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Name:
 Han, Yuling
Subject:
 Regenerative Medicine
Tel/Fax:
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E-mail:
 hylwayne@ioz.ac.cn
Address:
 The State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences,1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
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Resume:

Professor and Investigator, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, China 2024-

Background:

B.S., Nankai University, China 2009-2013

Ph.D., Institute of Biophysics, Chinese Academy of Science, China 2013 - 2019

Postdoctoral fellow, Weill Medical College of Cornell University, 2019-2023

Research Interests:

Virus infections pose a serious threat to human health. Utilizing human embryonic stem cells and induced pluripotent stem cells to differentiate into various tissue cells or organoids for studying viral infections can overcome the limitations of traditional cell lines in modeling complex human cell and organ systems. Our research group employs differentiated organoids from stem cells to study infectious diseases, combining multi-omics sequencing technologies and high-throughput drug screening platforms to delve into the mechanisms of virus-host interactions and explore potential therapeutic strategies.

Awards and Honors:

2019             President's Excellent Award of UCAS

2020-2023        NYSTEM Postdoctoral Fellowship

2022-Current      Frontiers in Genetics, Associate Editor

2022-Current      Frontiers in Cell and Developmental Biology, Associate Editor

2022-Current      Frontiers in Virology, Review Editor

Professional Activities:

Research Grants:

Selected Publications:
  1. Han Y#, Duan X#, Yang L#, Nilsson-Payant BE#, Wang P#, Duan F#, Tang X#, Yaron TM#, Zhang T, Uhl S, Bram Y, Richardson C, Zhu J, Zhao Z, Redmond D, Houghton S, Nguyen DT, Xu D, Wang X, Jessurun J, Borczuk A, Huang Y, Johnson JL, Liu Y, Xiang J, Wang H#, Cantley LC*, tenOever BR*, Ho DD*, Pan FC*, Evans T*, Chen HJ*, Schwartz RE* and Chen S*. Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2021; 589: 270-275
  2. Wang X#, Xuan Y#, Han Y#, Ding X, Ye K, Yang F, Gao P, Goff SP and Gao G*. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. Cell. 2019; 176:625-635 e14.
  3. Han Y#, Tan L#, Zhou T#, Yang L#, Carrau L#, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D, Team NGSCA, Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A, Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T and Chen S*. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022; 29:1475-1490 e6.
  4. Yang L#, Han Y#, Nilsson-Payant BE#, Gupta V#, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffre F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC*, Ho DD*, tenOever BR*, Evans T*, Schwartz RE* and Chen S*. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020; 27:125-136 e7. Best of Cell Stem Cell 2020.
  5. Han Y#, Zhu J#, Yang L#, Nilsson-Payant BE#, Hurtado R, Lacko L, Sun X, Gade AR, Higgins CA, Sisso WJ, Dong X, Wang M, Zhengming Chen, Ho DD, Pitt GS, Schwartz RE*, tenOever BR*, Evans T* and Chen S*. SARS-CoV-2 infection Induces Ferroptosis of Sinoatrial Node-like Pacemaker Cells. Circ Res. 2022 130:963-977. Circulation Research Best Manuscript 2022.
  6. Han Y#, Yang L#, Lacko L and Chen S*. Human Organoid Models to Study SARS-CoV-2 Infection. Perspective, Nature Methods. 2022 4:418-428.
  7. Yang L#, Han Y#, Jaffre F#, Nilsson-Payant BE#, Bram Y#, Wang P, Zhu J, Zhang T, Redmond D, Houghton S, Uhl S, Borczuk A, Huang Y, Richardson C, Chandar V, Acklin JA, Lim JK, Chen Z, Xiang J, Ho DD, tenOever BR*, Schwartz RE*, Evans T* and Chen S*. An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circ Res. 2021 129:33-46. Cover story
  8. Yang L#, Kim TW#, Han Y#, Nair MS#, Harschnitz O#, Zhu J#, Wang P#, Koo SY, Lacko LA, Chandar V, Bram Y, Zhang T, Zhang W, He F, Pan C, Wu J, Huang Y, Evans T, van der Valk P, Titulaer MJ, Spoor JKH, Furler O'Brien RL, Bugiani M, W DJVdB, Schwartz RE*, Ho DD*, Studer L* and Chen S*. SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell Stem Cell. 2024.
  9. Yang L#, Nilsson-Payant BE#, Han Y#, Jaffré F#, Zhu J#, Wang P, Zhang T, Redmond D, Houghton S and M？ller R, Hoagland D, Carrau L, Horiuchi S, Goff M, Lim JK, Bram Y, Richardson C, Chandar V, Borczuk A, Huang Y, Xiang J, Ho DD*, Schwartz RE*, tenOever BR, Evans T* and Chen S*. Cardiomyocytes Recruit Monocytes upon SARS-CoV-2 Infection by Secreting CCL2. Stem Cell Reports. 2021 Jul 20.
  10. Yang L#, Han Y#, Zhou T#, Lacko LA, Saeed M, Tan C, Danziger R, Zhu J, Zhao Z, Cahir C, Giani AM, Li Y, Dong X, Moroziewicz D, Team NGSCA, Paull D, Chen Z, Zhong A, Noggle SA, Rice CM, Qi Q, Evans T and Chen S*. Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection. iScience. 2023;26:107001.