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Name:
 ZHANG Ying
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807297  /  +86-10-64807306
E-mail:
 yingzhang@ioz.ac.cn
Address:
 The State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Building of Institute for Stem Cell and Regeneration, CAS, Yard A 3, Datun Road, Chaoyang District, Beijing 100101, P.R.China
More:
 Group of Reproductive Engineering      
Resume:
Dr. Zhang received her Ph.D. and postdoctoral training in Peking University. She is now an associate professor at the State Key Laboratory of Stem cell and Reproductive Biology. She is working in the field of epigenetic modification and stem cell pluripotency.

Research Interests:
Dr. Zhang’s main research interests are non-coding RNA, RNA methylation and stem cell pluripotency.

Awards and Honors:

Professional Activities:

Research Grants:

National Natural Science Foundation of China (81972633), 2020-2023

National Key Research and Development Program (2019YFA0110801), 2019-2023

National Key Research and Development Program (2018YFC1004503), 2018-2021

National Basic Research Program of China (2014CB964903), 2014-2018

National Natural Science Foundation of China (30900856), 2010-2012

Selected Publications:

（#co-first author, *corresponding author）

  1. Jiang H#, Chen Y#, He Z#, Li J#, Gao Q, Li W, Wei W*, Zhang Y*. (2023) Targeting non-muscle myosin II inhibits proliferative vitreoretinopathy through regulating epithelial-mesenchymal transition. Biochem Biophys Res Commun. Oct 27;686:149149.
  2. Ying S#, Li P#, Wang J#, Chen K#, Zou Y, Dai M, Xu K, Feng G, Zhang C, Jiang H, Li W, Zhang Y*, Zhou Q*. (2023) tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis. Signal Transduct Target Ther. Apr 3;8(1):144. (Cover Story)
  3. He Z#, Yuan X#, Lu Z#, Li Y#, Li Y, Liu X, Wang L, Zhang Y*, Zhou Q*, Li W*. (2022) Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts. Fundamental Research. 2(1):37-47. (Cover Story)
  4. Jiao G#, Wang C#, Chen Y#, Dai M, Zhang Y*, Li W*. (2022) Enhancing targeted transgene knock-in by donor recruitment. Cell Prolif. Jan;55(1):e13163.
  5. Mao Y#, Wang L#, Zhong B#, Yang N#, Li Z, Cui T, Feng G, Li W, Zhang Y*, Zhou Q*. (2021) Continuous expression of reprogramming factors induces and maintains mouse pluripotency without specific growth factors and signaling inhibitors. Cell Prolif. Aug;54(8):e13090.
  6. Li Y#, Guo L#, Ying S#, Feng GH, Zhang Y*. (2020) Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells. Cell Prolif. Oct;53(10):e12903.
  7. Mao J#, Xu K#, Han J#, Feng G, Zhang Y*, Li W*. (2020) Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon. Protein Cell. Jun;11(6):452-457.
  8. Li J#, Wang C#, Feng G#, Zhang L#, Chen G, Sun H, Wang J, Zhang Y*, Zhou Q*, Li W*. (2020) Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. Cell Prolif. Jan;53(1):e12724.
  9. Yuan X#, He Z#, Mao J#, Hu Y#, Liu X, Guo J, Liu Z, Zhang Y*, Li W*, Zhou Q*. (2019) Reprogramming of fibroblasts to uterine glandular epithelium by a chemical cocktail induction. Cell Discov. May 14;5:26. 
  10. Li Y#, Wang L#, Zhang L#, He Z#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y*, Zhou Q*, Li W*. (2019) Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. J Cell Biol. May 6;218(5):1553-1563.
  11. Chen G#, Zhang D#, Zhang L#, Feng G, Zhang B, Wu Y, Li W, Zhang Y*, Hu B*. (2018) RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. Biochem Biophys Res Commun. Jun 18;501(1):259-265.
  12. Zhang W, Feng G, Wang L, Teng F, Wang L, Li W, Zhang Y*, Zhou Q*. (2018) MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation. J Mol Cell Biol. Dec1;10(6):515-526. (Highlight in Natl Sci Rev) 
  13. Zhang Y#, Guo L#, Li Y#, Feng GH, Teng F, Li W, Zhou Q*. (2018) MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer. Mol Cancer. Jan 5;17(1):1. 
  14. Zhang Y#, Cui P#, Li Y#, Feng G, Tong M, Guo L, Li T, Liu L, Li W, Zhou Q*. (2018) Mitochondrially produced ATP affects stem cell pluripotency via Actl6a-mediated histone acetylation. FASEB J. Apr;32(4):1891-1902. 
  15. Zhang Y, Zhou Q*. (2017) A single-cell snapshot of cell-fate decisions. J Biol Chem. Jun 9;292(23):9855-9856.
  16. Zhang Y*, Wang S, Li L*. (2016) EF hand protein IBA2 promotes cell proliferation in breast cancers via transcriptional control of cyclin D1. Cancer Res. Aug 1;76(15):4535-45. 
  17. Zhang Y, Feng GH, Xu K, Wang L, Cui P, Li Y, Wang C, Teng F, Hao J, Wan HF, Tan Y, Wang XJ*, Zhou Q*. (2016) A non-invasive method to determine the pluripotent status of stem cells by culture medium microRNA expression detection. Sci Rep. Mar 1;6:22380.
  18. Chen T#, Hao YJ#, Zhang Y#, Li MM#, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ*, Yang YG*, Zhou Q*. (2015) m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell. Mar 5;16(3):289-301. (Cover Story)
  19. Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao X, Wang L, Wang XJ*, Zhou Q*. (2013) MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells. J Biol Chem. Aug 16;288(33):23659-65.
  20. Liu X#, Zhang Y#, Tong M, Liu XY, Luo GZ, Xie DF, Ren SF, Bai DH, Wang L, Zhou Q, Wang XJ*. (2013) Identification of a small compound as a novel inhibitor of the p53 transcription factor. Acta Pharmacol Sin. Jun;34(6):805-10.
  21. Zhang Y, Zhang H, Liang J, Yu W, Shang Y*. (2007) SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. EMBO J. Jun 6;26(11):2645-57.