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Name:
 LIU Changmei
Subject:
 Regenerative Medicine
Tel/Fax:
 +86-10-82619690  / 
E-mail:
 liuchm@ioz.ac.cn
Address:
 The State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
 Group of Stem Cell and Neurological Diseases      
Resume:

2014-present:  Professor, Institute of Zoology, Chinese Academy of Sciences

2011-2014:  Johns Hopkins University School of Medicine, Postdoctoral Fellow

2008- 2011:  University of New Mexico School of Medicine, Postdoctoral Fellow

2004- 2008:  Chinese Academy of Sciences Institute of Microbiology, Assistant/Associate Researcher

2001- 2004:  Peking Union Medical College, Ph.D.

Research Interests:

The research group explore therapeutic approaches for neurological diseases, with a focus on neurodevelopmental disorders, neural injuries, and neurodegenerative diseases. It aims to uncover the pathogenic mechanisms and to investigate the regulatory mechanisms governing the self-renewal and differentiation of neural stem cells, while exploring their therapeutic potential. Building on this foundation, the group is committed to developing novel cell-based and small-molecule drugs for neurological disorders and establishing innovative stem cell-based treatment strategies for neurological diseases.

Awards and Honors:

Professional Activities:

Research Grants:
  • 2015-2018, Institute of Zoology, Chinese Academy of Sciences, PI.
  • 2016-2019, “Functions of H3K27 De-methylation in Neuronal Maturation and Cognition”, National Basic Research Program of China, PI.
  • 2018-2021, “The Function and Mechanism of Chromatin Remodeling Gene ARID1A in the Development of Hippocampus and Intelligence in Mice”, National Basic Research Program of China, PI
  • 2018-2020, “The Roles and Mechanism of H3K27me3 and Associated Demethylase UTX/JMJD3 in Optic Nerve Regeneration and Vision Restoration”, National Basic Research Program of China, PI.
  • 2016-2020, “Stem Cell Models and Targeted Gene Editing Therapy for Neurological Disorders in Primates”, National Key Research and Development Program of China Project, PI.
  • 2018-2022, "Mechanisms of Hippocampal Neuroregeneration After Traumatic Brain Injury and Improvement of Cognitive Function", Subproject of the Strategic Priority Research Program of the Chinese Academy of Sciences,PI.
  • 2021-2026, “Mechanisms and Intervention of Immune Microenvironment in Neurodegenerative Diseases on Neural Regeneration”, National Key Research and Development Program of China Project, PI.
  • 2023-2026, "Role and Application of the DGCR8/MicroRNA Axis in Regulating Damage Repair of Retinal Ganglion Cells", National Basic Research Program of China, PI.

