Research Interests:

Mosquitoes are vectors of many human pathogens including dengue virus, Zika virus, chikungunya virus, yellow fever virus, West Nile virus, Mayaro virus, and malaria. Roughly half of the world’s population is at risk of these diseases, with the highest burden falling on socially and economically disadvantaged populations. Dengue incidence has increased over 30-fold in the past 50 years, currently resulting in over 400 million new infections per year. The research group uses genomics as the main method, based on genomics, gene editing, microbial isolation and screening, aseptic system, and other methods to explore the interactions between host and microbiota, and develop new technologies using microbiome and genome editing for mosquito control. 1. New mosquito control technologies based on the microbiome and gene editing/drive Developing new economic, sustainable, and environment-friendly mosquito control technologies based on the microbiome and gene editing. 2. Microbial function mining Using parasitic wasps and mosquitoes as model systems, we will deeply explore the role of microorganisms in the evolution of host adaptability and drug resistance. 3. Microbial structure regulation mechanisms Using metagenomics, metabolomics, gene editing, and aseptic system, we will focus on the molecular and physiological mechanisms how the host regulates microbiota structure, providing the theoretical basis for the establishment of microbial technology for pest control. Research Areas: Entomology; Microbiology; Genomics; Biological Engineering;

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:

（#co-first author, *corresponding author） 9. Huihui Sun, Guan-Hong Wang*. 2024. Microbial Alchemists Unlock Honeybee Cognition. Cell Host & Microbe. 8. Guan-Hong Wang*, Ary Hoffmann*, Jackson Champer*. 2024. Gene drive and symbiont technologies for control of mosquito-borne diseases. Annual Review of Entomology. 7. Ronger Zheng, Qiqi Wang, Runbiao Wu, Prasad N Paradkar, Ary A Hoffmann, Guan-Hong Wang*. 2023.Holobiont perspectives on tripartite interactions among microbiota, mosquitoes, and pathogens. The ISME Journal 17:1143-1152. 6. Jiahui Wu, Qiqi Wang, Dandan Wang, Adam CN Wong, Guan-Hong Wang*. 2023. Axenic and gnotobiotic insect technologies in host-microbiota interaction research. Trends in Microbiology 31:858-871. 5. Zhengyu Zhu, Yanjun Liu, Haoyuan Hu, Guan-Hong Wang*. 2023. Nasonia-microbiome associations: a model for evolutionary hologenomics research. Trends in Parasitology 39:4-17. 4. Guan-Hong Wang*, Jie Du, Chen Yi Chu, Mukund Madhav, Grant L. Hughes, Jackson Champer* 2022. Symbionts and gene drive: two strategies to combat vector-borne disease. Trends in Genetics 38:708-23. 3. Wang, G.-H.#, Stephanie Gamez#, Robyn Raban#, John Marshall, Luke Alphey, Ming Li, Jason Rasgon, Omar S. Akbari*. 2021. Combating mosquito-borne pathogens using genetic control technologies. Nature Communications12, 4388. 2. Wang G-H, Dittmer J, Douglas B, Huang L, Brucker RM*. 2021. Coadaptation between host genome and microbiome under long-term xenobiotic-induced selection. Science Advances 7, eabd4473. 1. Wang, G.-H., B. M. Berdy, O. Velasquez, N. Jovanovic, S. Alkhalifa, K. P. C. Minbiole, and R. M. Brucker. 2020. Changes in Microbiome Confer Multigenerational Host Resistance after Sub-toxic Pesticide Exposure. Cell Host & Microbe 27:213-224.e217.