Research Interests:

We have been deeply engaged in the research of Stem Cell 3D Printing Technology and Organ Reconstruction for the past 20 years. We focus on the scientific problem of the regulation mechanism of engineering factors on the fate decision of stem cells, and revealing the influence of printing parameters, bioink viscoelasticity, geometrical structure and other engineering factors on the fate decision of stem cells. My group have systematically solved the cutting-edge problems of stem cells-bioprinting suitability, large-scale stem cells/tissue culture, and the synergistic control of 3D printing geometric-mechanical information on the key functions of organ function remodeling. We have achieved in vitro reconstruction and key functions of human tissue components such as fat, liver, tumor, etc., and explored the industrial transformation routes of cell 3D printing equipment and tissue and organ products. I have published more than 50 peer-reviewed and conference papers in Trends in Biotechnology, Nano Energy, Biomaterials, and Small and other journals, 10 of which were selected as cover stories, highlight articles, or highly cited papers (Top 1%). The total citations of the publications are more than 3300 times, with an H index of 25. We actively carry out technology transformation, licensed and applied for more than 30 Chinese and international invention patents, and the research results are technically transformed into three products to promote the practical application of 3D bioprinting equipment and tissue model products.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:

（#co-first author, *corresponding author） Wang X, Luo Y, Ma Y, Wang P, Yao R*. Converging bioprinting and organoids to better recapitulate the tumor microenvironment. Trends in Biotechnology. 2024, 42(5):648-663. Highlighted in Science and Technology Daily Yao R. Large-scale Bioprinting of tissues. Cell (Voice), 2024, 187, 4442. Liang S+, Luo Y+, Su Y, Zhang D, Wang S, Xu M, Yao R*. Distinct toxicity of microplastics/TBBPA co-exposure to bioprinted liver organoids derived from hiPSCs of healthy and patient donors. International Journal of Bioprinting. 2024. Chen R, Su Y, Chen D, Lu Y, Zhao J, Zhang Y, Yuan Q, Xu M*, Yao R*. Bioprinting with superelastic and fatigue-resistant bioinks for large-sized tissue delivery. International Journal of Bioprinting. 2024. Huo H, Liu F, Luo Y, Gu Q, Liu Y, Wang Z, Chen R, Ji L, Lu Y*, Yao R*, Cheng J*. Triboelectric nanogenerators for electro-assisted cell printing. Nano Energy. 2020; 67: 104150. Back Cover Report Chen R, Li L, Feng L, Luo Y, Xu M, Leong K*, Yao R*. Biomaterial-assisted scalable cell production for cell therapy. Biomaterials. 2020; 230: 119627. Feng L, Liang S, Zhou Y, Luo Y, Chen R, Huang Y, Chen Y, Xu M*, Yao R*. Three-Dimensional Printing of Hydrogel Scaffolds with Hierarchical Structure for Scalable Stem Cell Culture. ACS Biomaterials Science & Engineering. 2020; 6 (5): 2995-3004. Front Cover Report Ouyang L, Yao R*, Zhao Y, Sun W. Effect of bioink properties on printability and cell viability for 3D bioplotting of embryonic stem cells. Biofabrication. 2016; 8(3): 035020. ESI highly cited paper (top 1%) Zhao Y, Li Y, Mao S, Sun W, Yao R*. The influence of printing parameters on cell survival rate and printability in microextrusion-based 3D cell printing technology. Biofabrication. 2016; 7(4): 045002. IOP highly cited paper (top 1%) Yao R, Wang J, Li X, Da J, Qi H, Kee K, Du Y*. Hepatic Differentiation of Human Embryonic Stem Cells as Microscaled Multilayered Colonies Leading to Enhanced Homogeneity and Maturation. Small. 2014; 10(21): 4311-4323. Frontispiece Cover Report