Selected Publications:
  1. Liu PP*, Han X*, Li X*, Dai SK, Xu YJ, Jiao LF, Du HZ, Zhao LH, Li RF#, Teng ZQ#, Yang YG#, Liu CM#. An EED/PRC2-H19 Loop Regulates Cerebellar Development. Adv Sci (Weinh). 2025 Jan;12(1):e2403591. （通讯，IF: 14.3）
  2. Liu C*, Shao FH*, He XC*, Du HZ, Liu CM#, Zhou B#, Teng ZQ#. Single-Cell RNA Sequencing Uncovers Molecular Features Underlying the Disrupted Neurogenesis Following Traumatic Brain Injury. Glia. 2025 Jan 6. doi: 10.1002/glia.24671. （通讯，IF: 5.4）
  3. Cong H*, Wang J*, Du N*, Song L, Wang R, Yang Y, Lei R, Tang TS#, Liu CM#, Zhu S#, Han X*#. ITGB4/CD104 mediates zika virus attachment and infection. Nat Commun. 2024 Dec 30;15(1):10729. （通讯，IF: 14.7）
  4. Li CP*, Wu S*, Sun YQ, Peng XQ, Gong M, Du HZ, Zhang J, Teng ZQ#, Wang N#, Liu CM#. Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma. Cell Rep Med. 2024 May 21;5(5):101554. （通讯，IF: 11.7）
  5. Peng XQ*, Li YZ*, Gu C, He XC, Li CP, Sun YQ, Du HZ, Teng ZQ#, Liu CM#. Marcks overexpression in retinal ganglion cells promotes optic nerve regeneration. Cell Death Dis. 2024 Dec 18;15(12):906. （通讯，IF: 8.1）
  6. Gong M*, Li J*, Qin Z*, Machado Bressan Wilke MV*, Liu Y, Li Q, Liu H, Liang C, Morales-Rosado JA, Cohen ASA, Hughes SS, Sullivan BR, Waddell V, van den Boogaard MH, van Jaarsveld RH, van Binsbergen E, van Gassen KL, Wang T, Hiatt SM, Amaral MD, Kelley WV, Zhao J, Feng W, Ren C, Yu Y, Boczek NJ, Ferber MJ, Lahner C, Elliott S, Ruan Y, Mignot C, Keren B, Xie H, Wang X, Popp B, Zweier C, Piard J, Coubes C, Mau-Them FT, Safraou H, Innes AM, Gauthier J, Michaud JL, Koboldt DC, Sylvie O, Willems M, Tan WH, Cogne B, Rieubland C, Braun D, McLean SD, Platzer K, Zacher P, Oppermann H, Evenepoel L, Blanc P, El Khattabi L, Haque N, Dsouza NR, Zimmermann MT, Urrutia R, Klee EW, Shen Y, Du H, Rappaport L, Liu CM#, Chen X#. MARK2 variants cause autism spectrum disorder via the downregulation of WNT/beta-catenin signaling pathway. Am J Hum Genet. 2024;111(11):2392-2410. （通讯，IF: 8.1）
  7. Ke JP, He BD, Gong ML, Yan ZZ, Du HZ, Teng ZQ#, Liu CM#. Loss of microglial Arid1a exacerbates microglial scar formation via elevated CCL5 after traumatic brain injury. Cell Commun Signal. 2024;22(1):467. （通讯，IF: 8.2）
  8. Shen SJ, Liu CM#. Chemotherapy for early-stage breast cancer: the more the better? Lancet. 2023 Apr 15;401(10384):1243-1245. （通讯，IF: 98.4）
  9. Wang XW, Yang SG, Hu MW, Wang RY, Zhang C, Kosanam AR, Ochuba AJ, Jiang JJ, Luo X, Guan Y, Qian J, Liu CM#, Zhou FQ#. Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways. J Clin Invest. 2023 Nov 28;134(3):e163145. （通讯，IF: 13.3）
  10. Liu PP*, Lu SP*, Li X, Tang GB, Liu X, Dai SK, Jiao LF, Lin XW, Li XG, Hu B, Jiao J, Teng ZQ#, Liu CM#. Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus. Cell Death Differ. 2023 Sep;30(9):2187-2199. （通讯，IF: 13.7）
  11. Xu YJ, Dai SK, Duan CH, Zhang ZH, Liu PP, Liu C, Du HZ, Lu XK, Hu S, Li L, Teng ZQ#, Liu CM#. ASH2L regulates postnatal neurogenesis through Onecut2-mediated inhibition of TGF-β signaling pathway. Cell Death Differ. 2023 Aug;30(8):1943-1956. （通讯，IF: 13.7）
  12. Xu YJ, Liu PP, Yan ZZ, Mi TW, Wang YY, Li Q, Teng ZQ#, Liu CM#. KW-2449 and VPA exert therapeutic effects on human neurons and cerebral organoids derived from MECP2-null hESCs. Stem Cell Res Ther. 2022 Dec 27;13(1):534. （通讯，IF: 8.0）
