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Name:
 HE Hongxuan
Subject:
 Biochemistry and Molecular Biology
Tel/Fax:
 +86-10-64807118  / 
E-mail:
 hehx@ioz.ac.cn
Address:
 Key Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, 1Beichen West Road, Chaoyang District, Beijing 100101, P.R. China
More:
 Group of Wildlife Borne Diseases      
Resume:
EDUCATION
  • Ph.D. (1999 to 2002):  Preventive Veterinary Medicine, Changchun Agriculture and AnimalScienceUniversity, Changchun, P.R. China
  • M. Sc. (1996 - 1998):  Preventive Veterinary Medicine, Changchun Agriculture and AnimalScienceUniversity, Changchun, P.R. China
  • B. Sc. (1989-1993): Animal Science, Dept. of Animal Science and Veterinary, Henan Vocational-technical Teachers College, Xinxiang, Henan Province, P.R. China
EMPOLYMENT HISTORY
  • Professor (January, 2006-present): National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of  Sciences

Research Project:  Surveillance and control of wildlife borne diseases (bird flu).

  • Postdoctoral (Oct, 2004-July, 2005): Population Medicine and Diagnostic Science, VeterinaryCollege, Cornell University, USA.

Research Project:  Development of DNA vaccine and serologic test against leptospirosis.

  • Postdoctoral (January, 2003-October, 2004): Department of Biological Sciences and Biotechnology, TsinghuaUniversity, Beijing, P.R. China.

Research Project:  DNA vaccines of AI, Cryptosporidiosis and SARS.

  • Professor and Associate Dean (2002-present). Department of Preventive Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, Henan Province, P.R. China.

Administrative responsibilities: Teaching, research and administrative activities of the department. Director of special research project in the animal vaccines and medications, swine and chicken farm.

  • Lecturer of Animal Microbiology (1999-2002).  Dept. of Animal Science and Veterinary,

HenanVocational-TechnicalTeachers College, Xinxiang, Henan province
Research Project:  DNA vaccines of AI, Cryptosporidiosis and SARS.
Teaching Responsibilities: Teaching courses in animal parasitology and mocrobiology.

  • Teaching Assistant (1993-1996), Dept. of Animal Science and Veterinary,

HenanVocational-technicalTeachers College, Xinxiang, Henan Province,China.
Responsibilities: Assisted in teaching and research in animal sciences.

Research Interests:

　　Our current researches focus on wildlife-borne zoonosis and diseases harmful to endangered species caused by viruses, bacterium, and parasites, especially avian influenza. We mainly have done lots of work ininvestigating the mechanism of pathogen invasion and pathogenesis, elucidating the rules on diseases progress in organism and transmission among organisms, establishing monitoring system and platform with kinds of detecting methods to meet different demands, developing new control methods that are safer and more protective,conducting epidemiological investigation and tracing origin of diseases, andconstructing rapid and accurate early-warning and risk-assessment systems, and providing scientific basis for animal disease management and decision making. 

Awards and Honors:

Professional Activities:
  • Executive Deputy Director, National Research Center For Wildlife Diseases, Institute of Zoology, Chinese Academy of Sciences and State Forestry Administration
  • Member of expert group in wild animal disease warning and prevention and control, the State Forestry Administration
  • head of China, cooperation network of Asia Pacific wildlifediseases
  • Member of International Association of Wildlife Diseases
  • Member of the Federation of Asian Biotech Associations
  • Member of International Association of Zoology
  • 《Chinese Journal of Vector Biology and Control》Editorial board member
  • 《Integrative Zoology》Editorial board member
  • 《ActaTheriologicaSinica》Editorial board member
  • 《Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases》Guest reviewers
  • 《American Journal of Tropical Medicine & Hygiene》Guest reviewers
  • 《Journal of Helminthology》Guest reviewers
  • 《PloSONE》Guest reviewers

