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Name:
 Jie Hao
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-62558737  / 
E-mail:
 haojie@ioz.ac.cn
Address:
 1.The State Key Laboratory of Stem Cell and Reproductive Biology, IOZ, 1 Beichen West Road, Chaoyang District, Beijing, 100101, P.R. China
2.The National Stem Cell Resource Center, 25-2 North 4th Ring West, Haidian District, Beijing, 100190, P.R. China
More:
 Group of Reproductive Engineering      
Resume:

Jie Hao, female, PhD, associate professor, executive director of the National Stem Cell Resource Center, ISO / TC 276 registered expert, member of Professional Committee of Biological Sample Bank of China National Accreditation Service for Conformity Assessment (CNAS)，expert of Standard Working Committee of China Society of Cell Biology, expert and secretary general of Standard Working Group of Chinese Society for Stem Cell Research, member of Youth Innovation Promotion Association of Chinese Academy of Sciences.
Jie Hao is committed to the research of stem cell reproductive medicine, insists on exploring the research of drug route of stem cell medicine, and pays attention to the key scientific issues in the process of stem cell medicine. Independent developed CAStem cell injection was selected the COVID-19 "Three Drug Three Schemes" recommended by the State Council Defense Joint Control Mechanism Key Technology Research Group. The COVID-19 clinical trial of the first international stem cell therapy for pneumonia was successfully launched. Clinical trials and clinical registration tests conducted by the National Drug Administration were actively carried out. It took the lead in establishing the first clinical stem cell bank in China, successfully obtained the approval of the Ministry of Science and Technology and the Ministry of Finance on the national science and technology resource sharing platform to become the National Stem Cell Resource Center, and became the first biological sample bank in China to pass the on-site evaluation of CNAS biological sample bank quality and capacity accreditation criteria and the stem cell bank to obtain the administrative license for human genetic resources in China. Organized the drafting of relevant technical standards in domestic and abroad. Established the National Stem Cell Resource Center Innovation Alliance and actively promote the International Stem Cell Banking Initiative plan (ISCBI).

Research Interests:
Stem cell drug development and clinical application

Awards and Honors:

Professional Activities:

Research Grants:

CAS Strategic Leading Science and Technology Project (a), National Key R & D Plan, CAS Key Deployment Projects, etc.