  13. Zhang SF, Dai SK, Du HZ, Wang H, Li XG, Tang Y#, Liu CM#. The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis. Stem Cell Reports. 2022 Sep 13;17(9):2064-2080. （通讯，IF: 5.9）
  14. Liu PP*, Dai SK*, Mi TW*, Tang GB, Wang Z, Wang H, Du HZ, Tang Y#, Teng ZQ#, Liu CM#. Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Mol Med. 2022 Dec 7;14(12):e15795. （通讯，IF: 11.4）
  15. Gong M, Shi R, Liu Y, Ke J, Liu X, Du HZ, Liu CM#.Abnormal microglial polarization induced by Arid1a deletion leads to neuronal differentiation deficits. Cell Prolif. 2022 Nov;55(11):e13314. （通讯，IF: 8.5）
  16. Dai SK, Liu PP, Li X, Jiao LF, Teng ZQ#, Liu CM#. Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development. Development. 2022 Jul 15;149(14):dev200049. （通讯，IF: 4.6）
  17. Dai SK, Liu PP, Du HZ, Liu X, Xu YJ, Liu C, Wang YY, Teng ZQ#, Liu CM#. Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters. EMBO Rep. 2021 Oct 5;22(10):e52023. （通讯，IF: 9.071）
  18. Liu X, Dai SK, Liu PP, Liu CM#. Arid1a regulates neural stem/progenitor cell proliferation and differentiation during cortical development. Cell Prolif. 2021 Nov;54(11):e13124. （通讯，IF: 8.755）
  19. Liu C*, Dai SK*, Shi RX, He XC, Wang YY, He BD, Sun XW, Du HZ, Liu CM#, Teng ZQ#.Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration. Glia. 2021 May;69(5):1292-1306. （通讯，IF: 8.073）
  20. Peng XQ, Dai SK, Li CP, Liu PP, Wang ZM, Du HZ, Teng ZQ, Yang SG, Liu CM#.Loss of Arid1a Promotes Neuronal Survival Following Optic Nerve Injury.Front Cell Neurosci.2020;14:131.（通讯，IF: 5.505）
  21. Tang QY, Zhang SF, Dai SK, Liu C, Wang YY, Du HZ, Teng ZQ#, Liu CM#.UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters.Stem Cell Reports.2020 Aug 11;15(2):439-453.（通讯，IF: 7.765）
  22. Xu YJ*, Liu PP*, Ng SC, Teng ZQ, Liu CM#.Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system.J Mol Cell Biol.2020 Jun 11;12(5):327-336.（通讯，IF: 6.216）
  23. Liu PP*, Xu YJ*, Dai SK, Du HZ, Wang YY, Li XG, Teng ZQ#, Liu CM#. Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus. Stem Cell Reports. 2019 Jul 9;13(1):115-131.（通讯，IF: 6.032）
  24. Duan RS*, Tang GB*, Du HZ*, Hu YW, Liu PP, Xu YJ, Zeng YQ, Zhang SF, Wang RY, Teng ZQ, Liu CM#. Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration. Cell Death Differ. 2018 Sep;25(9):1598-1611.（通讯，IF: 8.086）
  25. Liu PP, Xu YJ, Teng ZQ, Liu CM#. Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System. Neuroscientist. 2018 Jun;24(3):208-220.（通讯，IF: 6.791）
  26. Liu PP, Tang GB, Xu YJ, Zeng YQ, Zhang SF, Du HZ, Teng ZQ#, Liu CM#. MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells. Stem Cell Reports. 2017 Jul 11;9(1):190-202.（通讯，IF: 6.537）
  27. Jiang JJ*, Liu CM*, Zhang BY, Wang XW, Zhang M, Saijilafu, Zhang SR, Hall P, Hu YW, Zhou FQ#. MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression. Cell Death and Disease. 2015, 6: e1865.（一作，IF: 5.378）
  28. Liu CM*, Wang RY*, Saijilafu, Jiao ZX, Zhang BY, Zhou FQ#. MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. Genes Dev. 2013, 27(13):1473-83. （一作，IF: 12.639）
  29. Liu CM, Hur EM, Zhou FQ#. Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling. Front Mol Neurosci. 2012 Feb 6;5:3. （一作，IF:N/A）
  30. Liu CM*, Teng ZQ*, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X#. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell 2010, 6(5): 433-44.（一作，IF: 25.943）