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Name:
 Yan-Ling WANG
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807195  / 
E-mail:
 wangyl@ioz.ac.cn
Address:
 The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
 Group of Reproductive Pathology      
Resume:

Yan-Ling Wang, Ph.D., professor, principal investigator, group leader of reproductive pathology group, Institute of Zoology, Chinese Academy of Sciences. She completed her undergraduate studies at the University of Science and Technology of China in 1993 and earned her Ph.D. in Physiology from the Institute of Zoology, Chinese Academy of Sciences, in 1998 under the mentorship of Professor Lin-Zhi Zhuang. She was promoted to professor in 2004. Dr. Wang has been presiding over the "National Outstanding Youth Science Fund", National Key Research and Development Program of China, Major Research Project and Key Research Project of National Natural Science Foundation of China, among others.

Dr. Wang's laboratory has predominantly concentrated on elucidating the mechanisms underlying placental development and the pathogenesis of reproductive-related diseases. Significant progress has been achieved in comprehending the dynamics of placental nutrient transport and metabolic patterns, which are pivotal in determining cell fate. Additionally, the regulatory mechanisms of uterine spiral artery remodeling and the cellular and molecular regulation of maternal-fetal interface immune adaptation have been elucidated. The roles of multicellular interactions at the maternal-fetal interface in the onset and progression of conditions such as preeclampsia, recurrent miscarriage, and fetal growth restriction have been clarified. Over one hundred peer-reviewed papers have been published in journals including Cell Stem Cell, Natl Sci Rev, and PNAS. Dr. Wang received numerous honors, include the " National Science and Technology Progress Award" second prize, the “National Maternal and Child Health Science and Technology Award” second prize, the "Huaxia Medical Science and Technology Award", and the "Chinese Academy of Sciences Zhu Li yuehua Outstanding Teacher Award". Dr. Wang is currently mentoring 12 graduate students, comprising 10 PhD candidates and 2 master's students.

Research Interests:

Awards and Honors:

Professional Activities:

Dr. Wang holds the position of Chinese Regional Editor-in-Chief for the Placenta journal, serves as an editorial board member for the Biol Reprod journal, and represents China on the executive committee of the international pregnancy joint organization, CoLab. She is the Vice-Chairperson of the Reproductive Immunology Branch of the Chinese Immunology Society. She serves as a standing committee member for both the Reproductive Biology Branch of the Chinese Zoological Society and the Reproductive Medicine Branch of the Beijing Medical Association. She is a director of the Reproductive Science Specialty Committee of the Chinese Physiological Society.

Research Grants:
  • National Natural Science Foundation Innovative Research Group Project (Grant No. 82421003): Embryonic Development and Reproductive Health (P.I. 2025.01-2029.12). Amount: RMB 1,600,000/10,000,000
  • National Key Research and Development Program (Grant No. 2022YFC2702400): Regulatory Mechanisms of Placental Development and Function (P.I. 2022.12-2025.11). Amount: RMB 3,400,000/10,000,000
  • National Key Research and Development Program (Grant No. 2021YFC2700303): Abnormal cell linage development, embryo suspension and early abortion (P.I., 2021.12-2024.11). Amount: RMB 3,000,000
  • National Key Research and Development Program (Grant No. 2018YFC1004100): Molecular mechanisms of placenta formation (P.I. 2018.12-2021.12). Amount: RMB 2,540,000/27,300,000
  • National Natural Science Foundation of China Key Research Project (Grant No. 81730040): The mechanism of steroid hormone synthesis and metabolism disturbance during pregnancy leading to the development of preeclampsia (P.I. 2018.01-2022.12). Amount: RMB 2,940,000
  • National Natural Science Foundation Major Research Project (Grant No. 81490740): Pathological mechanisms of recurrent spontaneous abortion and preeclampsia caused by abnormal feto-maternal interactions (P.I., 2015.01-2019.12). Amount: RMB 1,800,000
  • The National Natural Science Foundation for Distinguished Young Scholars (Grant No. 81025004): Placenta development and the pathogenesis of preeclampsia (P.I., 2011.01-2014.12). Amount: RMB 2,000,000

