Research Progress

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  Nature: m6A modulates hematopoietic stem and progenitor cell specification

  Hematopoietic stem cells (HSCs) are the only cells which have the capability to self-renew and differentiate into all blood lineages. The limit of the donors to provide sufficient HSCs in the clinic makes it urgent to produce HSCs ex vivo or in vitro in regenerative medicine

  Sep 07, 2017
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  Establishment of haploid somatic cell-based genetic screening system

  Haploid cells have only one set of chromosomes, and therefore are a valuable tool in genetic screening and transgenic animal production. In previous studies, mammalian haploid embryonic stem cells have been established. However, since haploid embryonic stem cells undergo spontaneous diploidization during culture and differentiation, there are challenges in establishing haploid somatic cells and somatic cell-based genetic screening system.

  Aug 30, 2017
• Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation

  Aug 24, 2017
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  A new mechanism of hematopoietic stem cell expansion identified

  The allusion of mencius’ mother moving three time tells us that a proper environment is particularly important for children’s growing up. In the case of hematopoietic stem and progenitor cells (HSPCs), the microenvironment is dynamic in vivo during HSPC development.

  Aug 11, 2017
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  Scientists unlock planthoppers'potential to control future crop disease outbreaks

  Researchers from the Chinese Academy of Sciences’ Institute of Zoology have discovered how a severe rice virus reproduces inside the small brown planthopper, a major carrier of the virus, and have published this work in eLIFE recently.

  Aug 09, 2017
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  Phosphatase Wip1 may be an important molecular target to treat allergic airway inflammation

  Allergic asthma is one of the most common chronic diseases, resulting in a substantial burden of diseases. Although rates of deaths due to asthma worldwide have shrunk greatly over the past 25 years, no available therapeutic regimens can yet cure this complex disease.

  Jul 31, 2017
• The biology of uterine fluid: How it informs the fetus of mom's world

  Jun 23, 2017
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  An Epigenetic Signaling Axis Regulates Proliferation and Self-renewal of Neural Stem/Progenitor Cells

  Polycomb group (PcG) proteins comprise the Polycomb complexes PRC1 and PRC2 that regulate gene expression levels through histone modification. Although PRC1 and PRC2 are emerging to play important roles in cancer stem cells, their roles in neural stem/progenitor cells (NSPCs) are largely unknown.

  Jun 08, 2017
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  Discovery of speciation timing and introgression between the brown rats and its sibling species

  Brown rats (Rattus norvegicus) are successful global colonizers, and they are notorious for damaging agricultural crops and for transmission of infectious diseases to mankind due to its commensal relationship with humans.

  May 22, 2017
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  Discovery of a “double-brake” like neurochemical mechanism underlying locust swarming

  Swarming widely occurs in the animal kingdom. Colonial individuals usually change their behaviors to adapt environmental variation, thus displaying distinguish behavioral plasticity.

  May 11, 2017