Research Grants:
  • The Ministry Of Science and Technology, the Science & Technology Support Project of The Eleventh-Five-Year Plan Of China (2009BAI83B01).
  • The State Plan for High-Tech Research and Development(863),(2007AA100606)，2007-2010。
  • The State Plan for Development of Basic Research(973),(9732007BC109103)，2007-2012
  • The Ministry of Science and Technology, the Science & Technology Support Project of The Twelfth-Five-Year Plan Of China (2013BAD12B04).
  • National Science Foundation of China (31072126), 2011-2013.
  • National Science Foundation of China (31101806), 2012-2014.
  • The State Forestry Administration, Wild Animal Epidemic Disease Monitoring Project，2014-2015.
  • China Agriculture Research System Poultry-related Science and Technology Innovation Team of Peking (CARS-PSTP).

Selected Publications:
  1. Xing Y, Chen L, Hu B, Li Y, Mai H, Li G, Han S, Wang Y, Huang Y, Tian Y, Zhang W, Gao Y, He H. Therapeutic role of miR-19a/b protection from influenza virus infection in patients with coronary heart disease [J]. Mol Ther Nucleic Acids. 2024, 35(1):102149. doi:10.1016/j.omtn.2024.102149.
  2. Huang Y, Zhang P, Han S, Hu B, Zhang Q, He H. Effect of Enteromorpha polysaccharides on gut-lung axis in mice infected with H5N1 influenza virus [J]. Virology. 2024, 593:110031.
  3. Zhao Z, Han S, Zhang Q, Wang Y, Yue K, Abbas S, He H. Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3 [J]. Virol J. 2024, 21(1):33.
  4. Zhang Q, Zhou Q, Han S, Li Y, Wang Y, He H. The genome of sheep ked (Melophagus ovinus) reveals potential mechanisms underlying reproduction and narrower ecological niches [J]. BMC Genomics, 2023, 24(1): 54.
  5. Zhang H, Han S, Wang B, Xing Y, Yuan G, Wang Y, Zhao Z, Li G, Li Q, Pan J, Li W, He H. Genetic Characterization and Pathogenesis of Avian Influenza Virus H3N8 Isolated from Chinese pond heron in China in 2021 [J]. Viruses, 2023, 15(2).
  6. Xiao X, Zhang Q, Wu S, Li Y, Zhong Z, Guo Q, Li J, Meng Q, Cheng Z, Duan J, Wang X, He H, Bai J, Lou Y. Detection of Clostridium perfringens Using Novel Methods Based on Recombinase-Aided Amplification Assay-Assisted CRISPR/Cas12a System [J]. Transbound Emerg Dis, 2023, 2023: 6667618.
  7. Xiang C, Li Y, Jing S, Han S, He H. Trichomonas gallinae Kills Host Cells Using Trogocytosis [J]. Pathogens, 2023, 12(8).
  8. Wu Q, Wang Y, Zhang X, Gu X, He H, Jin X. Pyogranulomatous dermatitis with Enterococcus faecalis in a spotted seal (Phoca larga) [J]. Vet Med Sci, 2023, 9(2): 985-991.
  9. Wang Z, Sun X, Chen X, Wang H, He H. The Mass Spectrometry Identification, Antimicrobial Genes Detection, and Proteomics Analysis of Stutzerimonas stutzeri Strain Was Isolated from Industrial Wastewater [J]. Separations, 2023, 10(9): 461.
  10. Wang H, Sun C, Chen X, Yan K, He H. Isolation of Pseudomonas oleovorans Carrying Multidrug Resistance Proteins MdtA and MdtB from Wastewater [J]. Molecules, 2023, 28(14).
