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Name:
 Jie Hao
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-62558737  / 
E-mail:
 haojie@ioz.ac.cn
Address:
 National Stem Cell Resource Center, No. 25-1, North Fourth Ring West Road, Haidian District, Beijing, China
More:
 National Stem Cell Resource Center      
Resume:

Dr. Jie Hao, Ph.D., is a researcher and the director of the National Stem Cell Resource Center (NSCRC) at the Institute of Zoology, Chinese Academy of Sciences (CAS). She earned her Bachelor of Science from Northwest A&F University in 2004 and her Ph.D. in Science from the Chinese Academy of Sciences in 2010. Following the completion of her postdoctoral fellowship in 2012, she joined the Institute of Zoology as a full-time researcher.

Dr. Hao has published over 60 articles in journals such as Cell Research as corresponding and first author (including co-first authorships), and has contributed to 6 edited volumes. She has led or participated in more than 20 national and provincial research projects, secured over 20 invention patents, and spearheaded the formulation of more than 30 domestic and international standards, receiving upwards of 10 national and provincial awards.

Building on her research achievements, she has been involved in over 10 stem cell clinical studies registered with national authorities and contributed to the successful approvals of 5 phase I/II clinical trials from the National Medical Products Administration, with several projects successfully yielding technological innovations. In recognition of her contributions during the COVID-19 pandemic, she has received honors including the National “March 8th Red Banner Pacesetter”, while her team has been awarded accolades such as the National “May Day Model for Women” and the Chinese Academy of Sciences Advanced Collective Award.

Research Interests:

The long-term goal of Dr. Jie Hao’s research is to develop innovative cellular resources—including novel stem cells and other cell types for the biopharmaceutical industry—and to advance the development of stem cell-based therapeutics. Dr. Jie Hao is dedicated to establishing a standardized stem cell resource bank and exploring effective pathways for translating stem cell research into clinical applications while supporting technological innovation.

Awards and Honors:

Professional Activities:

Registered Expert, ISO/TC 276 WG4, International Organization for Standardization

Member, Chinese Society for Cell Biology (CSCB), Chinese Society for Stem Cell Research (CSSCR)

Vice Chair, Standards Working Committee, Chinese Society for Stem Cell Research (CSSCR)

Deputy Secretary-General, China Alliance of Stem Cell and Regenerative Medicine (CASCRM)

Committee Member, 5th Assessment Committee, China National Accreditation Service for Conformity Assessment (CNAS)

Committee Member, Biological Sample Bank Technical Committee; Technical Assessor for Biobanks and Testing Laboratories, CNAS

Member, Youth Innovation Promotion Association of Chinese Academy of Sciences

Research Grants:

Led or participated in many projects, including the CAS Strategic Leading Science and Technology Project, National Key R & D Plan, CAS Key Deployment Projects, etc.

