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Name:
 WANG Hongmei
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807187  /  +86-10-64807189
E-mail:
 wanghm@ioz.ac.cn
Address:
 Institute of Stem Cell and Regenerative, Chinese Academy of Siences, Yard A3, Datun Road, Chaoyang District, Beijing, 100101, P.R.China
More:
 Group of Reproductive Physiology      
Resume:

CURRICULA VITAE

Hongmei Wang is a professor of the State Key Laboratory of Stem Cell and Reproductive Biology (SRLab), Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS) and the Innovation Academy for Stem Cell and Regeneration (IASCR), CAS. She is currently the deputy director of IOZ, the director of SRLab and the vice president of IASCR. She is also the chairman of the Chinese Society of Reproductive Biology. She received her Bachelor’s (1995) and Master’s (1998) degrees in Cell Biology from Beijing Normal University and her Ph. D degree (2002) in Reproductive Biology from IOZ. Hongmei had her postdoctoral training (2003-2005) in Ottawa Health Research Institute, University of Ottawa. She joined SRLab in 2006 and since then she and her research team are committed to utilizing various models including human, non-human primate and mouse embryos and extraembryonic tissues, as well as stem cell-based embryo models and organoids to unravel the fundamental events and mechanisms of mammalian early embryo development and placentation. Additionally, they seek to establish the relationship between the anomalies in embryo and placental development and the onset of birth defects or gestational related diseases.

Research Interests:

Wang Lab is aimed at investigating the molecular mechanisms involved in placental development, particularly in the area of epithelial-mesenchymal transition (EMT), invasion/migration and syncytialization of the trophoblast lineage and placentation-related diseases, such as fetal growth restriction (FGR), pre-eclampsia and hydatidiform moles.

The overall goals of our research are: 1) to better understand the molecular events involved in placental trophoblast differentiation; 2) to provide potential biomarkers or candidate molecules for the diagnosis and treatment of pregnancy-related diseases including pre-eclampsia and FGR.