Selected Publications:
  1. Yu X#, Wu H#, Su J#, Liu X, Liang K, Li Q, Yu R, Shao X, Wang H*, Wang YL*, Shyh-Chang N*. Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells. Cell Stem Cell. 2024 Sep 5;31(9):1280-1297.e7.
  2. Jia W#, Ma L#, Yu X#, Wang F, Yang Q, Wang X, Fan M, Gu Y, Meng R, Wang J, Li YX, Li R*, Shao X*, Wang YL*. Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss. Natl Sci Rev. 2024 Apr 11;11(6):nwae142.
  3. Zheng W#, Zhang Y#, Xu P, Wang Z, Shao X, Chen C, Cai H, Wang Y, Sun MA, Deng W, Liu F, Lu J, Zhang X, Chen D, Mysorekar IU, Wang H, Wang YL*, Hu X*, Cao B*. TFEB safeguards trophoblast syncytialization in humans and mice. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2404062121.
  4. Ma Y#, Yu X#, Ye S#, Li W, Yang Q, Li YX, Wang Y*, Wang YL*. Immune-regulatory properties of endovascular extravillous trophoblast cells in human placenta. Placenta. 2024 Jan;145:107-116.
  5. Li Y, Li Z, Wang C, Yang M, He Z, Wang F, Zhang Y, Li R, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Shi P, Wang N, Wei Z, Wang YL, Jin L, Du P, Dong J, Jiao J. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell. 2023 Dec;186(26):5892-5909.e22.
  6. Shao X#, Yang Y#, Liu Y#, Wang Y#, Zhao Y, Yu X, Liu J, Li YX, Wang YL*. Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta. J Pineal Res. 2023:e12913.
  7. Shao X#, Yu W#, Yang Y#, Wang F, Yu X, Wu H, Ma Y, Cao B*, Wang YL*. The mystery of the life tree: the placenta. Biol Reprod. 2022; 25;107(1):301-316.
  8. Li Y#, Li Z#, Yang M#, Wang F#, Zhang Y#, Li R#, Li Q, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Ong J, Teng Z, Jin L*, Wang YL*, Du P*, Jiao J*. Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell. 2022;29(4):620-634.e6.
  9. Chen J#, Du L#, Wang F#, Shao X#, Wang X, Yu W, Bi S, Chen D, Pan X, Zeng S, Huang L, Liang Y, Li Y, Chen R, Xue F, Li X, Wang S, Zhuang M, Liu M, Lin L, Yan H, He F, Yu L, Jiang Q, Xiong Z, Zhang L, Cao B*, Wang YL*, Chen D*. Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at mid-gestation highlights the defective impacts on fetal health. Cell Prolif. 2022;55(4):e13204.
  10. Li G#, Wang Y#, Cao G#, Ma Y, Li YX, Zhao Y*, Shao X*, Wang YL*. Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia. J Biomed Sci. 2022;29(1):8.
  11. Ma Y#, Yu X#, Zhang L#, Liu J, Shao X, Li YX, Wang YL*. Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy. Biol Reprod. 2021 Mar 11;104(3):624-637.(Editorial Choice; Faculty Opinions)
  12. Shao X#, Cao G#, Chen D#, Liu J, Yu B, Liu M, Li YX, Cao B*, Sadovsky Y*, Wang YL*. Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply. Proc Natl Acad Sci U S A. 2021;118(3):e2017092118.
  13. Wang F#, Jia W#, Fan M#, Shao X#, Li Z, Liu Y, Ma Y, Li YX, Li R*, Tu Q*, Wang YL*. Single-cell immune landscape of human recurrent miscarriage. Genomics Proteomics Bioinformatics. 2021;S1672-0229(21)00003-6. (Editorial Highlight)
  14. Liu J#, Shao X#, Qin W#, Yanling Zhang#, Dang F, Yang Q, Yu X, Li YX, Chen X, Wang C*, Wang YL*. Quantitative chemoproteomics reveals O-GlcNAcylation of Cystathionine γ-lyase (CSE) represses trophoblast syncytialization. Cell Chem Biol. 2021;S2451-9456(21)00050-7. (Cover story)
  15. Ma Y#, Yang Q#, Fan M#, Zhang L, Gu Y, Jia W, Li Z, Wang F, Li YX, Wang J, Li R*, Shao X*, Wang YL*. Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation. Cell Prolif. 2020;53(5):e12802.
  16. Shao X#, Wang Y#, Liu Y, Guo X, Li D, Huo R, Jia W, Cao G, Li YX, Liu M, Sha J, Zhao Y, Wang YL*. Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia. J Hypertens. 2019;37:197–205
  17. Shao X#, Liu Y#, Liu M, Wang Y, Yan L, Wang H, Ma L, Lia YX, Zhao Y*, Wang YL*. Testosterone represses estrogen signaling via upregulating mir-22: mechanism for imbalanced steroid hormone production in preeclampsia. Hypertension. 2017;69:721-730. (Editorial highlight)
  18. Xu P#, Zhao Y#, Liu M, Wang Y, Wang H, Li YX, Zhu X, Yao Y, Wang H, Qiao J, Ji L*, Wang YL*. Variations of micrornas in human placentas and plasma from preeclamptic pregnancy. Hypertension. 2014;63:1276-1284.
  19. Ji L#, Brkić J#, Liu M#, Fu G, Peng C*, Wang YL*. Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia. Mol Asp Med. 2013;34:981-1023.