Location: Home > Scientists
  Scientists
Name:
 SHAO Xuan
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807083  / 
E-mail:
 shaoxuan@ioz.ac.cn
Address:
 Beijing Institute of Stem Cell and Regenerative Medicine, Datun Road Jia 3, Chaoyang District, Beijing, 100101, P.R. China
More:
 Reproductive Pathology Group      
Resume:

Xuan Shao, Ph.D., associate professor, member of the reproductive pathology group, institute of Zoology, CAS. He presides over the National Natural Science Foundation General Project and Youth Science Fund Project and serves as a principal contributor to the National Key R&D Program projects, and the National Natural Science Foundation Major Projects and the Key Projects. Dr. Shao completed his undergraduate studies at Hebei University in 2006 and later earned his Ph.D. from the Institute of Zoology, Chinese Academy of Sciences, in 2014 under the guidance of Professor Yan-Ling Wang. He was promoted to Associate Professor in 2021.

Dr. Shao’s primary research interests lie in the regulation of pregnancy adaptation and trophoblast cell metabolism. He utilizes these areas as a foundation to delve into the regulatory mechanisms governing placental endocrine and metabolic functions, as well as the placenta-derived origins of pregnancy-related diseases such as pre-eclampsia. His specific research endeavors encompass: the establishment and regulatory mechanisms of the placental nutrient transmission functional unit; and the etiology of significant pregnancy disorders like pre-eclampsia and fetal growth restriction. Dr. Shao has authored 26 papers in peer-reviewed journals, including Natl Sci Rev, PNAS, J Pineal Res, J Biomed Sci, Genomics Proteomics Bioinformatics, Cell Chem Biol, Hypertension, among others. He has obtained 1 national invention patent and 1 international PCT patent. Currently, he serves as a review expert for the Beijing Natural Science Foundation projects and as a reviewer for Adv Sci, Commun Biol, Sci Rep, Reprod Biol Endocrinol, Front Cell Dev Biol, Front Endocrinol, Biol Reprod, Placenta, BMC Pregnancy Childbirth, and more. He is currently mentoring one master’s student.

Research Interests:

Awards and Honors:

Professional Activities:

Research Grants:
  • National Key Research and Development Program (2022YFA1103601): The Spatial-Temporal Map Analysis of the Formation of Immune Tolerance at the Maternal-Fetal Interface (P.I. 2022.12-2027.11) Amount: RMB 2,230,000
  • National Natural Science Foundation of China Major Research Project (82192872): The development of extra-embryonic tissue in primates and repeated pregnancy failures (P.I. 2022.01-2026.12) Amount: RMB 1,500,000
  • National Natural Science Foundation of China General Research Project (32171115): The study of the mechanism of regulation of glucose metabolism on the syncytialization of placental trophoblast cells (P.I. 2022.01-2025.12) Amount: 580,000
  • National Natural Science Foundation of China Youth Research Project (31800986): The mechanism by which placental trophoblast cells enhance macropinocytosis through syncytialization to cope with adverse nutritional microenvironments (P.I. 2019.01-2021.12). Amount: RMB 250,000
  • National Key Research and Development Program (2018YFC1004100): The Molecular Mechanism of Placental Formation (P.I. 2018.12-2021.12) Amount: RMB 1,080,000
  • National Natural Science Foundation of China Key Research Project (81730040): The mechanism of the disorder of steroid hormone synthesis and metabolism during pregnancy leading to the development of preeclampsia (P.I. 2018.01-2021.12) Amount: RMB 2,940,000

