Location: Home > Scientists
  Scientists
Name:
 Yan Wang
Subject:
 Genomics and epigenomics
Tel/Fax:
  / 
E-mail:
 yanwang @ioz.ac.cn
Address:
 Lincui East Road, Bldg #1, Institute of Genetics and Developmental Biology, Chaoyang District, Beijing 100101
More:
      
Resume:

Dr. Yan Wang is a Professor in the Institute of Zoology of the Chinese Academy of Sciences. In 2008, she was funded by the China Scholarship Council to visit and study at Michigan State University in the United States. In 2010, she got her Ph.D. from the Institute of Psychology, Chinese Academy of Sciences. Prof. Wang has systematically investigated the roles of serine/threonine protein kinase family member PAK2, complement-related protein CSMD3, and transcription factor NPAS3 in brain and neural development, as well as the mechanisms by which their dysfunctions contribute to neurodevelopmental disorders such as autism. Prof. Wang has elucidated the pathogenic mechanisms of PAK2 in neural tube defects across multiple model organisms. She has also established a mouse model of pure psychological stress during pregnancy, and studied the effects of prenatal psychological stress on the physiology and behavior of offspring and the corresponding regulatory mechanisms. Additionally, she has systematically summarized the roles of various epigenetic regulatory mechanisms in the transgenerational inheritance of acquired traits. She have published over 30 papers in journals such as Advanced Science, Cell Reports, Brain, Behavior, and Immunity, Biological Reviews, and Frontiers in Neuroendocrinology.

Research Interests:

Utilizing animal models to investigate the interplay between genetic and environmental factors in brain and neural development, as well as their influence on complex behaviors such as autism-like behaviors, anxiety, and depression.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Wang Y#, Zhang K#, Guo J#, Yang S #, Shi X, Pan J, Sun Z, Zou J, Li Y, Li Y, Fan T, Song W, Cheng F, Zeng C, Li J, Zhang T*, Sun Z*. Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects. Advanced Science. 2023,10, 2204018.
  2. Song W#, Li Q#, Wang T, Li Y, Fan T, Zhang J, Wang Q, Pan J, Dong Q, Sun Z*, Wang Y*. Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders. Brain, Behavior, and Immunity. 2022 (102): 237–250.
  3. Li Y #, Fan T#, Li X#, Liu L, Mao F, Li Y, Miao Z, Zeng C, Song W, Pan J, Zhou S, Sunday ME, Wang H, Wang Y*, Sun Z*. Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors. Cell Reports. 2022. August 30. (40): 111289.
  4. Zhang K#, Wang Y#*, Fan T, Zeng C and Sun Z*. The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorder. Protein Cell. 2022 Jan; 13 (1):6–25.
  5. Miao Z #, Li Y#, Mao F, Zhang J, Sun Z*, Wang Y*. Prenatal witness stress induces intergenerational anxiety-like behaviors and altered gene expression profiles in male mice. Neuropharmacology. 2021. 202.108857.
  6. Mei Y, Teng H, Li Z, Zeng C, Li Y, Song W, Zhang K, Sun Z*, Wang Y*. Restricted feeding resets endogenous circadian rhythm in female mice under constant darkness. Neuroscience Bulletin. 2021. 37, 1005–1009.
  7. Wang Y#, Wu H#, Sun Z*. The Biological Basis of Sexual Orientation: How Hormonal, Genetic or Environmental Factors Influence to Whom We are Sexually Attracted. Frontiers in Neuroendocrinology. 2019 (55). 100798.
  8. Miao Z, Zhang J, Li Y, Li X, Song W, Sun Z*, Wang Y*. Presence of the Pregnant Partner regulates microRNA-30a and BDNF levels and Protects Male Mice from Social Defeat-Induced Abnormal Behaviors. Neuropharmacology. 2019, 159: 107589.
  9. Wang Y#, Zeng C #, Li J #, Zhou Z, Ju X, Xia S, Li Y, Liu A, Teng H, Zhang K, Shi L, Bi C, Xie W, He X, Jia Z, Jiang Y, Cai T, Wu J, Xia K*, Sun Z*. PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior. Cell Reports. 2018, (24): 2029–2041. (F1000Prime Recommended).
  10. Wang Y, Liu H, Sun Z*. Lamarck rises from his grave: parental environment-induced epigenetic inheritance in model organisms and humans. Biological Reviews. 2017, 92 (4):2084–2111. (Top downloaded article 2017–2018 in Biological Reviews)

（#共同第一作者，*通讯作者）