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Name:
 WANG Hongmei
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807187  /  +86-10-64807189
E-mail:
 wanghm@ioz.ac.cn
Address:
 Institute of Stem Cell and Regenerative, Chinese Academy of Siences, Yard A3, Datun Road, Chaoyang District, Beijing, 100101, P.R.China
More:
 Group of Reproductive Physiology      
Resume:

Hongmei Wang is a professor of State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS). She is the deputy director of the IOZ, serves as the chairman of the Chinese Society of Reproductive Biology, and is a member of the Scientific Advisory Board of the Loke Centre for Trophoblast Research at the University of Cambridge. She previously served as the director of the State Key Laboratory of Stem Cell and Reproductive Biology (2017-2025). She received her Bachelor’s (1995) and Master’s (1998) degrees in Cell Biology from Beijing Normal University and her Ph.D. degree (2002) in Physiology from IOZ. Hongmei had her postdoctoral training (2003-2005) at the Ottawa Health Research Institute, University of Ottawa. Her contributions have been recognized through major honors, including the Top 10 Scientific Advances in Life Sciences of China (China Union of Life Science Societies), the Tan Jiazhen Life Science Award, and the Anne McLaren Memorial Lecture at the ISSCR Annual Meeting.

Research Interests:

1) Mammalian Placental Development

The placenta is a transient organ that establish structural and functional connections between the fetus and mother during pregnancy. The human placenta plays a vital role for the health of both conceptus and fetus from conception onwards. Yet the developmental and functional specialization of its diverse cell types remain poorly understood. To fill this gap, our team systematically analyzed the key developmental events and regulatory mechanisms from the emergence of the first placental cell to the establishment of a functional placenta, and further elucidated how the placenta coordinates with multiple maternal organs to sustain fetal development.

Our team established trophoblast stem cell (TSC) lines based on Chinese population characteristics and investigated the spectrum of placental structure and function at different developmental stages in humans. Our team discovered multiple new cell types participating in the immune tolerance and new regulatory mechanisms (Cell Res, 2018). Our team constructed human placental organoid that simulate physiological and pathological states in vitro, and revealed new mechanisms by which the placenta resists SARS-CoV-2 and ZIKA virus invasion and protects fetal development (Nat Commun, 2023). For the key unit of human placenta-syncytiotrophoblast (a multinucleated structure containing billions of nuclei), our team used TSCs and organoid to depict the cellular and molecular basis of the syncytial layer and analyzed the mechanisms of heterogeneity during different gestational stages (Nat Genet, 2024; Cell Rep, 2017). By comparing the placental development of non-human primates (NHP) and mice, our team identified the unique features of NHP placental structure and function (Dev Cell, 2023; Cell Discov, 2023). Taking advantage of cynomolgus monkey model, our team elucidated the metabolic mechnisms through which the placenta coordinates with maternal organs to adaptively support fetal development, and proposed the value of ketones in the diagnosis of preeclampsia (Cell, 2024).

2) Primate Early Embryogenesis

Early human embryonic development sets the trajectory for health across the life course. Any aberrations in this process are associated with a heightened burden of adverse pregnancy outcomes. However, as embryonic development occurs within the uterus, direct observation has been severely limited by ethical and technical constraints. To address this, our team developed a long-term in vitro culture (IVC) system that supports continuous development of cynomolgus monkey embryos from fertilization through gastrulation, up to 20 days post-fertilization. This system enabled us to uncover key developmental events, including primitive streak formation, cell migration during gastrulation, and anterior-posterior axis establishment (Science, 2019). Our team further optimized the IVC system into a 3D culture platform, extending embryo development to day 25, corresponding to early organogenesis. This work unraveled the molecular mechanisms underlying the differentiation of all three germ layers and provided insights into early organ development, achieving the longest ex utero culture to date (Cell, 2023, Cover Story; Nat Protoc, 2024). In parallel, our team optimized embryo transfer techniques and ultrasound imaging to precisely capture in utero developing embryos, employed single-cell multi-omics to construct a comprehensive developmental atlas of gastrulation and early organogenesis, and then leveraged pluripotent stem cell-based models to validate the key molecular mechanisms governing the transition from gastrulation to early organogenesis. (Nature, 2022). 

3) Primate Ovarian Aging

Healthy oocytes are essential for the formation of fertilized eggs and normal embryonic development. The ovarian reserve of Chinese women at different ages remains largely unknown. There is still a lack of effective treatment to restore reproductive capacity in women with diminished ovarian function.

