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Name:
 Qiutan Yang
Subject:
 Developmental Biology
Tel/Fax:
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E-mail:
 qiutan.yang@ioz.ac.cn
Address:
 The State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences,1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
 Constructing epithelial organoid system      
Resume:

03.2023-Present, Professor, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, CAS, Beijing, China.

08.2017-12.2022, Postdoctoral researcher, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

07.2016-07.2017, Postdoctoral researcher, University of Zurich, Zurich, Switzerland.

11.2011-06.2016, Ph. D., University of Zurich, Zurich, Switzerland.

10.2010-08.2011, Exchange student, University of Zurich, Zurich, Switzerland.

06.2009-09.2010, Guest student, Kunming Institute of Zoology, CAS, Kunming, China.

09.2008-06.2011, M. S., West China Hospital, Sichuan University, Chengdu, China

09.2004-06.2008, B. S., Sichuan Normal University, Chengdu, China

Research Interests:

Three-Dimensional culture of human/mammalian adult, embryonic or induced prepotent stem cells could lead to the formation of organoid, which contains both the stem-cell enriched region and the differentiated tissue.  

Using the epithelial organoid systems, we preform large-scale imaging acquisition and analysis, and dissect the mechanobiology as well as cellular and molecular events in the multicellular systems. Eventually, we refer the multi-scale mechanisms to construct in vitro disease models and endow the tissues/organs with proper physiological functions.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Shi-Lei Xue*, Qiutan Yang*, Prisca Liberali#, Edouard Hannwzo#. Mechanochemical bistability of intestinal organoids enables robust morphogenesis. Nature Physics 2025; 21:pages608–617.
  2. Berkova L, Fazilaty H, Yang Q, Kubovciak J, Stastna M, Hrckulak D, Vojtchova M, Brugger M, Hausmann G, Liberali P, Korinek V, Basler K, Valenta T. Terminal differentiation of villus tip enterocytes is governed by distinct Tgfb superfamily members. EMBO reports 2023, 24(9): e56454. DOI: 10.15252/embr.202256454
  3. Yang Q*#, Xue SL*, Chan JC, Rempfler M, Vischi D, Mauer F, Hiiragi T, Hannezo E#, Liberali P#. Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. Nature Cell Biology, 2021; 23(7):733-744. （Cover article ）
  4. Yang Q, Roiz D, Mereu L, Daube M, Hajnal A. Sequential apical and lateral cell constrictions initiate vulval lumen formation in C. elegans. Developmental Cell 2017; 42(3): 271-285.
  5. Yang Q, Lv X, Kong Q, Li C, Zhou Q, Mao B. Dynamic expression of the LAP family of genes during early development of Xenopus tropicalis. Sci China Life Sci 2011; 54(10): 897-903. 
  6. Haag A*, Gutierrez P*, Buuhler A*, Walser M, Yang Q, Langouet M, Kradolfer D, Frohli E, Herrmann CJ, Hajnal A, et al. An in vivo EGF receptor localization screen in C. elegans identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. PLoS Genet 2014; 10(5): e1004341.
  7. Ma P, Zhao S, Zeng W, Yang Q, Li C, Lv X, Zhou Q, Mao B. Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning. Biochem Biophys Res Commun 2011; 19;412(1): 170-4. 

Review and comments：

  1. Yang Q, Liberali P. Adaptive differentiation for fast barrier restoration. Developmental Cell, 2022; 57(2): 147-148.
  2. Yang Q, Liberali P. Collective behavior in organoids. Current Opinion in Cell Biology, 2021;72:81-90.
  3. Yang Q*, Oost KC*, Liberali P. Engineering human knock-in organoids. Nature Cell Biology, 2020; 22(3): 261-263.