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Name:
 Meng Fanwei
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807933  / 
E-mail:
 mengfw@ioz.ac.cn
Address:
 Room A713, Institute of Zoology, Chinese Academy of Siences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
 Fish Evolution and Genomics Group      
Resume:
  • 2016.12-present, Associate professor, Institute of Zoology, Chinese Academy of Sciences
  • 2012.6-2016.12, assistant professor, Institute of Zoology, Chinese Academy of Sciences
  • 2008.7-2012.6, Postdoctoral training in Evolutionary developmental biology, Institute of Zoology, Chinese Academy of Sciences
  • 2003.9-2008.7, Ph.D. in Developmental biology, Department of Biological Sciences and Biotechnology, Tsinghua University
  • 2000.9-2003.7, M.S. in Biochemistry and Molecular Biology, Jilin University
  • 1994.9-1998.7, B.S. in Biochemistry and Molecular Biology, Jilin University

    • Research Grants:

  • 2023-2025, the Third Xinjiang Scientific Expedition Program
  • 2019-2022, National Natural Science Foundation of China
  • 2014-2017, National Natural Science Foundation of China
  • 2011-2015, National Program on Key Basic Research Project
  • 2006,01-12, Youth Program of National Natural Science Foundation of China
    		•

    Research Interests:

    Cave habitats are characterized by perpetual darkness and food scarcity. Cavefish have evolved a suite of phenotypes to cope with the cave environment. The genus Sinocyclocheilus, which is endemic to China, show astonishing diversity of adaptive features. We use zebrafish and Sinocyclocheilus cavefish as model animals, high-throughput sequencing and classical developmental biology experimental techniques as methods to resolve biological puzzles.

    Awards and Honors:

    Professional Activities:

    Research Grants:

    Selected Publications:
    1. Lam SM, Li J, Sun H, Mao W, Lu Z, Zhao Q, Han C, Gong C, Jiang B, Chua GH, Zhao Z, Meng F*#, and Shui G*#. Quantitative Lipidomics and Spatial MS-Imaging Uncovered Neurological and Systemic Lipid Metabolic Pathways Underlying Troglomorphic Adaptations in Cave-Dwelling Fish. Mol Biol Evol 2022, 39(4): msac050.
    2. Zhao Y, Huang Z, Huang J, Zhang C, Meng F*. 2020. Phylogenetic analysis and expression differences of eye-related genes in cavefish genus Sinocyclocheilus. Integr Zool 2021 May;16(3):354-367
    3. Huang Z, Titus T, Postlethwait JH*, Meng F*. 2019. Eye Degeneration and Loss of otx5b Expression in the Cavefish Sinocyclocheilus tileihornes. J Mol Evol 87:199-208.
    4. Meng F*, Zhao Y, Titus T, Zhang C, Postlethwait JH*. 2018. Brain of the blind: transcriptomics of the golden-line cavefish brain. Curr Zool 64:765-773.
    5. Meng F, Braasch I, Phillips JB, Lin X, Titus T, Zhang C, Postlethwait JH. 2013. Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish. Mol Biol Evol 30:1527-1543.
    6. Meng F, Zhao Y, Postlethwait JH, Zhang C. 2013. Differentially-expressed opsin genes identified in Sinocyclocheilus cavefish endemic to China. Curr Zool 59:170-174.
    7. Li F, Lan Y, Wang Y, Wang J, Yang G, Meng F, Han H, Meng A, Wang Y, Yang X. 2011. Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell 20:291-302.
    8. Meng F, Cheng X, Yang L, Hou N, Yang X, Meng A. 2008. Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGFbeta signaling. J Cell Sci 121:2904-2912.
    9. Meng F, Meng A. 2008. Dapper family members modulate distinct signaling pathways in vertebrate development. Trends in Developmental Biology 1(3):61-69
    10. Meng F#, Shi L#, Cheng X, Hou N, Wang Y, Teng Y, Meng A, Yang X. 2007. Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice. Matrix Biol 26:54-57.
    11. Zhang C, Meng F, Wang C, Guo H, Fan M, Liu S, Zhou R, He F. 2004. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. Brain Res Mol Brain Res 130:68-80.
    12. Meng F, Guo H, Zhou R, Zhang C. 2004. Expression and distribution of β-Netrin mRNA in the brain of adult rat. Chinese Journal of Neuroscience, Vol.20 No.4, P286-289.

    *Corresponding author; #Equal contribution