Research Interests:

Dr. Wang engaged in the study of stem cell fate regulation and nerve regeneration, especially in brain repair of neurological diseases such as Parkinson's disease and stroke. His focus is: 1. Cell fate specification and how to efficiently drive controlled differentiation of human stem cells into neural subtypes 2. Development of neural organoids for disease modeling and drug screening 3. Development of clinical-grade neuronal cell drugs for use in brain repair.

Awards and Honors:

Professional Activities:

Research Grants:

General Program of National Natural Science Foundation of China Youth Program of National Natural Science Foundation of China National Key Research and Development Program Strategic Priority Research Program of the Chinese Academy of Sciences Key Deployment Projects of the Chinese Academy of Sciences

Selected Publications:

Zhao YL#, Wu J, Li D, Liu J, Chen WQ, Hou ZR, Liu KL, Jiang LL, Chen XW, Wang L, Hu BY, Zong FR*, Wang YK*, Wang YL*. Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion. Cell Proliferation. 2022, Apr 19;e13223. Sun Y#, Feng L#, Liang LM#, Stacey GN, Wang CQ, Wang YK*, Hu BY*. Neuronal cell-based medicines from pluripotent stem cells: development, production, and pre-clinical assessment. STEM CELLS Translational Medicine. 2021; Nov;10 Suppl 2(Suppl 2):S31-S40. Liu J#, Hou ZR#, Wu J#, Liu KL, Li D, Gao TT, Liu WJ, An B, Sun Y, Mo F, Wang L, Wang YK*, Hao J*, Hu BY*. Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Proliferation. 2021; Aug;54(8):e13085. Wang YK#, Zhu WW#, Wu MH#, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY, Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease, Stem Cell Reports, 2018, 11(1): 171-182 Wang JQ#, Wang LY#, Feng GH#, Wang YK#, Li YF, Li X, Liu C, Jiao GY, Huang C, Shi JC, Zhou T, Chen Q, Liu ZH, Li W, Zhou Q, Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, Cell, 2018, 175(7): 1887-1901 He ZQ#, Xia BL#, Wang YK#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q, Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening, Cell Reports, 2017, 20(9): 2227-2237 Lu XY#, Wang YK#, Yan L, Wang LB, Li W, Wang HM, Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs, Journal of Genetics and Genomics, 2016, 43(10): 609-612 Li X#, Cu XLi#, Wang JQ#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells, Cell, 2016, 164(1-2): 279-292 Li ZK#, Wang LB#, Wang YK#, Liu L, Wang L, Li W, Zhou Q, Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells, Journal of Genetics and Genomics, 2015, 42(3): 125-128 Shuai L#, Wang YK#, Dong MZ#, Wang XP#, Sang LS, Wang M, Wan HF, Luo GZ, Gu TT, Yuan Y, Feng CJ, Teng F, Li W, Liu XY, Li TD, Wang L, Wang XJ, Zhao XY, Zhou Q, Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro, J Mol Cell Biol, 2015, 7(4): 326-337 Wang LB#, Cao JN#, Wang YK#, Lan TS#, Liu L, Wang WX, Jin N, Gong JQ, Zhang C, Teng F, Yan GL, Li C, Li JL, Wan HF, Hu BY, Li W, Zhao XY, Qi ZQ, Zhao TB, Zhou Q, Immunogenicity and functional evaluation of iPSC-derived organs for transplantation, Cell Discovery, 2015, 7;1:15015 Wang YK#, Zhao GY#, Li Y, Chen XL, Xie BB, Su HN, Lv YH, He HL, Liu H, Hu J, Zhou BC, Zhang YZ, Mechanistic insight into the function of the C-terminal PKD domain of the collagenolytic serine protease deseasin MCP-01 from deep sea Pseudoalteromonas sp. SM9913: binding of the PKD domain to collagen results in collagen swelling but does not unwind the collagen triple helix, J Biol Chem, 2010, 285(19): 14285-14291 Wang YK#, He HL, Wang GF, Wu H, Zhou BC, Chen XL, Zhang YZ, Oyster (Crassostrea gigas) hydrolysates produced on a plant scale have antitumor activity and immunostimulating effects in BALB/c mice, Marine Drugs, 2010, 8(2): 255-268   Wang YK#, He HL, Chen XL, Sun CY, Zhang YZ, Zhou BC, Production of novel angiotensin I-converting enzyme inhibitory peptides by fermentation of marine shrimp Acetes chinensis with Lactobacillus fermentum SM 605, Appl Microbiol Biotechnol, 2008, 79(5): 785-791