Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S*, Song M*, Zhang W*, Qu J*, Liu GH*. Systematic Profiling Reveals Betaine as an Exercise Mimetic for Geroprotection. Cell. 2025 Jun 25:S0092-8674(25)00635-X. 
  3. Xiao Y, Zhang H, Liu X, Xu P, Du H, Wang J, Shen J, Li Y, Wang Y, He C, Feng H, Liu J, Zhou Y, Liu S, Gao Z, Zang J, Bi J, Tang TS, Gu Q, Wei T, Wang J, Song M*. Medium From Human iPSC-Derived Primitive Macrophages Promotes Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Nature Communications. 2025 Mar 27;16(1):3012. 
  4. Du H, Liu X, Shen J, Yuan H, Zhang H, Xi G, Li Y, Wang Y, Zhang J, Yang C, Xu P, Wang J, Wang F, Liu S, Zhou Y, Gu Q, Lu J, Wei T, Gao Z, Zang J, Wang J*, Song M*. Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury. Advanced Science (Frontispiece Article). 2025 Mar 16:e2417827. 
  5. Xiao Y, Xu P, Bi J, Song M*. Human iPSC-Derived Self-Assembled Cardiac Organoids for Evaluating Drug Developmental Cardiotoxicity. Life Medicine. 2025;4(4):lnaf018. 
  6. Wang J, Du H, Xie W, Bi J, Zhang H, Liu X, Wang Y, Zhang S, Lei A, He C, Yuan H, Zhang J, Li Y, Xu P, Liu S, Zhou Y, Shen J, Wu J, Cai Y, Yang C, Li Z, Liang Y, Zhao Y, Zhang J*, Song M*. CAR-Macrophage Therapy Alleviates Myocardial Ischemia-Reperfusion Injury. Circulation Research (Cover Story). 2024 Oct 28. 
  7. Wang J*, Wang W, Zhang J, Xiao F, Li Z, Xu P, Wang H, Du H, Liu S, Li H, Zhang X, Chen S, Gao Z, Wang S, Wang J*, Song M*. Deficiency of Flavin-Containing Monooxygenase 3 Protects Kidney Function After Ischemia-Reperfusion in Mice. Communications Biology. 2024 Aug 27;7(1):1054. 
  8. Su S, He C, Ren J*, Song M*. Global Insights Into Aging: A Multidisciplinary Approach to Understanding and Addressing Age-Related Challenges. Life Medicine. 2024 June;3(3):lnae029. 
  9. Zhang H, Wang J, Shen J, Chen S, Yuan H, Zhang X, Liu X, Yu Y, Li X, Gao Z, Wang Y, Wang J*, Song M*. Prophylactic Supplementation With Bifidobacterium infantis or Its Metabolite Inosine Attenuates Cardiac Ischemia/Reperfusion Injury. iMeta. 2024 Jul 2;3(4):e220. 
  10. Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J*, Song M*. Prophylactic Supplementation With Lactobacillus reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury. Advanced Science (Frontispiece Article). 2024 Mar 15:e2307233. 
  11. Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR Exerts Differential Levels of Metabolic Control in Human Embryonic, Mesenchymal and Neural Stem Cells. Protein Cell. 2022 Sep;13(9):676-682. 
  12. Shen J, Liu GH*, Song M*. Potential Approaches for Intervening Aging. National Science Open. 2022;1(2):20220021. 
  13. Zhang J, Liu GH*, Qu J*, Song M*. Treating Osteoarthritis Via Gene Therapy With Rejuvenation Factors. Gene Therapy. 2020 Aug;27(7-8):309-311. 
  14. Wang Y, Li Y, He C, Gou B, Song M*. Mitochondrial Regulation of Cardiac Aging. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019 Jul 1;1865(7):1853-1864. 
  15. Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metabolism. 2017 Dec 5;26(6):872-883.e5. 
  16. Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd. Parkin-Mediated Mitophagy Directs Perinatal Cardiac Metabolic Maturation in Mice. Science. 2015 Dec 4;350(6265):aad2459. 
  17. Song M, Dorn GW 2nd. Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart. Cell Metabolism. 2015 Feb 3;21(2):195-205. 
  18. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd. Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts. Cell Metabolism. 2015 Feb 3;21(2):273-286. 
  19. Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circulation Research. 2015 Jul 31;117(4):346-51. 
  20. Song M#, Matkovich SJ#, Zhang Y, Hammer DJ, Dorn GW 2nd. Combined Cardiomyocyte PKCδ and PKCε Gene Deletion Uncovers Their Central Role in Restraining Developmental and Reactive Heart Growth. Science Signaling. 2015 Apr 21;8(373):ra39. 
  21. Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd. Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy. Circulation Research. 2014 Jul 18;115(3):348-53.