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Name:
 Du Lei
Subject:
 Molecular biology
Tel/Fax:
 +86-10-64807322  /  +86-10-64807322
E-mail:
 dul@ioz.ac.cn
Address:
 The State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences,Beichen West Road 1#-5, Chaoyang District, Beijing, China
More:
 Group of Molecular and Cellular Neuroscience      
Resume:

2014-present Associate Professor, The State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences.

2007-2014 Assistant Professor, The State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences.

2002- 2007 Ph.D. Cellular Biology, Institute of Zoology, Chinese Academy of Sciences.

1998- 2002 Bachelor degree of Life Science. Wuhan University, Hubei, China.

Research Interests:
cancer stem cell

Awards and Honors:

Professional Activities:

Research Grants:

National Key Research and Development Project (2016-2021). Sub-project Leader

National Natural Science Foundation of China (2014-2017): Molecular mechanism of cellular prion protein induced cancer metastasis. Project Leader

National Natural Science Foundation of China (2010-2013): Mechanism of PTO induced cancer stem cell death. Project Leader;

Selected Publications:
  1. Du L, Rao G, Wang H, Li B, Tian W, Cui JT, He L, Laffin B, Tian X, Hao C, Liu H, Sun X, Zhu Y, Tang DG, Mehrpour M, Lu Y*, Chen Q*. CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer, Cancer Research, 73(8): 2682-2694, 2013.
  2. Rao GH#, Liu HM#, Li BW, Hao JJ, Yang YL, Wang MR, Wang XH, Wang J, Jin HJ, Du L*, Chen Q *. Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs. Acta Pharmacologica Sinica ,34(6): 793–804, 2013.(Co-corresponding author)
  3. Rao G, Wang H, Li B, Huang L, Xue D, Wang X, Jin H, Wang J, Zhu Y, Lu Y, Du L*, Chen Q*. Reciprocal interactions between tumor-associated macrophages and CD44-Positive cancer cells via Osteopontin/CD44 promote tumorigenicity in colorectal cancer. Clin Cancer Res. 19(4):785-97, 2013. (Co-corresponding author)
  4. Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y*, Chen Q*. CD44 is of functional importance for colorectal cancer stem cell. Clinical Cancer research, 14(21), 6751-6760, 2008.
  5. Liu D, Du L, Chen D, Ye Z, Duan H, Tu T, Feng J, Yang Y, Chen Q, Yan X*. Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signalling. Oncotarge, 7(26):40704-40718, 2016.