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Name:
 Lili Cao
Subject:
 Immunology
Tel/Fax:
 +86-010-64887012  / 
E-mail:
 caolili@ioz.ac.cn
Address:
 The Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Lin Cui East Road, Chaoyang District, Beijing 100101, P.R.China
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Resume:

Eduction：

Sep 2007 - Jun 2012, Anhui Medical University, Bachelor of Preventive Medicine

Sep 2012 - Jun 2015, Peking University, Master's in Cell Biology

Sep 2015 - Jan 2019, Peking University, Ph.D. in Immunology

Research and Professional Experience:

Sep 2019 - Sep 2021, Peking University, Postdoctoral Researcher

Dec 2021 - Present, Institute of Zoology, Chinese Academy of Sciences, Associate Researcher

Research Interests:

Engaged in long-term research on innate immunity, focusing on exploring the molecular mechanisms of host-pathogen interactions and developing new pest control strategies based on these interactions.

Awards and Honors:

Professional Activities:

Research Grants:
  1. National Natural Science Foundation of China (32370507), 2024-2027;
  2. National Key Research and Development Program Youth Scientist Project (2022YFA0806900), 2023-2028;
  3. National Key Research and Development Program Project (2022YFD1400500), 2022-2025;
  4. National Natural Science Foundation of China Youth Science Fund Project (32000113), 2021-2023;
  5. 14th Special Funding of the China Postdoctoral Science Foundation (2021T140026), 2021-2022.

Selected Publications:
  1. Li J, Li JJ, Cao L, Chen Q, Ding D*, & Kang L*. An iron-binding protein of entomopathogenic fungus suppresses the proliferation of host symbiotic bacteria. Microbiome. 2024 Oct 15;12(1):202. doi: 10.1186/s40168-024-01928-4.
  2. Cao L# Luo Y#, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y*, You F*. SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs. PLOS Pathogens. 2022 Jun 3;18(6):e1010599.
  3. Cao L#, Liu S#, Li Y, Yang G, Luo Y, Li S, Du H, Lin R, Wang P, You F*. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host & Microbe. 2019 Sep 11;26(3):369-384.e8.
  4. Li S#, Kuang M#, Chen L, Li Y, Liu S, Du H, Cao L*, You F*. The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling. Cell Reports. 2021 Jan 19;34(3):108631.
  5. Cao L#, Yang G#, Gao S, Jing C, Montgomery R, Yin Y, Wang P, Fikrig E, You F. HIPK2 is necessary for type I interferon–mediated antiviral immunity. Science Signaling. 2019. Mar 19;12(573).
  6. Li Y#, Xu J#, Guo X#, Li Z#, Cao L, Liu S, Guo Y, Wang G, Luo Y, Zhang Z, Wei X, Zhao Y, Liu T, Wang X, Xia H, Kuang M, Guo Q, Li J, Chen L, Wang Y, Li Q, Wang F, Liu Q*, You F*. The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model. Genome Biology. 2023 Feb 1;24(1):20.
  7. Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F. TBK1-METTL3 axis facilitates antiviral immunity. Cell Reports. 2022 Feb 15;38(7):110373.
  8. Sun G, Qiu L, Yu L, An Y, Ding Y, Zhou L, Wu J, Yang X, Zhang Z, Tang X, Xia H, Cao L, You F, Zhao X, Du H. Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human. Journal of Clinical Immunology. 2022 May;42(4):798-810.
  9. Guo Q#, Zhao Y#, Li J#, Liu J#, Yang X#, Guo X, Kuang M, Xia H, Zhang Z, Cao L, Luo Y, Bao L, Wang X, Wei X, Deng W, Wang N, Chen L, Chen J, Zhu H, Gao R, Qin C#, Wang X#, You F#. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host & Microbe. 2021 Feb 10;29(2):222-235.e4.
  10. Li Y, Liu S, Cao L, Luo Y, Du H, Li S, Zhang Z, Guo X, Tian W, Wong C, You F. CBRPP: a new RNA-centric method to study RNA-protein interactions. RNA Biology. 2021 Feb 17;1-14.
  11. Wang Y#, Li S#, Zhao Y, Zhang B, Li Y, Liu S, Du H, Cao L, Ou M, Ye X, Li P, Gao X, Wang P, Jing C, Shao F, Yang G, You F. The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING. J Biol Chem. 2019 Nov 8;294(45):16494-16508.
  12. Cao L, Zhang L, Zhao X, Zhang Y. A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells. Plos One. 2016. 15;11(8).