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Name:
 SUN Wen
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-82610049  / 
E-mail:
 sunwen@ioz.ac.cn
Address:
 State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Yard A 3, Datun Road, Chaoyang District, Beijing 100101, P.R.China.
More:
 Group of Genome Engineering Technology      
Resume:

Dr Sun received his Ph.D. in Biomedical Sciences from the University of Macau in September 2017. In October 2017, he joined the Group of Genome Engineering Technology as an assistant investigator. From November 2022 to October 2023, he conducted research as a visiting scholar at the University of Strasbourg in France, funded by China Scholarship Council (CSC). He was promoted to associate investigator in 2025.

Research Interests:

Development and applications of novel gene-editing tools

Awards and Honors:

Professional Activities:

Research Grants:
  • National Natural Science Foundation of China Youth Research Project (32001062), 2021-2023, PI
  • National Key Research and Development Program (2018YFE0201102), 2019-2023, subproject PI
  • National Key Research and Development Program (2024YFC3406703), 2024-2027, subproject member
  • Beijing Institute for Stem Cell and Regenerative Medicine, Incubation Fund (2023FH106), 2023-2025, PI

Selected Publications:

(#: co-first authors; *: co-corresponding authors)

  1. Hu XX#, Zhang XC#, Sun W#*, Liu CH#, Deng PJ, Cao YW, Zhang CZ, Xu N, Zhang TT, Zhang Y, Liu JJ, Wang HY*. Systematic discovery of DNA-binding tandem repeat proteins. Nucleic Acids Research, 2024, 52, 10464–10489.
  2. Zhang XC#, Hu XX#, Zhang TT, Yang L, Liu CH, Xu N, Wang HY*, Sun W*. PLM_Sol: predicting protein solubility by benchmarking multiple protein language models with the updated Escherichia coli protein solubility dataset. Briefings in Bioinformatics, 2024, 25(5), bbae404.
  3. Shang YD#, Wang NN#, Wang HY, An CR*, Sun W*. Modeling X chromosome inactivation using t5iLA naive human pluripotent stem cells. BMC Biology, 2024, 22, 210.
  4. Wang Y#, Yang N#, Sun W#, Zhao C, Hu XX, Lu S, Cao SW, Wang NN, Hai T, Feng GH*, An CR*, Wang HY* Characterization of X chromosome status of human extended pluripotent stem cells. Cell Proliferation, 2023, 56: e13468.
  5. Song YZ#, Chen Min#, Zhang YF, Li JY, Liu BW, Chen M, Qiao MM, Wang N, Cao YW, Lu S, Chen J, Sun W*, Gao F*, Wang HY*. Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis. Life Science Alliance, 2022, 6(2), e202201617.
  6. Sun W, Wang HY*. Recent advances of genome editing and related technologies in China. Gene Therapy, 2020, 27, 312–320. (Invited review)
  7. Cao YW#, Sun W#, Wang JF, Sheng G, Xiang GH, Zhang TT, Shi WY, Li C, Wang YL, Zhao FQ*, Wang HY*. Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 °C. Cell Discovery, 2019, 5, 38.