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Name:
 Zhongsheng Sun
Subject:
 Genomics and epigenomics
Tel/Fax:
  / 
E-mail:
 sunzs @ioz.ac.cn
Address:
 Lincui East Road, Bldg #1, Institute of Genetics and Developmental Biology, Chaoyang District, Beijing 100101
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Resume:

Dr. Zhongsheng Sun, Professor. He got his bachelor's degree from Peking University in 1982 and his Ph.D. from Texas A&M University in 1992. Previously, he held the position of Assistant Professor at the Louisiana State University School of Medicine in New Orleans and the Weill Medical College of Cornell University. He has cloned the key mammalian circadian clock genes mPer1 and mPer2, thereby elucidating the molecular basis of the mammalian circadian clock. It was honored as one of the top ten scientific breakthroughs by Science magazine in 1997. In 2017, he received the Third Prize for Scientific and Technological Achievements from the Beijing Branch of the Chinese Academy of Sciences. In 2018, he received the Scholar Award of the WuXi AppTec Life Science Research Award.

His research primarily focuses on understanding life phenomena and human diseases through the development of new technologies and analytical tools in genomics, transcriptomics, and epigenomics. He has developed several powerful analytical tools and databases that integrate clinical data with genetic information, providing methodological support for the identification of candidate genes for complex diseases. He has systematically studied the relationships between genotype and clinical phenotype in neuropsychiatric disorders such as autism. He has published over 130 papers in journals such as Cell, Molecular Psychiatry, American Journal of Human Genetics, Blood, Advanced Science, Nucleic Acids Research, and Cell Reports.

Research Interests:

He is dedicated to developing new technologies and analytical tools in genomics, transcriptomics, and epigenomics, and applying these tools to investigate the genetic and epigenetic regulatory mechanisms underlying cancer, advanced mood disorders, and complex behaviors.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Wang Y, Zhang K, Guo J, Yang S, Shi X, Pan J, Sun Z, Zou J, Li Y, Li Y, Fan T, Wei S, Cheng F, Zeng C, Li J, Zhang T*, Sun Z*. Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects. Advanced Science. 2023, 10, 2204018.
  2. Li Y, FanT, Li X, Liu L, Mao F, LiY, Miao Z, Zeng C, Song W, Pan J, Zhou S, Sunday ME, Wang H, Wang Y,* and Sun Z*. Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors. Cell Reports. 2022, 40(9):111289.
  3. Wang T, Zhao T , Liu L, Teng H, Fan T, Li Y, Wang Y, Li J*, Xia K*, and Sun Z*. Integrative analysis prioritised oxytocin-related biomarkers associated with the aetiology of autism spectrum disorder. eBioMedicine. 2022, 81:104091.
  4. Liang J, Zhang K, Yang J, Li X, Li Q, Wang Y, Cai W, Teng H* and Sun Z*. A new approach to decode DNA methylome and genomic variants simultaneously from double strand bisulfite sequencing. Briefings in Bioinformatics. 2021; 5;22(6):bbab201.
  5. Teng H, Xue M, Liang J, Wang X, Wang L, Wei W, Li C, Zhang Z, Li Q, Ran X, Shi X, Cai W, Wang W, Gao H, Sun Z*. Inter- and intratumor DNA methylation heterogeneity associated with lymph node metastasis and prognosis of esophageal squamous cell carcinoma. Theranostics. 2020; 10(7):3035-3048.
  6. Teng H, Wei W, Li Q, Xue M, Shi X, Li X, Mao F*, Sun Z*. Prevalence and architecture of posttranscriptionally impaired synonymous mutations in 8320 genomes across 22 cancer types. Nucleic Acids Research.2020; 48(3):1192-1205.
  7. Li J, Hu S, Zhang K, Shi L, Zhang Y, Zhao T, Wang L, He X, Xia K, Liu C, Sun Z*. A comparative study of the genetic components of three subcategories of autism spectrum disorder. Mol Psychiatry. 2019;24(11):1720-1731.
  8. Wang Y, Zeng C, Li J, Zhou Z, Ju X, Xia S, Li Y, Liu A, Teng H, Zhang K, Shi L, Bi C, Xie W, He X, Jia Z, Jiang Y, Cai T, Wu J, Xia K*, Sun Z*. PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior. Cell Rep. 2018;24(8):2029-2041.
  9. Liu Y, Liang Y, Cicek AE, Li Z, Li J, Muhle RA, Krenzer M, Mei Y, Wang Y, Knoblauch N, Morrison J, Zhao S, Jiang Y, Geller E, Ionita-Laza I, Wu J Xia K, Noonan JP, Sun ZS*, He X*. A Statistical Framework for Mapping Risk Genes from De Novo Mutations in Whole-Genome-Sequencing Studies. American Journal of Human Genetics, 2018, 102(6):1031-1047.
  10. Liang J#, Feng D#, Cai W#, Teng H, Mao F, Jiang Y, Hu S, Li X, Zhang Y, Liu B*, Sun Z*. Genetic landscape of papillary thyroid carcinoma in the Chinese population. The Journal of Pathology, 2018, 244(2):215-226.