By innovating the stereological quantification method, our team mapped the age-dependent changes in oocyte reserve of Chinese women, elucidated the molecular mechanisms underlying the formation of the primordial follicle pool (Sci Bull, 2022; Cell Discov, 2024). To address the issue of infertility caused by either physiological or pathological ovarian aging, our team established clinical-grade mesenchymal stem cells (MSCs) from the placenta and associated tissues. By using MSCs and immunomodulatory and matrix-regulating cells (IMRCs) from the National Stem Cell Resource Center, our team demonstrated in both mouse and monkey models that safe doses of MSCs or IMRCs could improve the microenvironment for oogenesis, promote the recovery of hormone levels and fertility, without causing obvious adverse effects (Stem Cell Res Ther, 2020; Cell Discov, 2024). Ultimately, our team successfully applied MSCs in the clinical setting to enhance fertility in patients with premature ovarian insufficiency and enabled fertile outcomes. No obvious cell therapy-related adverse events were observed during the six-month follow-up period (Cell Prolif, 2020).

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:

（Notes: # indicates equal contribution; * indicates corresponding author; ## indicates senior author.）

  1. Clark AT, Cook-Andersen H, Franklin S, Isasi R, Mathews DJH, Pasque V, Rugg-Gunn PJ, Tam PPL, Wang H, Zylicz JJ, Rossant J. Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited. Stem Cell Rep. 2025, 20(6), 102514.
    (This Guidelines update underscores the ISSCR's steadfast commitment to proactively addressing the ethical and regulatory considerations that accompany scientific advances)
  2.  Qian Li#, Yang Yuan#, Wentao Zhao#, Yuanjun Li#, Juanzi Shi#, Yu Xiu#, Mi Han#, Junmei Zhang#, Yan Han, Shuhan Cheng, Xin Qi, Xizhuang Sun, Tan Jia, Jiaqi Xing, Siwei Deng, Xiaodi Yan, Seiya Oura, Hongfei Li, Ying Sun, Huiyao Yuan, Xiaohong Ma, Miaomiao Xin, Jianchao Zhao, Xili Zhu, Cong Wang, Qin Wang, Ge Lin, Xiaokui Yang*, Yulei Wei*, Jun Wu*, Wang H*, Leqian Yu*, A 3D In Vitro Model for Studying Human Implantation and Implantation Failures. Cell, 2025 (Acceptance in principle)
  3. Guo Z#, Zhao W#, Wang H##, Zhai J*. (2025). Recent insights into the in vitro culture systems for mammalian embryos. Curr Opin Genet Dev. 2025;91:102309. (Invited Review)
  4. Clark AT*, Goolam M*, Hanna JH*, Long K*, Nicol D*, Petropoulos S*, Saitou M*, Tam PPL*, Wang H*. Human developmental biology - a global perspective. Development. 2024 Sep 1;151(17):dev203092. (Invited Perspective)
  5. Xu Y#, Zhai J#, Wu H#, Wang H*. In vitro culture of cynomolgus monkey embryos from blastocyst to early organogenesis. Nat. Protoc. 2024 Dec;19(12):3677-3696.
  6. Wu H#, Zhai J#, Wang H*. Unraveling the function of FGF signaling in human hypoblast specialization. Cell Stem Cell. 2024, 31(7):945-946. (Invited Comment)
  7. Yan L#, Tu W#, Zhao X#, Wan H#, Wu J#, Zhao Y#, Wu J#, Sun Y#, Zhu L#, Qin Y#, Hu L#, Yang H#, Ke Q#, Zhang W#, Luo W#, Xiao Z#, Chen X#, Wu Q, He B, Teng M, Dai S, Zhai J, Wu H, Yang X*, Guo F*, Wang H*. Stem cell transplantation extends the reproductive life span of naturally aging cynomolgus monkeys. Cell Discov. 2024, 10(1):111.
  8. Yu D#, Luo L#, Wang H*, Shyh-Chang N*. Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses. Trends Endocrinol Metab. 2024, S1043-2760(24)00192-9. (Invited Review)
  9. Yu X#, Wu H#, Su J#, Liu X, Liang K, Li Q, Yu R, Shao X, Wang H*, Wang YL*, Shyh-Chang N*. Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells. Cell Stem Cell. 2024, 31(9):1280-1297.e7.
