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Name:
 Li Zhi-kun
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807297  / 
E-mail:
 lizhikun@ioz.ac.cn
Address:
 The State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, CAS, Yard A 3, Datun Road, Chaoyang District, Beijing 100101, China
More:
 Group of Stem Cells and Cell Cycle Regulation      
Resume:

Zhikun Li, Ph.D. Associate Professor, Member of the Stem Cell and Cell Cycle Regulation Research Group.

Education and Professional Experience

  • September 2004 – June 2008
    Bachelor of Science, College of Life Science and Technology, Huazhong Agricultural University.
  • September 2008 – June 2015
    Doctorate in Developmental Biology, Institute of Zoology, Chinese Academy of Sciences (CAS). PhD advisor: Academician Qi Zhou.
  • June 2015 – August 2016
    Research Assistant, Group of Reproductive Engineering, Institute of Zoology, CAS.
  • August 2016 – December 2020
    Postdoctoral Fellow, Group of Stem Cell and Cell Cycle Regulation, Institute of Zoology, CAS. Advisor: Prof. Wei Li.
  • December 2020 – Present
    Associate Professor, Group of Stem Cell and Cell Cycle Regulation, Institute of Zoology, CAS.

Research Interests:

Dr. Zhikun Li is dedicated to studying the molecular mechanisms of genomic imprinting dysregulation and strategies for its correction. His earlier work utilized various genetic modifications to validate the enhanced differentiation potential and developmental stability of pluripotent stem cells with corrected imprinting. Future research will build on these findings to further explore the biological mechanisms underlying diverse cellular and animal models.

Awards and Honors:

Professional Activities:

Research Grants:
  • Youth Innovation Promotion Association of the Chinese Academy of Sciences (E229561101), 2022–2026.
  • Postdoctoral Innovative Talent Support Program (BX201600161), 2016–2018.

Selected Publications:

(# indicates co-first authorship)

  1. Wang LB#, Li ZK#, Wang LY#, Xu K#, Ji TT#, Mao YH, Ma SN, Liu T, Tu CF, Zhao Q, Fan XN, Liu C, Wang LY, Shu YJ, Yang N, Zhou Q*, Li W.* (2022). A sustainable mouse karyotype created by programmed chromosome fusion. Science, 377: 967-975.
  2. Wang LY#, Li ZK#, Wang LB#, Liu C#, Sun XH#, Feng GH#, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL*, Li W*, Zhou Q*. (2020). Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Postimplantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell, 27: 315-325.
  3. Li ZK#, Wang LY#, Wang LB#, Feng GH#, Yuan XW#, Liu C#, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. (2018). Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell, 23: 665-676.
  4. Li ZK#, Wan HF#, Feng GH#, Wang LY#, He ZQ, Wang YK, Wang XJ, Li W*, Zhou Q*, Hu BY*. (2016). Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res., 26(1): 135-138.
  5. Li ZK#, Wang LB#, Wang YK#, Liu L, Wang L, Li W*, Zhou Q*. (2015). Generation of an lncRNA Gtl2-GFP reporter for rapid assessment of pluripotency in mouse induced pluripotent stem cells. J Genet Genomics, 42(3): 125-128.
  6. Guo L#, Li ZK#, Li YH#, Qu B#, Jiao GY#, Liang C, Lu ZB, Wang XG, Huang C, Du HW, Liang JM, Zhou Q*, Li W*. (2022). Treatment of glutaric aciduria type I (GA-I) via intracerebroventricular delivery of GCDH. Fundam. Res., 2(6): 836-842.
  7. Qu B#, Wu SJ#, Jiao GY#, Zou X#, Li ZK#, Guo L#, Sun XH, Huang C, Sun ZX, Zhang Y, Li H, Zhou Q*, Sui RF*, Li W*. (2020). Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy. Gene Ther., 27: 370-382.