Research Progress

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  Pig mutants aid to decipher the novel mechanism underlying the thyroid hormone deficiency associated anemia and immunodeficiency

  Congenital hypothyroidism (CH) is caused by thyroid hormone (TH) deficiencies. CH is one of the most prevalent endocrine diseases, occurring in 1 of 1400 to 2800 newborns. Based on anemia often being the first sign of hypothyroidism, accounting for 20% to 60% in hypothyroid patients, the current clinical guidelines recommend evaluating thyroid function in the workup of anemia.

  Oct 23, 2017
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  Subcortical Maternal Complex: a Functional Module in the Mammalian Oocyte-to-zygote Transition

  Human reproductive disorders affect people all over the world, bringing both personal sufferings and heavy social burdens. The advanced assisted reproductive technologies (ART) have helped the couples successfully conceive their babies; however, reproductive wastage frequently occurs even in early stage of embryogenesis with unexplained reasons.

  Oct 10, 2017
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  Epigenetic regulation of left-right asymmetry by DNA methylation

  DNA methylation is one of the major epigenetic modifications in vertebrates, which involves adding a methyl group to the 5th carbon of cytosine to form 5-methylcytosine (5mC), which is established and maintained by DNA methyltransferases (DNMT).

  Sep 12, 2017
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  Nature: m6A modulates hematopoietic stem and progenitor cell specification

  Hematopoietic stem cells (HSCs) are the only cells which have the capability to self-renew and differentiate into all blood lineages. The limit of the donors to provide sufficient HSCs in the clinic makes it urgent to produce HSCs ex vivo or in vitro in regenerative medicine

  Sep 07, 2017
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  Establishment of haploid somatic cell-based genetic screening system

  Haploid cells have only one set of chromosomes, and therefore are a valuable tool in genetic screening and transgenic animal production. In previous studies, mammalian haploid embryonic stem cells have been established. However, since haploid embryonic stem cells undergo spontaneous diploidization during culture and differentiation, there are challenges in establishing haploid somatic cells and somatic cell-based genetic screening system.

  Aug 30, 2017
• Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation

  Aug 24, 2017
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  A new mechanism of hematopoietic stem cell expansion identified

  The allusion of mencius’ mother moving three time tells us that a proper environment is particularly important for children’s growing up. In the case of hematopoietic stem and progenitor cells (HSPCs), the microenvironment is dynamic in vivo during HSPC development.

  Aug 11, 2017
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  Scientists unlock planthoppers'potential to control future crop disease outbreaks

  Researchers from the Chinese Academy of Sciences’ Institute of Zoology have discovered how a severe rice virus reproduces inside the small brown planthopper, a major carrier of the virus, and have published this work in eLIFE recently.

  Aug 09, 2017
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  Phosphatase Wip1 may be an important molecular target to treat allergic airway inflammation

  Allergic asthma is one of the most common chronic diseases, resulting in a substantial burden of diseases. Although rates of deaths due to asthma worldwide have shrunk greatly over the past 25 years, no available therapeutic regimens can yet cure this complex disease.

  Jul 31, 2017
• The biology of uterine fluid: How it informs the fetus of mom's world

  Jun 23, 2017