  10. Wang Y#, Deng W#, Lee D#, Yan L#, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank BR, Ha J, Kang M, Yang M, Gong P, Lorenzi PL, Tan L, Gallup TD, Tang SK, Yang Z, Li J, Sanford NN, Wang H*, Kim BYS*, Jiang W*. Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics. Nat Nanotechnol. 2024,19, 255-263.
  11. Yu D#, Wan H#, Tong C#, Guang L#, Chen G#, Su J#, Zhang L, Wang Y, Xiao Z, Zhai J, Ma W, Liang K, Liu T, Wang Y, Peng Z, Luo L, Yu R, Li W*, Qi H*, Wang H*, Shyh-Chang N*. A multi-tissue metabolome atlas reveals core signatures and critical nodes of metabolic reprogramming in female primates during pregnancy. Cell. 2024, 187, 764-781 e714.
  12. Wang M#, Liu Y#, Sun R#, Liu F#, Li J, Yan L, Zhang J, Xie X, Li D, Wang Y, Li S, Zhu X, Li R*, Lu F*, Xiao Z*, Wang H*. Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy. Nat Genet. 2024, 56, 294-305.
  13. Wu X#, Zhai J#, Li Q#, Wang H*. The in vitro culture of mammalian embryos. Nat Method.2023, 20, 1855-1858. (Invited Comment, Selected for Method of the Year 2023: methods for modeling development)
  14. Wu H#, Huang XY#, Sun MX#, Wang Y#, Zhou HY#, Tian Y#, He BJ, Wu AP, Wang H*, Qin CF*. Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids. Nat Commun. 2023, 14, 5541.
  15. Wu X#, Zhao W#, Wu H#, Zhang Q#, Wang Y, Yu K, Zhai J, Mo F, Wang M, Li S, Zhu X, Liang X, Hu B, Liu GH, Wu J##, Wang H##, Guo F*, Yu L*. An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation. Cell Prolif. 2023, e13492.
  16. Wu H#, Luo CX#, Rong Y, Yu RX, Zhao Y, Yan L*, Wang H*, Elucidating the dynamics of polypeptide hormones in the physiological and preeclampsic placental trophoblast cells across gestation at single-cell level. Life Med. 2023, 2(3): 8.
  17. Zhai J#, Xu Y#, Wan H#, Yan R#, Guo J#, Skory R#, Yan L, Wu X, Sun F, Chen G, Zhao W, Yu K, Li W*, Guo F*, Plachta N*, Wang H*. Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture. Cell. 2023, 186(10), 2078-2091.e18. (Cover Story)
  18. Jiang X #, Zhai J #, Xiao Z#, Wu X#, Zhang D#, Wan H, Xu Y, Qi L, Wang M, Yu D, Liu Y, Wu H, Sun R, Xia S, Yu K, Guo J, Wang H*. Identifying a dynamic transcriptomic landscape of the cynomolgus macaque placenta spanning during pregnancy at single-cell resolution. Dev Cell. 2023, 58, 806-821.
  19. Jiang X#*, Wang Y#, Xiao Z, Yan L, Guo S, Wang Y, Wu H, Zhao X, Lu X*, Wang H*. A differentiation roadmap of murine placentation at single-cell resolution. Cell Discov. 2023, 9(1), 30.
  20. Zhai J#, Guo J#, Wan H#, Qi L#, Liu L#, Xiao Z, Yan L, Schmitz DA, Xu Y, Yu D, Wu X, Zhao W, Yu K, Jiang X*, Guo F*, Wu J*, Wang H*. Primate gastrulation and early organogenesis at single-cell resolution. Nature. 2022, 612(7941), 732-738.
  21. Zhou JJ#, Jiang XX#, Wu HW#, Zhang LJ, Chen M, Chen M, Shen ZM, Guo XD*, Wang H*, Gao F*, Dissecting the fate of 1 Foxl2-expressing cells in fetal ovary using lineage tracing and Single-Cell Transcriptomics. Cell Discov. 2022, 8(1), 139.
  22. Yan R#, Cheng X#, Gu C#, Xu YH#, Long X#, Zhai JL, Sun FY, Qian JJ, Du YR, Wang H*, Guo F*, Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development. Nat Genet. 2023, 55(1), 130-143.
  23. Ma J#, Liu Y#, Guo Z#, Sun R#, Yang X, Zheng W, Ma Y, Rong Y, Wang H*, Yang H*, Xiao Z*. The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing. Front Cell Dev Biol. 2022, 10, 1044198.