Placental villous trophoblast cells undergo terminal differentiation and fusion to form the multinucleated syncytiotrophoblast, while the extravillous cytotrophoblast infiltrates the endomyometrium to anchor the placenta. Inadequate/excessive invasion of trophoblast or dysregulation in syncytialization results in early pregnancy loss, pre-eclampsia, fetal growth restriction (FGR), hydatidiform moles or choriocarcinomas. The main research interest of my laboratory is to study the physiological and pathological mechanisms of placentation and related diseases, especially the key events including trophoblast invasion/migration and syncytialization. For many years, my lab has been working on key factors/pathways involved in embryo implantation and placentation, and has gained valuable information of the important functions of the ubiquitin-proteasome pathway, TGF-β signaling pathway, proprotein convertases and corticosteroid-binding globulin (CBG) in embryo implantation and placentation. By combining placenta-specific knockout or knockdown, gene nucleotide polymorphism analysis and cutting-edge molecular methods, we are continuing to uncover novel mechanisms involving the aforementioned factors and pathways in placentation.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Yu D#, Wan H#, Tong C#, Guang L#, Chen G#, Su J#, Zhang L, Wang Y, Xiao Z, Zhai J, Ma W, Liang K, Liu T, Wang Y, Peng Z, Luo L, Yu R, Li W*, Qi H*, Wang H*, Shyh-Chang N*. A multi-tissue metabolome atlas reveals core signatures and critical nodes of metabolic reprogramming in female primates during pregnancy. Cell. 2024, 187, 764-781 e714.1.
  2. Wang M#, Liu Y#, Sun R#, Liu F#, Li J, Yan L, Zhang J, Xie X, Li D, Wang Y, Li S, Zhu X, Li R*, Lu F*, Xiao Z*, Wang H*. Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy. Nat Genet. 2024, 56, 294-305.
  3. Wang Y#, Deng W#, Lee D#, Yan L#, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank BR, Ha J, Kang M, Yang M, Gong P, Lorenzi PL, Tan L, Gallup TD, Tang SK, Yang Z, Li J, Sanford NN, Wang H*, Kim BYS*, Jiang W*. Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics. Nat Nanotechnol. 2024,19, 255-263.
  4. Wu H#, Zhai J#, Wang H*. Unraveling the function of FGF signaling in human hypoblast specialization. Cell Stem Cell. 2024, 31(7):945-946. (comments)
  5. Yu X#, Wu H#, Su J#, Liu X, Liang K, Li Q, Yu R, Shao X, Wang H*, Wang YL*, Shyh-Chang N*. Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells. Cell Stem Cell. 2024, 31(9):1280-1297.e7.
  6. Wu X#, Zhai J#, Li Q#, Wang H*. The in vitro culture of mammalian embryos. Nat Method.2023, 20, 1855-1858. (comments)
  7. Wu H#, Huang XY#, Sun MX#, Wang Y#, Zhou HY#, Tian Y#, He BJ, Wu AP, Wang H*, Qin CF*. Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids. Nat Commun. 2023, 14, 5541.
  8. Zhai J#, Xu Y#, Wan H#, Yan R#, Guo J#, Skory R#, Yan L, Wu X, Sun F, Chen G, Zhao W, Yu K, Li W*, Guo F*, Plachta N*, Wang H*. Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture. Cell. 2023, 186(10). cover story.
  9. Jiang X #, Zhai J #, Xiao Z#, Wu X#, Zhang D#, Wan H, Xu Y, Qi L, Wang M, Yu D, Liu Y, Wu H, Sun R, Xia S, Yu K, Guo J, Wang H*. Identifying a dynamic transcriptomic landscape of the cynomolgus macaque placenta spanning during pregnancy at single-cell resolution. Dev Cell. 2023 Apr; 58:806-821.
  10. Jiang X#*, Wang Y# , Xiao Z, Yan L, Guo S, Wang Y, Wu H, Zhao X, Lu X*, Wang H*. A differentiation roadmap of murine placentation at single-cell resolution. Cell Discov. 2023 Mar;9(1):30.
  11. Zhai J#, Guo J#, Wan H#, Qi L#, Liu L#, Xiao Z, Yan L, Schmitz DA, Xu Y, Yu D, Wu X, Zhao W, Yu K, Jiang X*, Guo F*, Wu J*, Wang H*. Primate gastrulation and early organogenesis at single-cell resolution. Nature. 2022 Dec;612(7941):732-738.
  12. Zhou JJ#, Jiang XX#, Wu HW#, Zhang LJ, Chen M, Chen M, Shen ZM, Guo XD*, Wang H*, Gao F*, Dissecting the fate of 1 Foxl2-expressing cells in fetal ovary using lineage tracing and Single-Cell Transcriptomics. Cell Discov. 2022 Dec;8(1):139.
  13. Yan R#, Cheng X#, Gu C#, Xu YH#, Long X#, Zhai JL, Sun FY, Qian JJ, Du YR, Wang H*, Guo F*, Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development. Nat Genet. 2023 Jan, 55(1):130-143.
  14. Li Q#, Wu H#, Wang Y, # Wang H*, Current understanding in deciphering trophoblast cell differentiation during human placentation. Biol Reprod. 2022, 107(1):317-326. Review
  15. Gu Z#, Guo J#, Zhai J#, Feng G, Wang X, Gao Z, Li K, Ji S, Wang L, Xu Y, Chen X, Wang Y, Guo S, Yang M, Li L,Hua H, Jiang L, Wen Y, Wang L, Hao J, Li W, Wang S,* Wang H*, Gu Q*. A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis. Adv Sci. 2022,10.1002.