Selected Publications:
  1. Jia W#, Ma L#, Yu X#, Wang F, Yang Q, Wang X, Fan M, Gu Y, Meng R, Wang J, Li YX, Li R*, Shao X*, Wang YL*. Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss. Natl Sci Rev. 2024 Apr 11;11(6):nwae142.
  2. Fan M#, Wu H#, Sferruzzi-Perri AN*, Wang YL*, Shao X*. Endocytosis at the Maternal-Fetal Interface: Balancing Nutrient Transport and Pathogen Defense. Front Immunol. 2024 Jun 18:15:1415794.
  3. Shao X#, Yang Y#, Liu Y#, Wang Y#, Zhao Y, Yu X, Liu J, Li YX, Wang YL*. Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta. J Pineal Res. 2023 :e12913.
  4. Shao X#, Yu W#, Yang Y#, Wang F, Yu X, Wu H, Ma Y, Cao B*, Wang YL*. The mystery of the life tree: the placenta. Biol Reprod. 2022;107(1):301-316.
  5. Chen J#, Du L#, Wang F#, Shao X#, Wang X, Yu W, Bi S, Chen D, Pan X, Zeng S, Huang L, Liang Y, Li Y, Chen R, Xue F, Li X, Wang S, Zhuang M, Liu M, Lin L, Yan H, He F, Yu L, Jiang Q, Xiong Z, Zhang L, Cao B*, Wang YL*, Chen D*. Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at mid-gestation highlights the defective impacts on fetal health. Cell Prolif. 2022;55(4):e13204.
  6. Yu X#, Wu Hong#, Yang Y, Wang F, Wang YL*, Shao X*. Placental development and Pregnancy-Associated Diseases. Maternal-Fetal Medicine. 2022;4(1):36-51.
  7. Li G#, Wang Y#, Cao G#, Ma Y, Li YX, Zhao Y*, Shao X*, Wang YL*. Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia. J Biomed Sci. 2022;29(1):8.
  8. Shao X#, Cao G#, Chen D#, Liu J, Yu B, Liu M, Li YX, Cao B*, Sadovsky Y*, Wang YL*. Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply. Proc Natl Acad Sci U S A. 2021;118(3):e2017092118.
  9. Liu J#, Shao X#, Qin W#, Yanling Zhang#, Dang F, Yang Q, Yu X, Li YX, Chen X, Wang C*, Wang YL*. Quantitative chemoproteomics reveals O-GlcNAcylation of Cystathionine γ-lyase (CSE) represses trophoblast syncytialization. Cell Chem Biol. 2021;S2451-9456(21)00050-7. (Cover story)
  10. Wang F#, Jia W#, Fan M#, Shao X#. Li Z, Liu Y, Ma Y, Shao X, Li YX, Li R*, Tu Q*, Wang YL*. Single-cell immune landscape of human recurrent miscarriage. Genomics Proteomics Bioinformatics. 2021;19:S1672-0229(21)00003-6. (Editorial highlight)
  11. Bian X, Liu J, Yang Q, Liu Y, Jia W, Zhang X, Li YX, Shao X*, Wang YL*. miR-210 regulates placental adaptation to maternal hypoxic stress during pregnancy. Biol Reprod. 2021;104(2):418-429.
  12. Ma Y#, Yang Q#, Fan M#, Zhang L, Gu Y, Jia W, Li Z, Wang F, Li YX, Wang J, Li R*, Shao X*, Wang YL*. Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation. Cell Prolif. 2020;53(5):e12802.
  13. Li Z#, Bian X#, Ma Y, Yang Q, Jia W, Liu J, Wang F, Liu M, Li YX, Shao X*, Wang YL*. Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids. Endocrinology, 2020;161(11):bqaa174.
  14. Shao X#, Wang Y#, Liu Y#, Guo X, Li D, Huo R, Jia W, Cao G, Li YX, Liu M, Sha J, Zhao Y, Wang YL*. Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia. J Hypertens. 2019;37(1):197-205.
  15. Shao X, Tan C, Chen D, Wang YL*. Placental defects are involved in most gene mutations that cause embryonic and fetal death. Biol Reprod. 2018;99(3):476-478.
  16. Shao X#, Liu Y#, Liu M, Wang Y, Yan L, Wang H, Ma L, Li YX, Zhao Y*, Wang YL*. Testosterone Represses Estrogen Signaling by Upregulating miR-22: A Mechanism for Imbalanced Steroid Hormone Production in Preeclampsia. Hypertension. 2017;69(4):721-730. (Editorial highlight)
  17. Luo R#, Shao X#, Xu P, Liu Y, Wang Y, Zhao Y, Liu M, Ji L, Li YX, Chang C, Qiao J, Peng C*, Wang YL*. MicroRNA-210 contributes to preeclampsia by down-regulating KCMF1. Hypertension, 2014;64:839-847.