  11. Wang H, Guo J, Chen X, He H. The Metabolomics Changes in Luria-Bertani Broth Medium under Different Sterilization Methods and Their Effects on Bacillus Growth [J]. Metabolites, 2023, 13(8).
  12. Wang B, Huang Y, Hu B, Zhang H, Han S, Yang Z, Su Q, He H. Characterization of a reassortant H11N9 subtype avian influenza virus isolated from spot-billed duck in China [J]. Virus Genes, 2023, 59(4): 604-612.
  13. Su Q, Chen Y, He H. Molecular evolution of Toll-like receptors in rodents [J]. Integr Zool, 2023.
  14. Li G, Zhang T, Hu B, Han S, Xiang C, Yuan G, He H. Infection with Cryptosporidium parvum Affects Secondary Sexual Characteristics of Male Mice by Altering the Pheromone Content in Preputial Gland [J]. Animals (Basel), 2023, 13(4).
  15. Li G, Zhang T, Hu B, Han S, Xiang C, Yuan G, He H. Infection of Trichinella spiralis Affects the Reproductive Capacity of ICR/CD-1 Male Mice by Reducing the Urine Pheromone Contents and Sperm Quality [J]. Int J Mol Sci, 2023, 24(6).
  16. Li G, Wang Q, Zhang M, Hu B, Han S, Xiang C, Yuan G, He H. Male-Biased Parasitism of Brandt's Voles (Lasiopodomys brandtii) in Inner Mongolia, China [J]. Animals (Basel), 2023, 13(8).
  17. Jing S, Zhang Q, Li Y, Chang H, Xiang C, Han S, Yuan G, Fan J, He H. Identification of new drug candidates against Trichomonas gallinae using high-throughput screening [J]. Int J Parasitol Drugs Drug Resist, 2023, 23: 19-27.
  18. Huang Y, Zhang P, Han S, He H. Lactoferrin Alleviates Inflammation and Regulates Gut Microbiota Composition in H5N1-Infected Mice [J]. Nutrients, 2023, 15(15).
  19. Hu B, Wang J, Li Y, Ge J, Pan J, Li G, He Y, Zhong H, Wang B, Huang Y, Han S, Xing Y, He H. Gut microbiota facilitates adaptation of the plateau zokor (Myospalax baileyi) to the plateau living environment [J]. Front Microbiol, 2023, 14: 1136845.
  20. Hu B, Han S, He H. Effect of epidemic diseases on wild animal conservation [J]. Integr Zool, 2023, 18(6): 963-980.
  21. Zhang X, Cui K, Wen X, Li L, Yu X, Li B, Lin H, He H, Wang F. The Association between Gut Microbiome Diversity and Composition and Heat Tolerance in Cattle [J]. Microorganisms, 2022, 10(8).
  22. Zhang Q, Zhong Z, Xia Z, Meng Q, Shan Y, Guo Q, Cheng Z, Zhang P, He H, Bai J. Molecular Epidemiology and Genetic Diversity of Enterocytozoon bieneusi in Cervids from Milu Park in Beijing, China [J]. Animals (Basel), 2022, 12(12).
  23. Zhang P, Zhang Q, Han S, Yuan G, Bai J, He H. Occurrence and Genetic Diversity of the Zoonotic Enteric Protozoans and Enterocytozoon bieneusi in Père David's Deer (Elaphurus davidianus) from Beijing, China [J]. Pathogens, 2022, 11(11).
  24. Zhang P, Feng S, Jia T, Han S, Zhang C, He H. Prevalence and genetic diversity of Enterocytozoon bieneusi in nonhuman primates in Northern and Central China [J]. Int J Parasitol Parasites Wildl, 2022, 17: 273-277.
  25. Wu Q, Chen L, Zhang Q, Jin X, Tang L, Zhang X, Liu Y, Li J, Pei J, Zhu Q, Jin S, Zhao Q, Shen J, Zhao Z, Jin Y, He H, Gu X, Yang M. Sarcoptic mange is an emerging threat to biodiversity in the Qinling Mountains in China [J]. Transbound Emerg Dis, 2022, 69(6): 3724-3736.