  16. Tu W#, Ni D#, Yang H#, Zhao F#, Yang C#, Zhao X#, Guo Z#, Yu K, Wang J, Hu Z, Chen Z, Zhao Y, Wang Z, Gao F, Yan L*, Yang X*, Zhu L*, Wang H*. Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study. Sci Bull. 2022, 67(18): 1854-1859.
  17. Wang Y#, Jiang X#, Jia L#, Wu X#, Wu H#, Wang Y, Li Q, Yu R, Wang H*, Xiao Z*, Liang X*. A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization. Front Cell Dev Biol. 2022 Jun 15;10:835445.
  18. Wang Y#, Wu H#, Jiang X#, Jia L#, Wang M, Rong Y, Chen S, Wang Y, Xiao Z*, Liang X*, Wang H*. LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells. Front Cell Dev Biol. 2022 Apr 11;10:836390.
  19. Zhai J#, Xiao Z#, Wang Y#, Wang H*. Human embryonic development: from peri-implantation to gastrulation. Trends Cell Biol. 2022 Jan;32(1):18-29. Review
  20. Liang G#, Zhou C#, Jiang X#, Zhang Y, Huang B, Gao S, Kang Z, Ma D, Wang F, Gottgens B*, Wang H*, Han JJ*, Liu F*. De novo generation of macrophage from placenta-derived hemogenic endothelium. Dev Cell. 2021 Jul 26;56(14):2121-2133.
  21. Wu H#, Liao S#*, Wang Y#, Guo M#, Lin X, Wu J, Wang R, Lv D, Wu D, He M, Hu B, Long R, Peng J, Yang H, Yin H, Wang X, Huang Z, Lan K, Zhou Y, Zhang W, Xiao Z, Zhao Y*, Deng D*, Wang H*. Molecular evidence suggesting the persistence of residual SARS-CoV-2 and immune responses in the placentas of pregnant patients recovered from COVID-19. Cell Prolif. 2021 Sep;54(9):e13091.
  22. Yan R#, Gu C#*, You D, Huang Z, Qian J, Yang Q, Cheng X, Zhang L##, Wang H##, Wang P*, Guo F*. Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing. Cell Stem Cell. 2021, 28(9):1641-1656.e7.（##Senior author）
  23. Li X#, Wang Y#, Ma R#, Liu X, Song B, Duan Y, Guo J, Feng G, Cui T, Wang L, Hao J*, Wang H*, Gu Q*. Reconstruction of functional uterine tissues through recellularizing the decellularized rat uterine scaffolds by MSCs in vivo and in vitro. Biomed Mater. 16 (2021) 035023.
  24. Qu Y#, Chen Q#, Guo S#, Ma C, Lu Y, Shi J, Liu S, Zhou T, Noda T, Qian J, Zhang L, Zhu X, Lei X, Cao Y, Li W, Li W, Plachta N, Matzuk MM, Ikawa M, Duan *E, Zhang Y*, Wang H*. Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization. Protein Cell. 2021 Oct;12(10):810-817.
  25. Zhao Y#, Ma J#, Yi P#, Wu J#, Zhao F, Tu W, Liu W, Li T, Deng Y, Hao J*, Wang H*, Yan L*. Human umbilical cord mesenchymal stem cells restore the ovarian metabolome and rescue premature ovarian insufficiency in mice. Stem Cell Res Ther. 2020 Nov 4，11(1)，466.
  26. Yan L#, Wu Y#, Li L#, Wu J#, Zhao F, Gao Z, Liu W, Li T, Fan Y*, Hao J*, Liu J*, Wang H*. Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency. Cell Prolif. 2020, 53(12), e12938.
  27. Xiao Z#, Yan L#, Liang X*, Wang H*. Progress in deciphering trophoblast cell differentiation during human placentation. Curr Opin Cell Biol. 2020, 18(67), 86-91. (invited review)
  28. Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M,  Plachta N*. Keratins are asymmetrically inherited fate determinants in the mammalian embryo. Nature. 2020, 585(7825), 404-409.
  29. Ma H#, Zhai J#, Wan H#, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao ZA, Zhao B, Zheng P*, Li L*, Wang H*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science.2019, 366(6467): eaax7890.
  30. Guo S#, Cui X#, Jiang X#, Duo S, Li S, Gao F*, Wang H*. Tracing the origin of the placental trophoblast cells in mouse embryo development. Biol Reprod. 2020 Mar 13;102(3):598-606.
  31. Wang R#, Yu R#, Zhu C, Lin HY, Lu X*, Wang H*. Tubulin detyrosination promotes human trophoblast syncytium formation. J Mol Cell Biol. 2019, 11(11), 967-978. (cover story)
  32. Ma J#, Wu J#, Han L, Jiang X, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic plate under serum-free condition. Stem Cell Res Ther. 2019, 10(1), 19.
  33. Liu Y#, Fan X#, Wang R#, Lu X#, Dang YL, Wang H, Lin HY, Zhu C, Ge H, Cross JC*, Wang H* Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Res. 2018, 28(8), 819-832.
  34. Jiang X, Du MR, Li M, Wang H*. Three macrophage subsets are identified in the uterus during early human pregnancy. Cell Mol Immunol. 2018, 15(12), 1027-1037.
  35. Chang WL#, Liu YW#, Dang YL#, Jiang XX, Xu H, Huang X, Wang YL, Wang H, Zhu C, Xue LQ, Lin HY, Meng W*, Wang H*. Plac8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development. 2018, 145(2), dev148932.
  36. Lu X#, Wang R#, Zhu C, Wang H, Lin HY, Gu Y, Cross JC*, Wang H*. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Reports. 2017, 21(5), 1150-1159.