Selected Publications:
  1. Wu J#, Song D#, Li Z#, Guo B#, Xiao Y, Liu W, Liang L, Feng C, Gao T, Chen Y, Li Y, Wang Z, Wen J, Yang S, Liu P, Wang L, Wang Y, Peng L, Stacey GN, Hu Z, Feng G, Li W, Huo Y, Jin R, Shyh-Chang  N, Zhou Q, Wang L*, Hu B, Dai H*, Hao J*. Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis. Cell Research. Accepted.
  2. Xing D, Wu J, Wang B, Liu W, Liu W, Zhao Y, Wang L, Li JJ, Liu A, Zhou Q, Hao J*, Lin J*. Intra-articular delivery of umbilical cord-derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model. Int J Rheum Dis. 2020 Apr 21.
  3. Li Z#, Wu J#, Wang L#, Han W, Yu J, Liu X, Wang Y, Zhang Y, Feng G, Li W, Stacey GN, Gu Q, Hu B, Wang L, Zhou Q*, Hao J*. Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. Cell Death Dis. 2019 Oct 10;10(10):763.
  4. Wang L#, Wu W#, Gu Q#, Liu Z, Li Q, Li Z, Fang J, Liu W, Wu J, Zhang Y, Wang L, Xu H, Li W, Hu B, Zhou Q*, Yin Z*, Hao J*. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. Protein Cell. 2019 Jun;10(6):455-460.
  5. Ma J#, Wu J#, Han L, Jiang X, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic membrane, umbilical cord and chorionic plate under serum-free condition. Stem Cell Res Ther. 2019 Jan 11;10(1):19.
  6. Li X#, Ma R#, Gu Q#, Liang L, Wang L, Zhang Y, Wang X, Liu X, Li Z, Fang J, Wu J, Wang Y, Li W, Hu B, Wang L*, Zhou Q*, Hao J*. A fully defined static suspension culture system for large-scale human embryonic stem cell production. Cell Death Dis. 2018 Sep; 9(9): 892.
  7. Cao Y#, Sun H#, Zhu H#, Zhu X, Tang X, Yan G, Wang J, Bai D, Wang J, Wang L, Zhou Q, Wang H, Dai C, Ding L, Xu B, Zhou Y, Hao J*, Dai J*, Hu Y*. Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther. 2018 Jul 11; 9(1): 192.
  8. Tan Y#, Han P#, Gu Q#, Chen G, Wang L, Ma R, Wu J, Feng C, Zhang Y, Wang L, Hu B, Li W, Hao J*, and Zhou Q*. (2018) Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions. J Tissue Eng Regen Med. 2018 Jan; 12(1):153-63.
  9. Gu Q#, Wang J#, Wang L#, Liu Z, Zhu, W Tan, Y Q, Han W, Wu J, Feng C, Fang J, Liu L, Wang L, Li W, Zhao X, Hu B, Hao J*, Zhou Q*. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem cell reports. 2017 Jul 11; 9(1): 366-80.
  10. Gu Q#, Zhu H#, Chen L, Shuai L, Fang J, Wu J, Liu L, Li W, Dai J, Hao J*, Zhou Q*. Three dimensional collagen scaffolds promote iPSC induction with higher pluripotency. Protein cell. 2016 Nov; 7(11): 844-8.
  11. Wang J#, Hao J#, Bai D, Gu Q, Han W, Wang L, Tan Y, Li X, Xue K, Han P, Liu Z, Jia Y, Wu J, Liu L, Wang L, Li W, Liu Z*, Zhou Q*. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. Stem Cell Res Ther. 2015 Nov 12; 6(1):223.
  12. Gu Q#, Hao J#, Lu Y, Wang L, Wallace GG*, Zhou Q*. Three-dimensional bio-printing. Sci China Life Sci. 2015 May; 58(5):411-9.
  13. Gu Q#, Hao J#, Hai T, Wang J, Jia Y, Kong Q, Wang J, Feng C, Xue B, Xie B, Liu S, Li J, He Y, Sun J, Liu L, Wang L, Liu Z*, Zhou Q*. Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. Protein Cell. 2014 May; 5(5):338-42.
  14. Wang J#, Gu Q#, Hao J#, Bai D, Liu L, Zhao X, Liu Z, Wang L, Zhou Q*. Generation of induced pluripotent stem cells with high efficiency from human umbilical cord blood mononuclear cells. Genomics Proteomics Bioinformatics. 2013 Oct; 11(5):304-11.
  15. Wang J#, Gu Q#, Hao J#, Jia Y, Xue B, Jin H, Ma J, Wei R, Hai T, Kong Q, Bou G, Xia P, Zhou Q, Wang L*, Liu Z*. Tbx3 and Nr5α2 play important roles in pig pluripotent stem cells. Stem Cell Rev and Rep. 2013; 9(5):700-8.
  16. Gu Q#, Hao J#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q*. Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. Protein Cell. 2012 Jan; 3(1):71-9.
  17. Hai T#, Hao J#, Li W, Jouneau A*, Zhou Q*. Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. Cell Reprogram. 2011 Feb; 13(1):47-56.
  18. Dai X#, Hao J#, Hai T, Fan Y, Yu Y, Jouneau A, Zhou Q*. Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor. J Biol Chem. 2010 Oct 1; 285(40):31002-10.
  19. 中国科学技术协会组编，《新科技知识干部读本》（上中下），科学普及出版社，2016年，北京。
  20. 周琪主编，郝捷、王柳 副主编，《干细胞实验指南》，中央广播电视大学出版社，2015年，北京。