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Name:
 LI Jingyi
Subject:
 Functional genomics of aging
Tel/Fax:
 +86-10-64807583  / 
E-mail:
 lijingyi@ioz.ac.cn
Address:
 State Key Laboratory of Membrane Biology, Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, 3A Datun Road, Chaoyang District, Beijing 100101, China
More:
 Group of Aging and Regeneration      
Resume:

Biography

2008 - 2012 B.S., Hebei Agricultural University

2012 - 2017 Ph.D., Peking University

2017 - 2019 Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

2019 – Now Associate Professor, Institute of Zoology, Chinese Academy of Sciences

Research Interests:

Utilizing an integrative multi-omics strategy, we aim to elucidate the intricate mechanisms of aging and the etiology of age-related diseases at multiple biological levels, thereby identifying novel therapeutic targets for the enhancement of geriatric interventions.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:

(#: co-first author)

  1. Sun S#, Li J#, Wang S#, Li J#, Ren J#, Bao Z#, Sun L#, Ma X#, Zheng F, Ma S, Sun L, Wang M, Yu Y, Ma M, Wang Q, Chen Z, Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ, Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J, Zhang W, Liu GH. CHIT1-positive microglia drive motor neuron aging in the primate spinal cord. Nature. 624(7992):611-620.
  2. Wang S#, Zheng Y#, Li J#, Yu Y#, Zhang W#, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC, Jing Qu, Tang F, Liu GH. Single-cell transcriptomic atlas of primate ovarian aging. Cell. 2020. 180(3): 585-600. (Cover story)
  3. Zhang W#, Li J#, Suzuki K#, Qu J#, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015. 348(6239):1160-1163.
  4. Li J#, Zheng Y#, Yan P#, Song M#, Wang S#, Sun L, Liu Z, Ma S, Chan P, Zhou Q, Belmonte JC, Zhang W, Liu GH, Tang F, Qu J. A single-cell transcriptomic atlas of primate pancreatic islet aging. National Science Review. 2021. 8(2):nwaa127.
  5. Li J#, Zhou X#, Liu X#, Ren J#, Wang J, Wang W, Zheng Y, Shi X, Sun T, Li Z, Kang A, Tang F, Wen L, Fu W. Detection of colorectal cancer in circulating cell-free DNA by methylated CpG tandem amplification and sequencing. Clinical Chemistry. 2019. 65(7):916-926.
  6. Yang J#, Li J#, Suzuki K#, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Belmonte JC, Qu J, Tang F, Liu GH. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Research. 2017. 27(9):1178-1181.
  7. Wen L#, Li J#, Guo H#, Liu X#, Zheng S, Zhang D, Zhu W, Qu J, Guo L, Du D, Jin X, Zhang Y, Gao Y, Shen J, Ge H, Tang F, Huang Y, Peng J. Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients. Cell Research. 2015. 25(11):1250-1264.

Reviews：

  1. Biomarkers of aging. Science China Life Science. 2023. 66(5):893-1066. (Cover story)
  2. The landscape of aging. Science China Life Science. 2022. 65(12): 2354–2454.