Selected Publications:
  1. Song D#, Li Z#, Sun F#, Wu K#, Zhang K, Liu W, Liu K, An B, Wang Z, Zhao T, Chen H, Xiao L, Wang L, Xie L, Li W, Peng L, Hao J*, Wu J*, Dai H*. Optimized administration of human embryonic stem cell-derived immunity-and-matrix regulatory cells for mouse lung injury and fibrosis. Stem Cell Res Ther. 2024 Oct 8;15(1):344.
  2. Niu S#, Xia C#, Huang D#, Wang L#, Hu H, Yu S, Wu N, Dong Z, Zhou J, Wu J, Yu J, Zhang Y, Wang C, Fu B, Cao J, Liang L, Xu L, Chen L, Zhou Q, Ma A*, Zhao T*, Hao J*, Wang J*.Requirements for human natural killer cells. Cell Prolif. 2024 May;57(5):e13588.
  3. Peng Y#, Ma A#, Xiao Z#, Hao J#, Feng R, Wang C, Hu B, Zhai P, Li K, Wang L, Cao J, Xiang P, Zhang Y, Wei J, Wang X, Fu B, Chen Q, Wei Q, Gao H, Lv J, Liu X, Ma Y, Cheng T, Huang X, Su Y, Zhang H*, Zhou Q*, Zhao T*. Technical specifications for ethics review of human stem cell research. Cell Prolif. 2024 Mar;57(3):e13556.
  4. Huang L#, Zhang S#, Wu J#, Guo B#, Gao T, Shah SZA, Huang B, Li Y, Zhu B, Fan J, Wang L, Xiao Y, Liu W, Tian Y, Fang Z, Lv Y, Xie L, Yao S, Ke G, Huang X, Huang Y, Li Y, Jia Y, Li Z, Feng G, Huo Y, Li W, Zhou Q, Hao J*, Hu B*, Chen H*. Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial. Signal Transduct Target Ther. 2023 Nov 1;8(1):417.
  5. Ji T#, Niu S#, Fang M#, Xu L#, Wang X, Wu J, Xu F, Zhang M. Niu R, Wu J, Wang L, Li Z, Yang Y, Hao J*, Li W*, Hu Z*, Zhou Q*. Genome editing HLA alleles for a pilot immunocompatible hESC line in a Chinese hESC bank for cell therapies. Cell Proliferation 56. Cell Prolif. 2023 May;56(5):e13471.
  6. Guo B#, Duan Y#, Li Z#, Tian Y, Cheng X, Liang C, Liu W, An B, Wei W, Gao T, Liu S, Zhao X, Niu S, Wang C, Wang Y, Wang L, Feng G, Li W, Hao J*, Gu Q*, Zhou Q*, Wu J*. High-Strength Cell Sheets and Vigorous Hydrogels from Mesenchymal Stem Cells Derived from Human Embryonic Stem Cells. ACS Appl Mater Interfaces. 2023 Jun 14;15(23):27586-27599.
  7. Gao T#, Zhao X#, Hao J#, Tian Y, Ma H, Liu W, An B, Sun F, Liu S, Guo B, Niu S, Li Z, Wang C, Wang Y, Feng G, Wang L, Li W, Wu J*, Guo M*, Zhou Q*, Gu Q*. A scalable culture system incorporating microcarrier for specialised mesenchymal stem cells from human embryonic stem cells. Mater Today Bio. 2023 May 5:20:100662.
  8. Zhou H#, Cui Z#, Wang H#, Gao T, Wang L, Wu J, Xiong Z*, Hao J*, Zhao M*. The therapeutic effects of human embryonic stem cells-derived immunity-and-matrix regulatory cells on membranous nephropathy. Stem Cell Res Ther. 2022 Jun 7;13(1):240.
  9. Yang S#, Liu P#, Gao T#, Song D, Zhao X, Li Y, Wu J, Wang L, Wang Z*, Hao J*, Wang C*, and Dai H*. Every road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes. Stem Cell Res Ther. 2022 Apr 12;13(1):163.
  10. Wang L#, Cao J#, Peng Y#, Fu B#, Jin Z, Hu Y, Wu W, Xiang AP, Hu S, Yu J, Zhang Y, Wei J, Zhang Y, Li Q, Zhou J, Zhai P, Zhu H, Liang L, Ma A*, Stacey G*, Zhao T*, Hao J*. Human retinal pigment epithelial cells. Cell Prolif. 2022 Apr;55(4):e13153.
  11. Zhang B, Wu X, Zi G, He L, Wang S, Chen L, Fan Z, Nan X, Xi J, Yue W, Wang L, Wang L, Hao J*, Pei X*, Li Y*. Large-scale generation of megakaryocytes from human embryonic stem cells using transgene-free and stepwise defined suspension culture conditions. Cell Prolif. 2021 Apr;54(4):e13002.
  12. Cao J#, Hao J#, Wang L#, Tan Y, Tian Y, Li S, Ma A, Fu B, Dai J, Zhai P, Xiang P, Zhang Y, Cheng T, Peng Y*, Zhou Q*, Zhao T*. Developing standards to support the clinical translation of stem cells. Stem Cells Transl Med. 2021 Nov;10 Suppl 2(Suppl 2):S85-S95.
  13. Wu J#, Song D#, Li Z#, Guo B#, Xiao Y, Liu W, Liang L, Feng C, Gao T, Chen Y, Li Y, Wang Z, Wen J, Yang S, Liu P, Wang L, Wang Y, Peng L, Stacey GN, Hu Z, Feng G, Li W, Huo Y, Jin R, Shyh-Chang N, Zhou Q, Wang L*, Hu B, Dai H*, Hao J*. Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis. Cell Res. 2020 Sep;30(9):794-809.