  24. Gu Z#, Guo J#, Zhai J#, Feng G, Wang X, Gao Z, Li K, Ji S, Wang L, Xu Y, Chen X, Wang Y, Guo S, Yang M, Li L,Hua H, Jiang L, Wen Y, Wang L, Hao J, Li W, Wang S,* Wang H*, Gu Q*. A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis. Adv Sci (Weinh). 2022, 9(28), e2202282.
  25. Tu W#, Ni D#, Yang H#, Zhao F#, Yang C#, Zhao X#, Guo Z#, Yu K, Wang J, Hu Z, Chen Z, Zhao Y, Wang Z, Gao F, Yan L*, Yang X*, Zhu L*, Wang H*. Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study. Sci Bull. 2022, 67(18), 1854-1859.
  26. Yan L, Wang H*. Ketone bodies determine the female reproductive lifespan via regulating the ovarian reserve. Life Metab. 2022, Vol, 1, Issue 2, 101–102. (Research Highlight)
  27. Li Q#, Wu H#, Wang Y#, Wang H*, Current understanding in deciphering trophoblast cell differentiation during human placentation. Biol Reprod. 2022, 107(1), 317-326. (Invited Review)
  28. Wang Y#, Jiang X#, Jia L#, Wu X#, Wu H#, Wang Y, Li Q, Yu R, Wang H*, Xiao Z*, Liang X*. A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization. Front Cell Dev Biol. 2022, 10, 835445.
  29. Wang Y#, Wu H#, Jiang X#, Jia L#, Wang M, Rong Y, Chen S, Wang Y, Xiao Z*, Liang X*, Wang H*. LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells. Front Cell Dev Biol. 2022, 10, 836390.
  30. Zhai J#, Xiao Z#, Wang Y#, Wang H*. Human embryonic development: from peri-implantation to gastrulation. Trends Cell Biol. 2022, 32(1), 18-29. (Invited Review)
  31. Liang G#, Zhou C#, Jiang X#, Zhang Y, Huang B, Gao S, Kang Z, Ma D, Wang F, Gottgens B*, Wang H*, Han JJ*, Liu F*. De novo generation of macrophage from placenta-derived hemogenic endothelium. Dev Cell. 2021, 56(14), 2121-2133.
  32. Wu H#, Liao S#*, Wang Y#, Guo M#, Lin X, Wu J, Wang R, Lv D, Wu D, He M, Hu B, Long R, Peng J, Yang H, Yin H, Wang X, Huang Z, Lan K, Zhou Y, Zhang W, Xiao Z, Zhao Y*, Deng D*, Wang H*. Molecular evidence suggesting the persistence of residual SARS-CoV-2 and immune responses in the placentas of pregnant patients recovered from COVID-19. Cell Prolif. 2021, 54(9), e13091.
  33. Li X#, Wang Y#, Ma R#, Liu X, Song B, Duan Y, Guo J, Feng G, Cui T, Wang L, Hao J*, Wang H*, Gu Q*. Reconstruction of functional uterine tissues through recellularizing the decellularized rat uterine scaffolds by MSCs in vivo and in vitro. Biomed Mater. 2021, 16(3), 035023.
  34. Qu Y#, Chen Q#, Guo S#, Ma C, Lu Y, Shi J, Liu S, Zhou T, Noda T, Qian J, Zhang L, Zhu X, Lei X, Cao Y, Li W, Li W, Plachta N, Matzuk MM, Ikawa M, Duan *E, Zhang Y*, Wang H*. Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization. Protein Cell. 2021, 12(10), 810-817. (Letter)
  35. Cui D#, Liu Y#, Jiang X#, Ding C, Poon LC*, Wang H*, Yang H*. Single-cell RNA expression profiling of SARS-CoV-2-related ACE2 and TMPRSS2 in human trophectoderm and placenta. Ultrasound Obstet Gynecol. 2021, 57(2), 248-256.
  36. Zhao Y#, Ma J#, Yi P#, Wu J#, Zhao F, Tu W, Liu W, Li T, Deng Y, Hao J*, Wang H*, Yan L*. Human umbilical cord mesenchymal stem cells restore the ovarian metabolome and rescue premature ovarian insufficiency in mice. Stem Cell Res Ther. 2020, 11(1), 466.
  37. 王红梅*. 哺乳动物早期胚胎发育研究进展和伦理. 生物医学转化 2020, 1(1), 35-42.
  38. Yan L#, Wu Y#, Li L#, Wu J#, Zhao F, Gao Z, Liu W, Li T, Fan Y*, Hao J*, Liu J*, Wang H*. Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency. Cell Prolif. 2020, 53(12), e12938.
  39. Xiao Z#, Yan L#, Liang X*, Wang H*. Progress in deciphering trophoblast cell differentiation during human placentation. Curr Opin Cell Biol. 2020, 67, 86-91. (Invited Review) 