  26. Wang H, He H. Detection of Drug-Resistant Kluyvera intermedia from Zoacys dhumnades [J]. Cell Mol Biol (Noisy-le-grand), 2022, 68(9): 97-101.
  27. Su Q, Chen Y, Wang B, Zhang Q, He H. Genetic characterizations of Toll-like receptors in the brown rat and their associations with pathogen infections [J]. Integr Zool, 2022, 17(5): 879-889.
  28. Ren Z, Okyere S K, Zhang M, Zhang X, He H, Hu Y. Glycine Nano-Selenium Enhances Immunoglobulin and Cytokine Production in Mice Immunized with H9N2 Avian Influenza Virus Vaccine [J]. Int J Mol Sci, 2022, 23(14).
  29. Hu B, Wang J, Zhang S, Wang B, Xing Y, Han S, He H. Novel genotypes of Cryptosporidium and Enterocytozoon bieneusi detected in plateau zokors (Myospalax baileyi) from the Tibetan Plateau [J]. Int J Parasitol Parasites Wildl, 2022, 19: 263-268.
  30. Zhang Q X, Wang Y, Li Y, Han S Y, Wang B, Yuan G H, Zhang P Y, Yang Z W, Wang S L, Chen J Y, Zhong H S, Han X Q, He H X. Vector-Borne Pathogens with Veterinary and Public Health Significance in Melophagus ovinus (Sheep Ked) from the Qinghai-Tibet Plateau [J]. Pathogens, 2021, 10(2).
  31. Zhang Q, Meng M, Huang C, Feng S, Liu J, Tang Y, Fan Y, Yuan G, Han S, Luo J, Zhao B, He H. Identification and genetic characterization of Contracaecum sp. (Nematoda: Anisakidae) from China [J]. Integr Zool, 2021, 16(6): 929-938.
  32. Zhang Q, Liu J, Han S, Wang B, Su Q, Yuan G, He H. Genetic and evolutionary characterization of avian paramyxovirus type 4 in China [J]. Infect Genet Evol, 2021, 91: 104777.
  33. Wang Y, Zhang Q, Han S, Li Y, Wang B, Yuan G, Zhang P, Yang Z, Zhang H, Sun Y, Chen J, Han X, He H. Ehrlichia chaffeensis and Four Anaplasma Species With Veterinary and Public Health Significance Identified in Tibetan Sheep (Ovis aries) and Yaks (Bos grunniens) in Qinghai, China [J]. Front Vet Sci, 2021, 8: 727166.
  34. Wang Y, Wang B, Zhang Q, Li Y, Yang Z, Han S, Yuan G, Wang S, He H. The Common Occurrence of Theileria ovis in Tibetan Sheep and the First Report of Theileria sinensis in Yaks from Southern Qinghai, China [J]. Acta Parasitol, 2021, 66(4): 1177-1185.
  35. Wang B, Su Q, Luo J, Li M, Wu Q, Chang H, Du J, Huang C, Ma J, Han S, Yuan G, He Y, Guo M, Zhang Q, He H. Differences in Highly Pathogenic H5N6 Avian Influenza Viral Pathogenicity and Inflammatory Response in Chickens and Ducks [J]. Front Microbiol, 2021, 12: 593202.
  36. He Y C, Li J X, Sun Y L, Kang M, He H X, Guo Y H, Ma P, Wei Y P, Li R S, Chen W K, Chen Z H, Li J, Qi T S, Yang J F, Zhang Q X, Wang Y, Cai J S, Zhao Q B, Hu G W, Chen J Y, Li Y. Spotted Fever Group Rickettsia Infecting Ticks (Acari: Ixodidae), Yak (Bos grunniens), and Tibetan Sheep (Ovis aries) in the Qinghai-Tibetan Plateau Area, China [J]. Front Vet Sci, 2021, 8: 779387.
  37. Feng S, Chang H, Wang Y, Luo F, Wu Q, Han S, He H. Lethal infection caused by Tetratrichomonas gallinarum in black swans (Cygnus atratus) [J]. BMC Vet Res, 2021, 17(1): 191.
