Research Progress

• 
  IOZ scientists discovered the mechanism of fate determination of embryonic T lymphoid-primed progenitor

  In vertebrates, all blood cells are generated through hematopoiesis. During the definitive hematopoiesis, hematopoietic stem cells (HSCs) are generated and give rise to various blood lineages including lymphoid cells, myeloid cells and erythroid cells.

  Aug 21, 2015
• 
  COOL PANDAS

  The giant panda has exceptionally low daily energy expenditure allowing it to survive on its bamboo diet. The low expenditure is linked to low levels of physical activity and low levels of thyroid hormones probably caused by a genetic mutation in the thyroid hormone production pathway.

  Jul 13, 2015
• 
  Scientists discovered Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression

  During vertebrate embryogenesis, the neuroectoderm is induced from dorsal ectoderm and then partitioned into anterior and posterior neuroectodermal domains by posteriorizing signals, such as Wnt and fibroblast growth factor. However, little is known about epigenetic regulation of posteriorizing gene expression.

  Jul 10, 2015
• 
  Big Roles of MicroRNAs: CAS Scientists Reveal Functions of MicroRNAs in Regulating m6A Formation

  Scientists have identified novel functions of microRNAs in regulating the formation of m6A RNA modification, and the positive role of m6A in promoting cell reprogramming. The findings reveal newmechanisms in regulating cell function and cell fate determination.

  Feb 13, 2015
• 
  Water Channel-dependent excessive uterinefluid impairs embryo implantation

  In mammalian species, embryo implantation is the threshold for pregnancy establishment, the abnormality of which accounts for ~75% of human pregnancy loss. Abnormal preimplantation hormonal environment is a common cause for defective embryo implantation, usually attributed to the changed endometrium receptivity. Here, a research group lead by Prof. EnkuiDuan at institute of Zoology, Chinese Academy of Sciences, showed that the abnormal preimplantation hormonal environment also disrupt intrauterine fluid homeostasis that constitute a major cause for impairedembryo implantation.

  Nov 18, 2014
• 
  Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling

  Jul 18, 2014
• 
  Chinese Wall of Ants - New wasp species protects its progeny with dead ants

  Jul 04, 2014
• 
  TLR ligands and IFN-γ exhibit antagonistic effects on protease HTRA1 expression in rheumatoid arthritis

  Jul 03, 2014
• 
  Embryo-uterine orientation at implantation requires uterine RBPJ signaling

  Rodent blastocysts show remarkably consistent embryonic orientation with respect to the uterine structure, an orientation established at initial implantation which blueprints the direction of future embryo-uterine axis. However, despite this interesting phenomenon having been discovered more than 100 years (since 1894), there have been few molecular mechanisms found responsible for this trait.

  Jul 02, 2014
• 
  A Protocol for Species Delineation of Public DNA Databases was developed by Chao-Dong ZHU’s lab and published on-line in Systematic Biology

  Jun 16, 2014