  40. Gao H, Liu C, Wu B, Cui H, Zhao Y, Duan Y, Gao F*, Gu Q*, Wang H*, and Li W*. Effects of Different Biomaterials and Cellular Status on Testicular Cell Self-Organization. Adv Biosyst. 2020, 4(7), e1900292.
  41. Jiang X*, Wang H*. Macrophage subsets at the maternal-fetal interface. Cell Mol Immunol. 2020, 17(8), 889-891.
  42. Guo S#, Cui X#, Jiang X#, Duo S, Li S, Gao F*, Wang H*. Tracing the origin of the placental trophoblast cells in mouse embryo development. Biol Reprod. 2020, 102(3), 598-606.
  43. Hong L#, Yan L#, Xin Z, Hao J, Liu W, Wang S, Liao S, Wang H*, Yang X*. Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. J Mol Cell Biol. 2020, 12(5), 372-385.
  44. Ma H#, Zhai J#, Wan H#, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao ZA, Zhao B, Zheng P*, Li L*, Wang H*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science. 2019, 366(6467). (Featured on the cover)
  45. Wang R#, Yu R#, Zhu C, Lin HY, Lu X*, Wang H*. Tubulin detyrosination promotes human trophoblast syncytium formation. J Mol Cell Biol. 2019, 11(11), 967-978. (Cover Story)
  46. Ma J#, Wu J#, Han L, Jiang X, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic plate under serum-free condition. Stem Cell Res Ther. 2019, 10(1), 19.
  47. Jiang Y#, Yan L#, Xia L, Lu X, Zhu W, Ding D, Du M, Zhang D, Wang H*, Hu B*. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. J Biol Chem. 2018, 293(50), 19317-19329 . 
  48. Wang Y, Wang H*. Successful derivation of human trophoblast stem cells. Biol Reprod. 2018, 99(2), 271-272. (Research Highlight) 
  49. Liu Y#, Fan X#, Wang R#, Lu X#, Dang YL, Wang H, Lin HY, Zhu C, Ge H, Cross JC*, Wang H* Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Res. 2018, 28(8), 819-832. (This work was highlighted in F1000)
  50. Jiang X, Du MR, Li M, Wang H*. Three macrophage subsets are identified in the uterus during early human pregnancy. Cell Mol Immunol. 2018, 15(12), 1027-1037.
  51. Chang WL#, Liu YW#, Dang YL#, Jiang XX, Xu H, Huang X, Wang YL, Wang H, Zhu C, Xue LQ, Lin HY, Meng W*, Wang H*. Plac8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development. 2018, 145(2), dev148932.
  52. Lu X#, Wang R#, Zhu C, Wang H, Lin HY, Gu Y, Cross JC*, Wang H*. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Rep. 2017, 21(5), 1150-1159.
  53. Jia Q, Cao C, Tang H, Zhang Y, Zheng Q, Wang X, Zhang R, Wang X, Luo A, Wei H, Meng A, Zhou Q*, Wang H*, Zhao J*. A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs. J Genet Genomics. 2017, 44, 215-217.
  54. Yan L#, Li Y#, Shi Z#, Lu X#, Ma J, Hu B, Jiao J*, Wang H*. The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem. 2017, 292(31), 12959-12970.
  55. Hai T#, Cao C#, Shang H#, Guo W#, Mu Y#, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao J*, Zhou Q*, Meng A*. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife. 2017, (6), e26248.
  56. Zhang Y#, Wang Q#, Wang H*, Duan EK*. Uterine Fluid in Pregnancy: A Biological and Clinical Outlook. Trends Mol Med. 2017, 23(7), 604–614. (Invited Review) 
  57. Liu D#, Mo G#, Tao Y, Wang H*, Liu XJ*. Putrescine supplementation during in vitro maturation of aged mouse oocytes improves the quality of blastocysts. Reprod Fertil Dev. 2017, 29(7), 1392-1400.
  58. 王红梅*，杜美蓉*.人类胎盘滋养层细胞的分化与妊娠相关疾病. 生命科学. 2017, 29(1), 15-20.
  59. Lu X#, Wang Y#, Yan L, Wang L, Li W, Wang H*. Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs. J Genet Genomics. 2016, 43(10), 609-612.
  60. Cui L#, Wang H#, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2. Cell Adh Migr. 2016, 10(1-2), 39-55.
  61. Nie M#, Yu S#, Peng S, Fang Y, Wang H*, Yang X*. miR-23a and miR-27a Promote Human Granulosa Cell Apoptosis by Targeting SMAD5. Biol Reprod. 2015, 93(4), 98, 1-10. 
