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Name:
 Xiaoyan Wang
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-64807196  / 
E-mail:
 xyan.wang@ioz.ac.cn
Address:
 Institute of Zoology, CAS, Yard A 3, Datun Road, Chaoyang District, Beijing 100101, China
More:
 Stem Cell and Gonadal Development      
Resume:

Xiaoyan Wang, M.D., Ph.D., Associate Professor of Institute of Zoology, Chinese Academy of Sciences. Member of the Stem Cell and Gonadal Development Group.

Education Experience

  • 2009.09-2016.06, Cheeloo College of Medicine, Shandong University, Clinical Medicine, Degree: M.D./M.Sc., Supervisor：Prof. Zi-Jiang Chen
  • 2016.09-2020.06, Cheeloo College of Medicine, Shandong University, Obstetrics and Gynecology, Degree: Ph.D. in Medicine, Supervisor：Prof. Zi-Jiang Chen

Professional Experience

  • 2021.12-2025.02, Institute of Zoology, Chinese Academy of Sciences, Postdoctoral Fellow, Advisor: Prof. Jingtao Guo
  • 2025.02-Present, Institute of Zoology, Chinese Academy of Sciences, Associate Professor

Research Interests:
  • Integrating cross-species multi-omics data with artificial intelligence approaches to elucidate evolutionary conservation and species-specific mechanisms of gonadal development and gametogenesis.
  • Developing innovative experimental–computational strategies to uncover disease mechanisms and advance clinical translation of reproductive disorders, aiming to identify key pathogenic genes and novel diagnostic targets.

Awards and Honors:

Professional Activities:

Research Grants:
  • National Natural Science Foundation of China, General Program, 2026.01-2029.12
  • Strategic Priority Research Program of the Chinese Academy of Sciences (Class B), 2025.04-2028.03
  • National Natural Science Foundation of China, Youth Scientist Program, 2024.01-2026.12
  • Initiative Scientific Research Program supported by the Institute of Zoology, Chinese Academy of Sciences, 2024.01-2026.12
  • Special Research Assistant Program, Chinese Academy of Sciences, 2022.11-2024.10
  • China Postdoctoral Science Foundation, General Program, 2022.07-2024.06

Selected Publications:

（# Co-first author, * Co-corresponding author）

  1. Yang Yuan#, Xiaoyan Wang#, Xiaodi Yan#, Nannan He#, Xiaojian Lu#, Jingyu Yang#, Xinwei Xie#, Huiyao Yuan, Naixin Chen, Yinbo Liu, Hongan Ren, Runzhao Zhang, Lina Cui, Pengcheng Ren, Sirui Lin, Shuhan Cheng, Xiaolong Yang, Yifei Guo, Rong Li, Tianyi Yan, Jingtao Guo, Zhenyu Xiao, Yulei Wei, Leqian Yu. 3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation. Cell Stem Cell. 2025 Jun 5;32(6):1006-1024.e5.
  2. Qiaoling Jiang, Lina Cui, Xichen Nie, Hui Cai, Wenxiu Zhang, Xiaojian Lu, Yifei Guo, James M Hotaling, Bradley R Cairns, Xiaoyan Wang*, Jingtao Guo*. A Single-Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging. Aging Cell. 2025 Mar 6:e70032.
  3. Lina Cui#, Sirui Lin#, Xiaolong Yang#, Xinwei Xie#, Xiaoyan Wang#, Nannan He#, Jingyu Yang, Xin Zhang, Xiaojian Lu, Xiaodi Yan, Yifei Guo, Bailing Zhang, Ran Li, Hefan Miao, Mei Ji, Runzhao Zhang, Leqian Yu*, Zhenyu Xiao*, Yulei Wei*, Jingtao Guo*. Spatial Transcriptomic Characterization of a Carnegie Stage 7 Human Embryo. Nat Cell Biol. 2025 Feb;27(2):360-369.
  4. Xiaoyan Wang#, Liping Cheng#, Xiaojian Lu#, He Jin#, Lina Cui, Yifei Guo, Jingtao Guo*, Eugene Yujun Xu*. Cross-Species Comparative Single-Cell Transcriptomics Highlights the Molecular Evolution and Genetic Basis of Male Infertility. Cell Rep. 2025 Jan 28;44(1):115118.
  5. Xiaoyan Wang#, Qiang Liu#, Ziyan Zhuang#, Jianxing Cheng, Wenxiu Zhang, Qiaoling Jiang, Yifei Guo, Ran Li, Xiaojian Lu, Lina Cui, Jiaming Weng, Yanlin Tang, Jingwei Yue, Songzhan Gao, Kai Hong, Jie Qiao, Hui Jiang*, Jingtao Guo*, Zhe Zhang*. Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling. Cell Rep Med. 2024 Sep 17;5(9):101709.
  6. Xiaoyan Wang#, Yang Wang#, Yu Wang#, Yifei Guo#, Ruojun Zong, Shuaitao Hu, Jingwei Yue, Jing Yao, Chunsheng Han*, Jingtao Guo*, Jianguo Zhao*. Single-cell transcriptomic and cross-species comparison analyses reveal distinct molecular changes of porcine testes during puberty. Commun Biol. 2024 Nov 9;7(1):1478.
  7. Zhenyu Xiao#, Lina Cui#, Yang Yuan#, Nannan He#, Xinwei Xie, Sirui Lin, Xiaolong Yang, Xin Zhang, Peifu Shi, Zhifeng Wei, Yang Li, Hongmei Wang, Xiaoyan Wang*, Yulei Wei*, Jingtao Guo*, Leqian Yu*. 3D reconstruction of a gastrulating human embryo. Cell. 2024 May 23;187(11):2855-2874.e19.
  8. Xiaoyan Wang, Zi-Jiang Chen. A decade of discovery: the stunning progress of premature ovarian insufficiency research in China. Biol Reprod. 2022 Jul 25;107(1):27-39. Review.
  9. Xiaoyan Wang, Bradley R Cairns, Jingtao Guo. When spermatogenesis meets human aging and elevated body mass. Life Med. 2022 Jul 9;1(3):267-269. Research Highlight.
  10. Xiaoyan Wang, Xinyue Zhang, Yujie Dang, Duan Li, Gang Lu, Wai-Yee Chan, Peter C K Leung, Shidou Zhao, Yingying Qin, Zi-Jiang Chen. Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1. Nucleic Acids Res. 2020 May 7;48(8):4480-4491.
  11. Xiaoyan Wang, Xiruo Zhang, Shan Liu, Guangyu Li, Linlin Cui, Yingying Qin, Zi-Jiang Chen, Novel mutations in the TP63 gene are potentially associated with Müllerian duct anomalies. Hum Reprod. 2016 Dec;31(12):2865-2871.