  14. Xing D, Wu J, Wang B, Liu W, Liu W, Zhao Y, Wang L, Li JJ, Liu A, Zhou Q, Hao J*, Lin J*. Intra-articular delivery of umbilical cord-derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model. Int J Rheum Dis. 2020 Apr 21.
  15. Li Z#, Wu J#, Wang L#, Han W, Yu J, Liu X, Wang Y, Zhang Y, Feng G, Li W, Stacey GN, Gu Q, Hu B, Wang L, Zhou Q*, Hao J*. Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. Cell Death Dis. 2019 Oct 10;10(10):763.
  16. Wang L#, Wu W#, Gu Q#, Liu Z, Li Q, Li Z, Fang J, Liu W, Wu J, Zhang Y, Wang L, Xu H, Li W, Hu B, Zhou Q*, Yin Z*, Hao J*. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. Protein Cell. 2019 Jun;10(6):455-460.
  17. Ma J#, Wu J#, Han L, Jiang X, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic membrane, umbilical cord and chorionic plate under serum-free condition. Stem Cell Res Ther. 2019 Jan 11;10(1):19.
  18. Li X#, Ma R#, Gu Q#, Liang L, Wang L, Zhang Y, Wang X, Liu X, Li Z, Fang J, Wu J, Wang Y, Li W, Hu B, Wang L*, Zhou Q*, Hao J*. A fully defined static suspension culture system for large-scale human embryonic stem cell production. Cell Death Dis. 2018 Sep; 9(9): 892.
  19. Cao Y#, Sun H#, Zhu H#, Zhu X, Tang X, Yan G, Wang J, Bai D, Wang J, Wang L, Zhou Q, Wang H, Dai C, Ding L, Xu B, Zhou Y, Hao J*, Dai J*, Hu Y*. Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther. 2018 Jul 11; 9(1): 192.
  20. Tan Y#, Han P#, Gu Q#, Chen G, Wang L, Ma R, Wu J, Feng C, Zhang Y, Wang L, Hu B, Li W, Hao J*, and Zhou Q*. (2018) Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions. J Tissue Eng Regen Med. 2018 Jan; 12(1):153-63.
  21. Gu Q#, Wang J#, Wang L#, Liu Z, Zhu, W Tan, Y Q, Han W, Wu J, Feng C, Fang J, Liu L, Wang L, Li W, Zhao X, Hu B, Hao J*, Zhou Q*. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem cell reports. 2017 Jul 11; 9(1): 366-80.
  22. Gu Q#, Zhu H#, Chen L, Shuai L, Fang J, Wu J, Liu L, Li W, Dai J, Hao J*, Zhou Q*. Three dimensional collagen scaffolds promote iPSC induction with higher pluripotency. Protein cell. 2016 Nov; 7(11): 844-8.
  23. Wang J#, Hao J#, Bai D, Gu Q, Han W, Wang L, Tan Y, Li X, Xue K, Han P, Liu Z, Jia Y, Wu J, Liu L, Wang L, Li W, Liu Z*, Zhou Q*. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. Stem Cell Res Ther. 2015 Nov 12; 6(1):223.
  24. Gu Q#, Hao J#, Lu Y, Wang L, Wallace GG*, Zhou Q*. Three-dimensional bio-printing. Sci China Life Sci. 2015 May; 58(5):411-9.
  25. Gu Q#, Hao J#, Hai T, Wang J, Jia Y, Kong Q, Wang J, Feng C, Xue B, Xie B, Liu S, Li J, He Y, Sun J, Liu L, Wang L, Liu Z*, Zhou Q*. Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. Protein Cell. 2014 May; 5(5):338-42.
  26. Wang J#, Gu Q#, Hao J#, Bai D, Liu L, Zhao X, Liu Z, Wang L, Zhou Q*. Generation of induced pluripotent stem cells with high efficiency from human umbilical cord blood mononuclear cells. Genomics Proteomics Bioinformatics. 2013 Oct; 11(5):304-11.
  27. Wang J#, Gu Q#, Hao J#, Jia Y, Xue B, Jin H, Ma J, Wei R, Hai T, Kong Q, Bou G, Xia P, Zhou Q, Wang L*, Liu Z*. Tbx3 and Nr5α2 play important roles in pig pluripotent stem cells. Stem Cell Rev and Rep. 2013; 9(5):700-8.
  28. Gu Q#, Hao J#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q*. Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. Protein Cell. 2012 Jan; 3(1):71-9.
  29. Hai T#, Hao J#, Li W, Jouneau A*, Zhou Q*. Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. Cell Reprogram. 2011 Feb; 13(1):47-56.
  30. Dai X#, Hao J#, Hai T, Fan Y, Yu Y, Jouneau A, Zhou Q*. Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor. J Biol Chem. 2010 Oct 1; 285(40):31002-10.