  38. Zhang Q, Luo D, Xie Z, He H, Duan Z. The Oncogenic Role of miR-BART19-3p in Epstein-Barr Virus-Associated Diseases [J]. Biomed Res Int, 2020, 2020: 5217039.
  39. Wang H, Guo J, Zheng L, Liu S, Wang Z, He H. Detection of new antibiotic resistance gene profile in Escherichia coli associated with avian leukosis virus infection from broiler chickens [J]. BIOCELL, 2020, 44(2).
  40. Su Q, Chen Y, Wang B, Huang C, Han S, Yuan G, Zhang Q, He H. Epidemiology and genetic diversity of zoonotic pathogens in urban rats (Rattus spp.) from a subtropical city, Guangzhou, southern China [J]. Zoonoses Public Health, 2020, 67(5): 534-545.
  41. Feng S, Jia T, Huang J, Fan Y, Chang H, Han S, Luo J, He H. Identification of Enterocytozoon bieneusi and Cryptosporidium spp. in farmed wild boars (Sus scrofa) in Beijing, China [J]. Infect Genet Evol, 2020, 80: 104231.
  42. Feng S, Chang H, Wang Y, Huang C, Han S, He H. Molecular Characterization of Cryptosporidium spp. in Brandt's Vole in China [J]. Front Vet Sci, 2020, 7: 300.
  43. Chang H, Feng S, Wang Y, Li F, Su Q, Wang B, Du J, He H. Isolation and Pathogenic Characterization of Pigeon Paramyxovirus Type 1 via Different Inoculation Routes in Pigeons [J]. Front Vet Sci, 2020, 7: 569901.
  44. Zhang Q, Liu K, Wang C, Luo J, Lu J, He H. Molecular Characterization of Entamoeba spp. in Wild Taihangshan Macaques (Macaca mulatta tcheliensis) in China [J]. Acta Parasitol, 2019, 64(2): 228-231.
  45. Zhang Q, Han S, Liu K, Luo J, Lu J, He H. Occurrence of Selected Zoonotic Fecal Pathogens and First Molecular Identification of Hafnia paralvei in Wild Taihangshan Macaques (Macaca mulatta tcheliensis) in China [J]. Biomed Res Int, 2019, 2019: 2494913.
  46. Wang H, Chen L, Luo J, He H. NP and NS1 proteins of H5N1 virus significantly upregulated IFITM1, IFITM2, and IFITM3 in A549 cells [J]. Afr Health Sci, 2019, 19(1): 1402-1410.
  47. Su Q, Chen Y, Li M, Ma J, Wang B, Luo J, He H. Genetic Characterization and Molecular Evolution of Urban Seoul Virus in Southern China [J]. Viruses, 2019, 11(12).
  48. Meng W, Yang Q, Vrancken B, Chen Z, Liu D, Chen L, Zhao X, Francois S, Ma T, Gao R, Ru W, Li Y, He H, Zhang G, Tian H, Lu J. New evidence for the east-west spread of the highly pathogenic avian influenza H5N1 virus between Central Asian and east Asian-Australasian flyways in China [J]. Emerg Microbes Infect, 2019, 8(1): 823-826.
  49. Li M, Feng S, Lv S, Luo J, Guo J, Sun J, He H. Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China [J]. Emerg Microbes Infect, 2019, 8(1): 377-380.
  50. Feng S Y, Chang H, Luo J, Huang J J, He H X. First report of Enterocytozoon bieneusi and Cryptosporidium spp. in peafowl (Pavo cristatus) in China [J]. Int J Parasitol Parasites Wildl, 2019, 9: 1-6.
  51. Du J, Luo J, Huang J, Wang C, Li M, Wang B, Wang B, Chang H, Ji J, Sen K, He H. Emergence of Genetic Diversity and Multi-Drug Resistant Campylobacter jejuni From Wild Birds in Beijing, China [J]. Front Microbiol, 2019, 10: 2433.