Research Interests:

Engaged primarily in research on ecological aging and aging plasticity. Aging is an inevitable life history process in animals, but the rate of aging is highly plastic in response to the environment. Locusts exhibit density-dependent phenotypic plasticity, with significant differences in lifespan and aging rate between gregarious and solitary phases. By leveraging the unique aging plasticity characteristics of locusts, we aim to unravel the molecular mechanisms underlying the aging plasticity in response to environmental changes, as well as the ecological adaptiveness of aging regulation in animals.

Awards and Honors:

Professional Activities:

Research Grants:

Initiative Scientific Research Program, Institute of Zoology, Chinese Academy of Sciences, 2024-2026, 2023IOZ0308 National Natural Science Foundation of China, 2022-2024, 32100388 China Postdoctoral Science Foundation, 2022-2023, 2021M703204

Selected Publications:

Guo Siyuan#, Hou Li#, Dong Liushu, Nie Xin, Kang Le* and Wang Xianhui*. PLIN2-induced ectopic lipid accumulation promotes muscle aging in gregarious locusts. Nature Ecology & Evolution (2023). (Cover Story) 10.1038/s41559-023-02059-z Hou Li#, Guo Siyuan#, Ding Ding, Du Baozhen and Wang Xianhui*. Neuroendocrinal and molecular basis of flight performance in locusts. Cellular and Molecular Life Sciences (2022). 10.1007/s00018-022-04344-9 Guo Siyuan#, Yang Pengcheng#, Liang Bo, Zhou Feng, Hou Li, Kang Le* and Wang Xianhui*. Aging features of the migratory locust at physiological and transcriptional levels. BMC Genomics (2021). 10.1186/s12864-021-07585-3 Guo Siyuan, Wang Xianhui and Kang Le*. Special significance of non-Drosophila insects in aging. Frontiers in Cell and Developmental Biology (2020). 10.3389/fcell.2020.576571 Guo Siyuan#, Jiang Feng#, Yang Pengcheng, Liu Qing, Wang Xianhui* and Kang Le*. Characteristics and expression patterns of histone-modifying enzyme systems in the migratory locust. Insect Biochemistry and Molecular Biology (2016). 10.1016/j.ibmb.2016.06.010 Hou Li, Guo Siyuan, Wang Yuanyuan, Shaoye Liu and Wang Xianhui*. Neuropeptide ACP is required for fat body lipid metabolism homeostasis in locusts. Insect Science (2024) 10.1111/1744-7917.13321 Hou Li, Guo Siyuan, Wang Yuanyuan, Nie Xin, Ding Ding, Li Beibei, Kang Le* and Wang Xianhui*. Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts. eLife (2021). 10.7554/eLife.65279 Zhu Dan#, Ge Jin#, Guo Siyuan, Hou Li, Shi Rangjun, Zhou Xian, Nie Xin and Wang Xianhui*. Independent variations in genome-wide expression, alternative splicing, and DNA methylation in brain tissues among castes of the buff-tailed bumblebee, Bombus terrestris. Journal of Genetics and Genomics (2021). 10.1016/j.jgg.2021.04.008 Chen Dafeng#, Hou Li#, Wei jianing, Guo Siyuan, Cui Weichan, Yang Pengcheng, Kang Le* and Wang Xianhui*. Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts. eLife (2022). 10.7554/eLife.74581 Ding Ding, Zhang Jie, Du Baozhen, Wang Xuanzhao, Hou Li, Guo Siyuan, Chen Bing* and Kang Le*. Non-canonical function of an Hif-1α splice variant contributes to the sustained flight of locusts. eLife (2022). 10.7554/eLife.74554 Chen Bing*, Jiang Chunyan, Guo Siyuan, Guo Kun and Hao Shuguang. Phenological asynchrony is associated with diapause program and heat shock protein expression in three grasshopper species in the inner Mongolian steppe. Frontiers in Ecology and Evolution (2021). 10.3389/fevo.2021.743872