  62. Zhang Q#, Yu S#, Huang X#, Tan Y, Zhu C, Wang Y, Wang H, Lin H, Fu J*, Wang H*. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction. 2015, 150(2), 139-149.
  63. Lei JH#, Yang X#, Peng S#, Li Y, Underhill C, Zhu C, Lin HY*, Wang H*, Hammond GL*. Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. J Clin Endocrinol Metab. 2015, 100(5), 1819-27. 
  64. Chang WL#, Yang Q#, Zhang H#, Lin HY, Zhou Z, Lu X, Zhu C, Xue LQ*, Wang H*. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction. 2014, 148(4), 343-352.
  65. Zhou Z#, Wang R#, Yang X, Lu XY, Zhang Q, Wang YL, Wang H, Zhu C, Lin HY*, Wang H*. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta. 2014, 35(11), 907-18. Placenta.
  66. Wang R#, Dang YL#, Zheng R, Li Y, Li W, Lu X, Wang LJ, Zhu C, Lin HY*, Wang H*. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod. 2014, 90(6), 117, 1-10 (Cover story).
  67. Li W, Liu D, Chang W, Lu X, Wang YL, Wang H, Zhu C, Lin HY, Zhang Y, Zhou J*, Wang H*. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell Death Dis. 2014, 5(1), e1025.
  68. Aguilar PS#, Baylies MK#, Fleissner A#, Helming L#, Inoue N#, Podbilewicz B*, Wang H#, Wong M#. Genetic basis of cell–cell fusion mechanisms. Trends Genet. 2013, 29(7), 427-437. (Invited Review)
  69. Zhou Z, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis. 2013, 4(4), e593.
  70. Zhang Q, Chen Q, Lu XY, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y*, Wang H*. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis. 2013, 4(2), e502. 
  71. Lin HY*, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H*, Hammond GL*. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab. 2012, 97(4), E678-E686.
  72. Zhao KQ, Lin HY*, Zhu C, Yang X, Wang H*. Maternal Smad3 deficiency compromises decidualization in mice. J Cell Biochem. 2012, 113(10), 3266-3275.
  73. Wu L, Zhou H, Lin H, Qi J, Zhu C, Gao Z*, Wang H*. Circulating microRNAs are elevated in plasma from severe pre-eclamptic pregnancies. Reproduction. 2012, 143(3), 389-397.
  74. Yang X, Zhou Y, Peng S, Wu L, Lin HY, Wang S*, Wang H*. Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis. Reproduction. 2012, 144(2), 235-244.
  75. Lin P, Fu J, Zhao B, Lin F, Zou H, Liu L, Zhu C, Wang H*, Yu X*. Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. Mol Biol Rep. 2011, 38(3), 1741–1747. 
  76. Fu J, Lv X, Lin H, Wu L, Wang R, Zhou Z, Zhang B, Wang YL, Tsang BK, Zhu C, Wang H*. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem. 2010, 285(14), 10870-10879.
  77. Zhang B, Zhou Z, Lin H, Lv X, Fu J, Lin P, Zhu C, Wang H*. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. Histochem Cell Biol. 2009, 132(2), 169-179. 
  78. Zhou Z, Shen T, Zhang BH, Lv XY, Lin HY, Zhu C, Xue LQ*, Wang H*. The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion. Placenta. 2009, 30(11), 929-938.
  79. Fu JJ, Lin P, Lv XY, Yan XJ, Wang HX, Zhu C, Tsang BK, Yu XG*, Wang H*. Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion. Placenta, 2009, 30(4), 305-312.
  80. Wang H*, Tsang BK*. Nodal signalling and apoptosis. Reproduction. 2007, 133(5), 847-853.
  81. Zhang X, Zhu C, Lin H, Yang Q, Ou Q, Li Y, Chen Z, Racey P, Zhang S*, Wang H*. Wild fulvous fruit bats (Rousettus leschenaulti) exhibit human-like menstrual cycle. Biol Reprod. 2007, 77(2), 358-364. (Cover Story)
  82. Wang H*, Jiang JY, Zhu C, Peng C, Tsang BK*. Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia. Mol Endocrinol. 2006, 20(10), 2469-82.