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Name:
 Xiaonan Fu
Subject:
 Biotechniology/Genomics/ Immunomic
Tel/Fax:
 010-64806392  / 
E-mail:
 xnfu@ioz.ac.cn
Address:
 Key Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R. China
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Resume:

2003-2007 B.S. Life Science, East China Normal University, Shanghai, China

2007-2010 M.S. Genomics, East China Normal University, Shanghai, China

2012-2018 Ph.D. Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, Virginia, USA

2018-2024 Postdoctoral Fellow, University of Washington, Seattle, Washington, USA

2024-2025 Instructor, University of Washington, Seattle, Washington, USA

2025/-present, Professor, Principal Investigator, Institute of Zoology, Chinese Academy of Sciences

Research Interests:

My laboratory develops micron-scale biochip-based spatial omics technologies to resolve subcellular heterogeneity, regulatory dynamics, and cell-cell interactions in complex biological systems. By integrating high-resolution spatial mapping of proteins, RNA, and DNA modifications, we investigate host-pathogen interactions in reservoir species such as bats and rodents, revealing pathogen niches and localized immune responses. Through high-throughput antibody epitope profiling and BCR/TCR analysis, we aim to decode adaptive immunity and assess cross-species transmission risks.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. AT Luskin *, L Li *, X Fu, K Barcomb, T Blackburn, EM Li, A Rana, R Simon, A Murry, SA Golden, GD Stuber, CP Ford, L Gu, and MR Bruchas. Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours. Nature, 2025 May 7.  doi: 10.1038/s41586-025-08952-w.
  2. Y Ye* , J Li* , W Li* , X Fu* , J Zhang , S Yang , W Du. Transcriptional Control of Male-specific Pathway in Temperature-dependent Sex Determination. Science Bulletin. (2025, accepted)
  3. AU Gurkar, AA Gerencser, AL Mora, AC Nelson, AR Zhang, AB Lagnado, ...,X Fu, ZB, Joseph, Z Ji, JF Passos. Spatial mapping of cellular senescence: emerging challenges and opportunities. Nature aging 2023 Jul 3 (7), 776-790
  4. X Fu*, L Sun*, R Dong*, JY Chen, R Silakit, LF Condon, Y Lin, S Lin, RD Palmiter, L Gu. Polony gels enable amplifiable DNA stamping and spatial transcriptomics of chronic pain. Cell, 04 Nov 2022, :S0092-8674(22)01367-8
  5. P Liu*, X Fu*, J Zhu. Juvenile hormone-regulated alternative splicing of the taiman gene primes the ecdysteroid response in adult mosquitoes. Proceedings of the National Academy of Sciences 115 (33), E7738-E7747
  6. X Fu *, P Liu*, J Zhu. Dynamic miRNA-mRNA interactions coordinate gene expression in adult Anopheles gambiae. PLoS Genet. 2020 Apr; 16(4): e1008765.
  7. X Xia*, X Fu*, B Wu, J Zhu, Z Zhao. Regulation of circadian rhythm and sleep by miR‐375‐timeless interaction in Drosophila. FASEB J. 2020 Dec; 34(12): 16536-16551.
  8. S Dong, X Fu, Y Dong, ML Simões, J Zhu, G Dimopoulos. Broad spectrum immunomodulatory effects of Anopheles gambiae microRNAs and their use for transgenic suppression of Plasmodium. PLOS Pathogens 16(4): e1008453.